View in EDS HTML Full Text PDF Full Text

Epilepsy with auditory features: Long‐term outcome and predictors of terminal remission.

Saved in:
Bibliographic Details
Title: Epilepsy with auditory features: Long‐term outcome and predictors of terminal remission.
Authors: Bisulli, Francesca, Menghi, Veronica, Vignatelli, Luca, Licchetta, Laura, Zenesini, Corrado, Stipa, Carlotta, Morigi, Francesca, Gizzi, Matteo, Avoni, Patrizia, Provini, Federica, Mostacci, Barbara, d'Orsi, Giuseppe, Pippucci, Tommaso, Muccioli, Lorenzo, Tinuper, Paolo
Source: Epilepsia (Series 4). Apr2018, Vol. 59 Issue 4, p834-843. 10p.
Subjects: Diagnosis of epilepsy, Epilepsy, Electroencephalography, Regression analysis, Multivariate analysis, Prognosis
Abstract: Summary: Objective: To assess the long‐term outcome of epilepsy with auditory features (EAF) and to identify the clinical predictors for prognosis. Methods: The study involved consecutive EAF patients with a follow‐up of ≥5 years. Terminal remission (TR) was defined as a period of ≥5 consecutive years of seizure freedom at the last follow‐up. We used Kaplan‐Meier estimate to calculate the cumulative time‐dependent probability of conversion to TR. Log‐rank test and multivariate Cox regression analyses were performed to study the association between time to TR and prognostic determinants. Results: We included 123 EAF patients (male/female = 58/65) with a median follow‐up of 11 years (1626.9 person‐years). Most were sporadic cases (68.3%), whereas 31.7% reported a family history of epilepsy. At last assessment, 42 patients had achieved TR (34.1%). Of the remaining 81 cases with no TR (65.9%), 37% had been in remission for 1‐4 years and 62.9% still had seizures within the past year. The cumulative rates of TR were 26.6%, 35.7%, and 51.6% at 10, 20, and 30 years from inclusion. On multivariate analysis, age at onset > 10 years (hazard ratio [HR] = 3.2, P = .028), auditory aura characterized by distortions only versus simple/complex hallucinations (HR = 2.9, P = .041), and unremarkable scalp electroencephalogram (EEG) versus EEG with focal epileptiform activity (HR = 3.5, P = .041) were associated with TR. Significance: Our data show a wide prognostic spectrum of EAF, ranging from mild forms with spontaneous remission, to severely refractory epilepsy addressed to surgery. The outcome, less favorable than expected from previous studies, appears to be primarily a function of 3 prognostic negative risk factors: age at onset < 10 years, auditory aura characterized by complex auditory hallucinations, and focal epileptiform abnormalities on scalp EEG. These predictors, easy to collect even at the first visit, may inform both clinicians and patients about the long‐term prognosis and aid patient management. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 128816764
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Epilepsy with auditory features: Long‐term outcome and predictors of terminal remission.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bisulli%2C+Francesca%22&quot;&gt;Bisulli, Francesca&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Menghi%2C+Veronica%22&quot;&gt;Menghi, Veronica&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vignatelli%2C+Luca%22&quot;&gt;Vignatelli, Luca&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Licchetta%2C+Laura%22&quot;&gt;Licchetta, Laura&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zenesini%2C+Corrado%22&quot;&gt;Zenesini, Corrado&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stipa%2C+Carlotta%22&quot;&gt;Stipa, Carlotta&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Morigi%2C+Francesca%22&quot;&gt;Morigi, Francesca&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gizzi%2C+Matteo%22&quot;&gt;Gizzi, Matteo&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Avoni%2C+Patrizia%22&quot;&gt;Avoni, Patrizia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Provini%2C+Federica%22&quot;&gt;Provini, Federica&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mostacci%2C+Barbara%22&quot;&gt;Mostacci, Barbara&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22d&#39;Orsi%2C+Giuseppe%22&quot;&gt;d&#39;Orsi, Giuseppe&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pippucci%2C+Tommaso%22&quot;&gt;Pippucci, Tommaso&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Muccioli%2C+Lorenzo%22&quot;&gt;Muccioli, Lorenzo&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tinuper%2C+Paolo%22&quot;&gt;Tinuper, Paolo&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Epilepsia+%28Series+4%29%22&quot;&gt;Epilepsia (Series 4)&lt;/searchLink&gt;. Apr2018, Vol. 59 Issue 4, p834-843. