View in EDS

Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.

Saved in:
Bibliographic Details
Title: Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.
Authors: Hibar, Derrek P., Cheung, Joshua W., Medland, Sarah E., Mufford, Mary S., Jahanshad, Neda, Dalvie, Shareefa, Ramesar, Raj, Stewart, Evelyn, van den Heuvel, Odile A., Pauls, David L., Knowles, James A., Stein, Dan J., Thompson, Paul M., Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Consortium and International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) (CORPORATE AUTHOR)
Source: British Journal of Psychiatry. Jul2018, Vol. 213 Issue 1, p430-436. 7p.
Subjects: Human genetic variation, Obsessive-compulsive disorder, Nucleus accumbens, Single nucleotide polymorphisms, Amygdaloid body, Neurobehavioral disorders
Abstract: Background: Many studies have identified changes in the brain associated with obsessive-compulsive disorder (OCD), but few have examined the relationship between genetic determinants of OCD and brain variation.AimsWe present the first genome-wide investigation of overlapping genetic risk for OCD and genetic influences on subcortical brain structures.Method: Using single nucleotide polymorphism effect concordance analysis, we measured genetic overlap between the first genome-wide association study (GWAS) of OCD (1465 participants with OCD, 5557 controls) and recent GWASs of eight subcortical brain volumes (13 171 participants).Results: We found evidence of significant positive concordance between OCD risk variants and variants associated with greater nucleus accumbens and putamen volumes. When conditioning OCD risk variants on brain volume, variants influencing putamen, amygdala and thalamus volumes were associated with risk for OCD.Conclusions: These results are consistent with current OCD neurocircuitry models. Further evidence will clarify the relationship between putamen volume and OCD risk, and the roles of the detected variants in this disorder.Declaration of interestThe authors have declared that no competing interests exist. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 130466784
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hibar%2C+Derrek+P%2E%22">Hibar, Derrek P.</searchLink><br /><searchLink fieldCode="AR" term="%22Cheung%2C+Joshua+W%2E%22">Cheung, Joshua W.</searchLink><br /><searchLink fieldCode="AR" term="%22Medland%2C+Sarah+E%2E%22">Medland, Sarah E.</searchLink><br /><searchLink fieldCode="AR" term="%22Mufford%2C+Mary+S%2E%22">Mufford, Mary S.</searchLink><br /><searchLink fieldCode="AR" term="%22Jahanshad%2C+Neda%22">Jahanshad, Neda</searchLink><br /><searchLink fieldCode="AR" term="%22Dalvie%2C+Shareefa%22">Dalvie, Shareefa</searchLink><br /><searchLink fieldCode="AR" term="%22Ramesar%2C+Raj%22">Ramesar, Raj</searchLink><br /><searchLink fieldCode="AR" term="%22Stewart%2C+Evelyn%22">Stewart, Evelyn</searchLink><br /><searchLink fieldCode="AR" term="%22van+den+Heuvel%2C+Odile+A%2E%22">van den Heuvel, Odile A.</searchLink><br /><searchLink fieldCode="AR" term="%22Pauls%2C+David+L%2E%22">Pauls, David L.</searchLink><br /><searchLink fieldCode="AR" term="%22Knowles%2C+James+A%2E%22">Knowles, James A.</searchLink><br /><searchLink fieldCode="AR" term="%22Stein%2C+Dan+J%2E%22">Stein, Dan J.</searchLink><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Paul+M%2E%22">Thompson, Paul M.</searchLink><br /><searchLink fieldCode="AR" term="%22Enhancing+Neuro+Imaging+Genetics+through+Meta+Analysis+%28ENIGMA%29+Consortium+and+International+Obsessive+Compulsive+Disorder+Foundation+Genetics+Collaborative+%28IOCDF-GC%29%22">Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Consortium and International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC)</searchLink> (CORPORATE AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jul2018, Vol. 213 Issue 1, p430-436. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Human+genetic+variation%22">Human genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleus+accumbens%22">Nucleus accumbens</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobehavioral+disorders%22">Neurobehavioral disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>Many studies have identified changes in the brain associated with obsessive-compulsive disorder (OCD), but few have examined the relationship between genetic determinants of OCD and brain variation.AimsWe present the first genome-wide investigation of overlapping genetic risk for OCD and genetic influences on subcortical brain structures.<bold>Method: </bold>Using single nucleotide polymorphism effect concordance analysis, we measured genetic overlap between the first genome-wide association study (GWAS) of OCD (1465 participants with OCD, 5557 controls) and recent GWASs of eight subcortical brain volumes (13 171 participants).<bold>Results: </bold>We found evidence of significant positive concordance between OCD risk variants and variants associated with greater nucleus accumbens and putamen volumes. When conditioning OCD risk variants on brain volume, variants influencing putamen, amygdala and thalamus volumes were associated with risk for OCD.<bold>Conclusions: </bold>These results are consistent with current OCD neurocircuitry models. Further evidence will clarify the relationship between putamen volume and OCD risk, and the roles of the detected variants in this disorder.Declaration of interestThe authors have declared that no competing interests exist. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=130466784
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1192/bjp.2018.62
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 430
    Subjects:
      – SubjectFull: Human genetic variation
        Type: general
      – SubjectFull: Obsessive-compulsive disorder
        Type: general
      – SubjectFull: Nucleus accumbens
        Type: general
      – SubjectFull: Single nucleotide polymorphisms
        Type: general
      – SubjectFull: Amygdaloid body
        Type: general
      – SubjectFull: Neurobehavioral disorders
        Type: general
    Titles:
      – TitleFull: Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hibar, Derrek P.
      – PersonEntity:
          Name:
            NameFull: Cheung, Joshua W.
      – PersonEntity:
          Name:
            NameFull: Medland, Sarah E.
      – PersonEntity:
          Name:
            NameFull: Mufford, Mary S.
      – PersonEntity:
          Name:
            NameFull: Jahanshad, Neda
      – PersonEntity:
          Name:
            NameFull: Dalvie, Shareefa
      – PersonEntity:
          Name:
            NameFull: Ramesar, Raj
      – PersonEntity:
          Name:
            NameFull: Stewart, Evelyn
      – PersonEntity:
          Name:
            NameFull: van den Heuvel, Odile A.
      – PersonEntity:
          Name:
            NameFull: Pauls, David L.
      – PersonEntity:
          Name:
            NameFull: Knowles, James A.
      – PersonEntity:
          Name:
            NameFull: Stein, Dan J.
      – PersonEntity:
          Name:
            NameFull: Thompson, Paul M.
      – PersonEntity:
          Name:
            NameFull: Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Consortium and International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC)
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 00071250
          Numbering:
            – Type: volume
              Value: 213
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: British Journal of Psychiatry
              Type: main
ResultId 1