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Cardiometabolic Risk Factors at 5 Years After Omega-3 Fatty Acid Supplementation in Infancy.

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Title: Cardiometabolic Risk Factors at 5 Years After Omega-3 Fatty Acid Supplementation in Infancy.
Authors: See, Valene H. L., Mori, Trevor A., Prescott, Susan L., Beilin, Lawrence J., Burrows, Sally, Math, B., Rae-Chi Huang
Source: Pediatrics. Jul2018, Vol. 142 Issue 1, p1-11. 11p.
Subjects: Metabolic disorders, Anthropometry, Biochemistry, Blood pressure, Body composition, Cardiovascular diseases risk factors, Confidence intervals, Dietary supplements, Fasting, Cord blood, Heart beat, Insulin, Insulin resistance, Olive oil, Omega-3 fatty acids, Randomized controlled trials, Adipokines, Waist circumference, Children, Disease risk factors
Abstract: BACKGROUND: Omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation during infancy may reduce adult cardiovascular risk as observed in animals. We assessed the effect of n-3 LCPUFA supplementation in infancy on growth, body composition, and cardiometabolic risk factors at 5 years of age. METHODS: Infants were randomly assigned to a daily supplement of n-3 LCPUFA or olive oil (control) from birth to 6 months (n = 420). Measurements included weight, length, cord blood adipokines at birth and anthropometry, skinfolds, blood pressure, heart rate, fasting blood adipokines, and biochemistry at 5 years. RESULTS: The infants who received n-3 LCPUFA had a smaller waist circumference at 5 years (coefficient: 1.1 cm; 95% confidence interval [CI]: 0.01 to 2.14), which remained significant after adjustments for confounders (coefficient: 0.8 cm; 95% CI: 0.19 to 1.30). Five-year-old boys who received n-3 LCPUFA supplementation as infants had a 21% reduction in insulin concentrations (ratio: 0.79; 95% CI: 0.66 to 0.94) and a 22% reduction in insulin resistance (ratio: 0.78; 95% CI: 0.64 to 0.95) compared with the control group. There were no other differences in growth and cardiometabolic risk factors between the groups for the whole cohort at birth, 2.5, or 5 years. CONCLUSIONS: Supplementation with n-3 LCPUFA in infancy revealed a reduction in waist circumference at 5 years. Boys in the n-3 LCPUFA group showed reduced insulin concentrations and insulin resistance at 5 years, which may have beneficial outcomes for later health. No effects were seen in girls. Longer term follow-up of the cohort is warranted to determine whether these differences are maintained into adolescence. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cardiometabolic Risk Factors at 5 Years After Omega-3 Fatty Acid Supplementation in Infancy.
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  Data: <searchLink fieldCode="AR" term="%22See%2C+Valene+H%2E+L%2E%22">See, Valene H. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Mori%2C+Trevor+A%2E%22">Mori, Trevor A.</searchLink><br /><searchLink fieldCode="AR" term="%22Prescott%2C+Susan+L%2E%22">Prescott, Susan L.</searchLink><br /><searchLink fieldCode="AR" term="%22Beilin%2C+Lawrence+J%2E%22">Beilin, Lawrence J.</searchLink><br /><searchLink fieldCode="AR" term="%22Burrows%2C+Sally%22">Burrows, Sally</searchLink><br /><searchLink fieldCode="AR" term="%22Math%2C+B%2E%22">Math, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Rae-Chi+Huang%22">Rae-Chi Huang</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Jul2018, Vol. 142 Issue 1, p1-11. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Metabolic+disorders%22">Metabolic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Anthropometry%22">Anthropometry</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Body+composition%22">Body composition</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases+risk+factors%22">Cardiovascular diseases risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Dietary+supplements%22">Dietary supplements</searchLink><br /><searchLink fieldCode="DE" term="%22Fasting%22">Fasting</searchLink><br /><searchLink fieldCode="DE" term="%22Cord+blood%22">Cord blood</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin%22">Insulin</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+resistance%22">Insulin resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Olive+oil%22">Olive oil</searchLink><br /><searchLink fieldCode="DE" term="%22Omega-3+fatty+acids%22">Omega-3 fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Adipokines%22">Adipokines</searchLink><br /><searchLink fieldCode="DE" term="%22Waist+circumference%22">Waist circumference</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation during infancy may reduce adult cardiovascular risk as observed in animals. We assessed the effect of n-3 LCPUFA supplementation in infancy on growth, body composition, and cardiometabolic risk factors at 5 years of age. METHODS: Infants were randomly assigned to a daily supplement of n-3 LCPUFA or olive oil (control) from birth to 6 months (n = 420). Measurements included weight, length, cord blood adipokines at birth and anthropometry, skinfolds, blood pressure, heart rate, fasting blood adipokines, and biochemistry at 5 years. RESULTS: The infants who received n-3 LCPUFA had a smaller waist circumference at 5 years (coefficient: 1.1 cm; 95% confidence interval [CI]: 0.01 to 2.14), which remained significant after adjustments for confounders (coefficient: 0.8 cm; 95% CI: 0.19 to 1.30). Five-year-old boys who received n-3 LCPUFA supplementation as infants had a 21% reduction in insulin concentrations (ratio: 0.79; 95% CI: 0.66 to 0.94) and a 22% reduction in insulin resistance (ratio: 0.78; 95% CI: 0.64 to 0.95) compared with the control group. There were no other differences in growth and cardiometabolic risk factors between the groups for the whole cohort at birth, 2.5, or 5 years. CONCLUSIONS: Supplementation with n-3 LCPUFA in infancy revealed a reduction in waist circumference at 5 years. Boys in the n-3 LCPUFA group showed reduced insulin concentrations and insulin resistance at 5 years, which may have beneficial outcomes for later health. No effects were seen in girls. Longer term follow-up of the cohort is warranted to determine whether these differences are maintained into adolescence. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2016-2623
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: Metabolic disorders
        Type: general
      – SubjectFull: Anthropometry
        Type: general
      – SubjectFull: Biochemistry
        Type: general
      – SubjectFull: Blood pressure
        Type: general
      – SubjectFull: Body composition
        Type: general
      – SubjectFull: Cardiovascular diseases risk factors
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Dietary supplements
        Type: general
      – SubjectFull: Fasting
        Type: general
      – SubjectFull: Cord blood
        Type: general
      – SubjectFull: Heart beat
        Type: general
      – SubjectFull: Insulin
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      – SubjectFull: Insulin resistance
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      – SubjectFull: Olive oil
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      – SubjectFull: Omega-3 fatty acids
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Adipokines
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      – SubjectFull: Waist circumference
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      – SubjectFull: Children
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
    Titles:
      – TitleFull: Cardiometabolic Risk Factors at 5 Years After Omega-3 Fatty Acid Supplementation in Infancy.
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              Text: Jul2018
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