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diagnosis+of+epilepsy%22&quot;&gt;Diagnosis of epilepsy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Epilepsy%22&quot;&gt;Epilepsy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Electroencephalography%22&quot;&gt;Electroencephalography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Regression+analysis%22&quot;&gt;Regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Multivariate+analysis%22&quot;&gt;Multivariate analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Prognosis%22&quot;&gt;Prognosis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Summary: Objective: To assess the long‐term outcome of epilepsy with auditory features (EAF) and to identify the clinical predictors for prognosis. Methods: The study involved consecutive EAF patients with a follow‐up of ≥5 years. Terminal remission (TR) was defined as a period of ≥5 consecutive years of seizure freedom at the last follow‐up. We used Kaplan‐Meier estimate to calculate the cumulative time‐dependent probability of conversion to TR. Log‐rank test and multivariate Cox regression analyses were performed to study the association between time to TR and prognostic determinants. Results: We included 123 EAF patients (male/female = 58/65) with a median follow‐up of 11 years (1626.9 person‐years). Most were sporadic cases (68.3%), whereas 31.7% reported a family history of epilepsy. At last assessment, 42 patients had achieved TR (34.1%). Of the remaining 81 cases with no TR (65.9%), 37% had been in remission for 1‐4 years and 62.9% still had seizures within the past year. The cumulative rates of TR were 26.6%, 35.7%, and 51.6% at 10, 20, and 30 years from inclusion. On multivariate analysis, age at onset &gt; 10 years (hazard ratio [HR] = 3.2, &lt;italic&gt;P&lt;/italic&gt; = .028), auditory aura characterized by distortions only versus simple/complex hallucinations (HR = 2.9, &lt;italic&gt;P&lt;/italic&gt; = .041), and unremarkable scalp electroencephalogram (EEG) versus EEG with focal epileptiform activity (HR = 3.5, &lt;italic&gt;P&lt;/italic&gt; = .041) were associated with TR. Significance: Our data show a wide prognostic spectrum of EAF, ranging from mild forms with spontaneous remission, to severely refractory epilepsy addressed to surgery. The outcome, less favorable than expected from previous studies, appears to be primarily a function of 3 prognostic negative risk factors: age at onset &lt; 10 years, auditory aura characterized by complex auditory hallucinations, and focal epileptiform abnormalities on scalp EEG. These predictors, easy to collect even at the first visit, may inform both clinicians and patients about the long‐term prognosis and aid patient management. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=128816764
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/epi.14033
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 834
    Subjects:
      – SubjectFull: Diagnosis of epilepsy
        Type: general
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Electroencephalography
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Prognosis
        Type: general
    Titles:
      – TitleFull: Epilepsy with auditory features: Long‐term outcome and predictors of terminal remission.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bisulli, Francesca
      – PersonEntity:
          Name:
            NameFull: Menghi, Veronica
      – PersonEntity:
          Name:
            NameFull: Vignatelli, Luca
      – PersonEntity:
          Name:
            NameFull: Licchetta, Laura
      – PersonEntity:
          Name:
            NameFull: Zenesini, Corrado
      – PersonEntity:
          Name:
            NameFull: Stipa, Carlotta
      – PersonEntity:
          Name:
            NameFull: Morigi, Francesca
      – PersonEntity:
          Name:
            NameFull: Gizzi, Matteo
      – PersonEntity:
          Name:
            NameFull: Avoni, Patrizia
      – PersonEntity:
          Name:
            NameFull: Provini, Federica
      – PersonEntity:
          Name:
            NameFull: Mostacci, Barbara
      – PersonEntity:
          Name:
            NameFull: d'Orsi, Giuseppe
      – PersonEntity:
          Name:
            NameFull: Pippucci, Tommaso
      – PersonEntity:
          Name:
            NameFull: Muccioli, Lorenzo
      – PersonEntity:
          Name:
            NameFull: Tinuper, Paolo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 00139580
          Numbering:
            – Type: volume
              Value: 59
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Epilepsia (Series 4)
              Type: main
ResultId 1