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Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster‐analytic approach.

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Title: Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster‐analytic approach.
Authors: Solé, B., Bonnin, C. M., Jiménez, E., Torrent, C., Torres, I., Varo, C., Valls, E., Montejo, L., Gómez‐Ocaña, C., Tomioka, Y., Vieta, E., Martinez‐Aran, A., Reinares, M.
Source: Acta Psychiatrica Scandinavica. Jun2018, Vol. 137 Issue 6, p516-527. 12p. 4 Charts, 1 Graph.
Subjects: Bipolar disorder, Hierarchical clustering (Cluster analysis), Diagnosis of bipolar disorder, Symptoms, Psychosocial factors, Patients
Abstract: Objective: The aim was to examine the heterogeneity of psychosocial outcomes in euthymic bipolar disorder (BD) patients and analyse the potential influence of distinct variables on functioning. Method: Using a hierarchical cluster exploratory analysis, 143 euthymic patients with diagnosis of BD were grouped according to their functional performance based on domains scores of the Functioning Assessment Short Test (FAST). The resulting groups were compared on sociodemographic, clinical and neurocognitive variables to find factors associated with each functional cluster. Results: Patients were grouped in three functional profiles: patients with good functioning in all the FAST areas, patients with an intermediate profile showing great difficulties in the occupational domain and milder difficulties in most of the rest domains, and a third group with serious difficulties in almost all functional areas. Both functionally impaired groups were characterized by higher subthreshold symptoms (depressive and manic) and higher unemployment rates. The most functionally impaired group also showed lower scores on some measures of processing speed. Conclusion: Two of three functional profiles showed some kind of impairment which was associated with subsyndromal symptoms and cognitive performance. These patterns should be taken into consideration to develop more individualized interventions to restore, or improve, psychosocial outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster‐analytic approach.
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  Data: <searchLink fieldCode="AR" term="%22Solé%2C+B%2E%22">Solé, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Bonnin%2C+C%2E+M%2E%22">Bonnin, C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Jiménez%2C+E%2E%22">Jiménez, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Torrent%2C+C%2E%22">Torrent, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Torres%2C+I%2E%22">Torres, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Varo%2C+C%2E%22">Varo, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Valls%2C+E%2E%22">Valls, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Montejo%2C+L%2E%22">Montejo, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Gómez‐Ocaña%2C+C%2E%22">Gómez‐Ocaña, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Tomioka%2C+Y%2E%22">Tomioka, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Vieta%2C+E%2E%22">Vieta, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Martinez‐Aran%2C+A%2E%22">Martinez‐Aran, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Reinares%2C+M%2E%22">Reinares, M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jun2018, Vol. 137 Issue 6, p516-527. 12p. 4 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Hierarchical+clustering+%28Cluster+analysis%29%22">Hierarchical clustering (Cluster analysis)</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis+of+bipolar+disorder%22">Diagnosis of bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Objective: The aim was to examine the heterogeneity of psychosocial outcomes in euthymic bipolar disorder (BD) patients and analyse the potential influence of distinct variables on functioning. Method: Using a hierarchical cluster exploratory analysis, 143 euthymic patients with diagnosis of BD were grouped according to their functional performance based on domains scores of the Functioning Assessment Short Test (FAST). The resulting groups were compared on sociodemographic, clinical and neurocognitive variables to find factors associated with each functional cluster. Results: Patients were grouped in three functional profiles: patients with good functioning in all the FAST areas, patients with an intermediate profile showing great difficulties in the occupational domain and milder difficulties in most of the rest domains, and a third group with serious difficulties in almost all functional areas. Both functionally impaired groups were characterized by higher subthreshold symptoms (depressive and manic) and higher unemployment rates. The most functionally impaired group also showed lower scores on some measures of processing speed. Conclusion: Two of three functional profiles showed some kind of impairment which was associated with subsyndromal symptoms and cognitive performance. These patterns should be taken into consideration to develop more individualized interventions to restore, or improve, psychosocial outcomes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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