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Bilateral ischaemic lesions of the medial prefrontal cortex are anxiogenic in the rat.

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Title: Bilateral ischaemic lesions of the medial prefrontal cortex are anxiogenic in the rat.
Authors: Déziel, Robert A., Tasker, R. Andrew
Source: Acta Neuropsychiatrica. May2018, Vol. 30 Issue 3, p181-186. 6p.
Subjects: Prefrontal cortex, Rodents, Cognition, Stroke, Anxiety
Abstract: Objective: Stroke patients often suffer from delayed disturbances of mood and cognition. In rodents, the prefrontal cortex (PFC) is involved in both higher order cognition and emotion. Our objective was to determine if bilateral focal ischaemic lesions restricted to the medial prefrontal cortex (mPFC) could be used to model post-stroke anxiety and/or cognitive deficits. Methods: Groups of adult male Sprague-Dawley rats (n=9) received bilateral injections of either endothelin-1 (ET-1) (400 pmol) or vehicle (artificial cerebrospinal fluid) into the mPFC and were tested at various times using both a test of temporal order memory and in an elevated plus maze. Lesions were verified histologically. Results: ET-1 lesioned rats had reduced mobility on post-surgery day 8 that had resolved by day 29 at which time they spent significantly more time in the closed arm of the plus maze Conclusion: We conclude that ischaemic lesions localised to the mPFC can be used to model post-stroke anxiety in rats. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Bilateral ischaemic lesions of the medial prefrontal cortex are anxiogenic in the rat.
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  Data: <searchLink fieldCode="AR" term="%22Déziel%2C+Robert+A%2E%22">Déziel, Robert A.</searchLink><br /><searchLink fieldCode="AR" term="%22Tasker%2C+R%2E+Andrew%22">Tasker, R. Andrew</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neuropsychiatrica%22">Acta Neuropsychiatrica</searchLink>. May2018, Vol. 30 Issue 3, p181-186. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Rodents%22">Rodents</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Objective: Stroke patients often suffer from delayed disturbances of mood and cognition. In rodents, the prefrontal cortex (PFC) is involved in both higher order cognition and emotion. Our objective was to determine if bilateral focal ischaemic lesions restricted to the medial prefrontal cortex (mPFC) could be used to model post-stroke anxiety and/or cognitive deficits. Methods: Groups of adult male Sprague-Dawley rats (<italic>n</italic>=9) received bilateral injections of either endothelin-1 (ET-1) (400 pmol) or vehicle (artificial cerebrospinal fluid) into the mPFC and were tested at various times using both a test of temporal order memory and in an elevated plus maze. Lesions were verified histologically. Results: ET-1 lesioned rats had reduced mobility on post-surgery day 8 that had resolved by day 29 at which time they spent significantly more time in the closed arm of the plus maze Conclusion: We conclude that ischaemic lesions localised to the mPFC can be used to model post-stroke anxiety in rats. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/neu.2017.32
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        Text: English
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      – SubjectFull: Prefrontal cortex
        Type: general
      – SubjectFull: Rodents
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      – SubjectFull: Cognition
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      – SubjectFull: Stroke
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