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Risk of epilepsy after a single seizure in multiple sclerosis.

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Title: Risk of epilepsy after a single seizure in multiple sclerosis.
Authors: Mahamud, Z., Burman, J., Zelano, J.
Source: European Journal of Neurology. Jun2018, Vol. 25 Issue 6, p854-860. 7p. 1 Diagram, 2 Charts, 2 Graphs.
Subjects: Epilepsy risk factors, Multiple sclerosis, Status epilepticus diagnosis, Etiology of diseases, Disease progression, Patients
Abstract: Background and purpose: The 2014 International League Against Epilepsy clinical definition of epilepsy allows diagnosis after a single unprovoked seizure if the 10‐year recurrence risk exceeds 60%. Multiple sclerosis (MS) carries an increased risk of epilepsy, but the risk after a first seizure is unknown. We aimed to investigate the risk of epilepsy in patients with MS who had suffered a first seizure. Methods: We cross‐referenced data from the Swedish MS register with the national patient register for 15 810 patients with MS and 43 635 controls and included 289 patients with MS and 222 controls with a first diagnosis of seizure or status epilepticus (SE) without prior epilepsy or presumed symptomatic aetiology. Kaplan–Meier curves were used to estimate the risk of epilepsy. Results: The 10‐year risk of epilepsy was 51.4% [95% confidence interval (CI), 44.0–58.9] for patients with MS and 41.3% (95% CI, 33.5–49.1) for controls. The risk was 46.1% (95% CI, 35.3–56.9) for patients with relapsing‐remitting MS and 60.7% (95% CI, 46.6–74.8) for patients with secondary progressive MS. For patients with MS with SE, the 10‐year risk of epilepsy was 85.9% (95% CI, 67.9–100). Conclusions: Our data indicate that patients with relapsing‐remitting MS have a similar risk as controls of developing epilepsy after a single seizure. Patients with secondary progressive MS could run a greater risk of subsequent epilepsy, but our data do not indicate a risk that, with certainty, exceeds the threshold specified by the International League Against Epilepsy. Patients with SE have a high risk of epilepsy, possibly motivating diagnosis and treatment. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Risk of epilepsy after a single seizure in multiple sclerosis.
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  Data: <searchLink fieldCode="AR" term="%22Mahamud%2C+Z%2E%22">Mahamud, Z.</searchLink><br /><searchLink fieldCode="AR" term="%22Burman%2C+J%2E%22">Burman, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Zelano%2C+J%2E%22">Zelano, J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jun2018, Vol. 25 Issue 6, p854-860. 7p. 1 Diagram, 2 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Epilepsy+risk+factors%22">Epilepsy risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Status+epilepticus+diagnosis%22">Status epilepticus diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Background and purpose: The 2014 International League Against Epilepsy clinical definition of epilepsy allows diagnosis after a single unprovoked seizure if the 10‐year recurrence risk exceeds 60%. Multiple sclerosis (MS) carries an increased risk of epilepsy, but the risk after a first seizure is unknown. We aimed to investigate the risk of epilepsy in patients with MS who had suffered a first seizure. Methods: We cross‐referenced data from the Swedish MS register with the national patient register for 15 810 patients with MS and 43 635 controls and included 289 patients with MS and 222 controls with a first diagnosis of seizure or status epilepticus (SE) without prior epilepsy or presumed symptomatic aetiology. Kaplan–Meier curves were used to estimate the risk of epilepsy. Results: The 10‐year risk of epilepsy was 51.4% [95% confidence interval (CI), 44.0–58.9] for patients with MS and 41.3% (95% CI, 33.5–49.1) for controls. The risk was 46.1% (95% CI, 35.3–56.9) for patients with relapsing‐remitting MS and 60.7% (95% CI, 46.6–74.8) for patients with secondary progressive MS. For patients with MS with SE, the 10‐year risk of epilepsy was 85.9% (95% CI, 67.9–100). Conclusions: Our data indicate that patients with relapsing‐remitting MS have a similar risk as controls of developing epilepsy after a single seizure. Patients with secondary progressive MS could run a greater risk of subsequent epilepsy, but our data do not indicate a risk that, with certainty, exceeds the threshold specified by the International League Against Epilepsy. Patients with SE have a high risk of epilepsy, possibly motivating diagnosis and treatment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=129612044
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      – SubjectFull: Status epilepticus diagnosis
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              Text: Jun2018
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