Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register.
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| Title: | Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. |
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| Authors: | Vernal, Ditte Lammers, Stenstrøm, Anne Dorte, Staal, Nina, Christensen, Anne Marie Raabjerg, Ebbesen, Christine, Pagsberg, Anne Katrine, Correll, Christoph U., Nielsen, René Ernst, Lauritsen, Marlene Briciet |
| Source: | European Child & Adolescent Psychiatry. Aug2018, Vol. 27 Issue 8, p965-975. 11p. 2 Diagrams, 3 Charts. |
| Subjects: | Diagnosis of schizophrenia, Age factors in disease, Diagnostic errors, Reporting of diseases, Outpatient services in hospitals, Nosology, Research evaluation, Statistics, Inter-observer reliability |
| Geographic Terms: | Denmark |
| Abstract: | The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses. Psychiatric records from 200 patients with a first-time diagnosis of schizophrenia (F20.x) at age < 18 years between 1994 and 2009 in the DPCRR were rated by experienced clinicians according to ICD-10 criteria, using a predefined checklist. We retrieved 178 records, representing 19.6% of all patients diagnosed with EOS from 1994 to 2009. Mean age was 15.2 years and 56.2% were males. The register-based and clinical diagnoses matched in 158 cases (88.8%). Raters’ diagnoses confirmed the DPCRR schizophrenia diagnoses in 134 cases, rendering a diagnostic validity of 75.3% of DPCRR schizophrenia, while 149 cases were confirmed as being in the schizophrenia spectrum (83.7%). When removing records with registration errors, 83.5% of cases were confirmed as schizophrenia and 91.8% as being in the schizophrenia spectrum. Interrater reliability was substantial with Cohen’s kappa > 0.78-0.83 depending on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS. [ABSTRACT FROM AUTHOR] |
| Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 130842457 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vernal%2C+Ditte+Lammers%22">Vernal, Ditte Lammers</searchLink><br /><searchLink fieldCode="AR" term="%22Stenstrøm%2C+Anne+Dorte%22">Stenstrøm, Anne Dorte</searchLink><br /><searchLink fieldCode="AR" term="%22Staal%2C+Nina%22">Staal, Nina</searchLink><br /><searchLink fieldCode="AR" term="%22Christensen%2C+Anne+Marie+Raabjerg%22">Christensen, Anne Marie Raabjerg</searchLink><br /><searchLink fieldCode="AR" term="%22Ebbesen%2C+Christine%22">Ebbesen, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Pagsberg%2C+Anne+Katrine%22">Pagsberg, Anne Katrine</searchLink><br /><searchLink fieldCode="AR" term="%22Correll%2C+Christoph+U%2E%22">Correll, Christoph U.</searchLink><br /><searchLink fieldCode="AR" term="%22Nielsen%2C+René+Ernst%22">Nielsen, René Ernst</searchLink><br /><searchLink fieldCode="AR" term="%22Lauritsen%2C+Marlene+Briciet%22">Lauritsen, Marlene Briciet</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Aug2018, Vol. 27 Issue 8, p965-975. 11p. 2 Diagrams, 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+schizophrenia%22">Diagnosis of schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Age+factors+in+disease%22">Age factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+errors%22">Diagnostic errors</searchLink><br /><searchLink fieldCode="DE" term="%22Reporting+of+diseases%22">Reporting of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Outpatient+services+in+hospitals%22">Outpatient services in hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22Nosology%22">Nosology</searchLink><br /><searchLink fieldCode="DE" term="%22Research+evaluation%22">Research evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Inter-observer+reliability%22">Inter-observer reliability</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Denmark%22">Denmark</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses. Psychiatric records from 200 patients with a first-time diagnosis of schizophrenia (F20.x) at age < 18 years between 1994 and 2009 in the DPCRR were rated by experienced clinicians according to ICD-10 criteria, using a predefined checklist. We retrieved 178 records, representing 19.6% of all patients diagnosed with EOS from 1994 to 2009. Mean age was 15.2 years and 56.2% were males. The register-based and clinical diagnoses matched in 158 cases (88.8%). Raters’ diagnoses confirmed the DPCRR schizophrenia diagnoses in 134 cases, rendering a diagnostic validity of 75.3% of DPCRR schizophrenia, while 149 cases were confirmed as being in the schizophrenia spectrum (83.7%). When removing records with registration errors, 83.5% of cases were confirmed as schizophrenia and 91.8% as being in the schizophrenia spectrum. Interrater reliability was substantial with Cohen’s kappa > 0.78-0.83 depending on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00787-017-1102-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 965 Subjects: – SubjectFull: Diagnosis of schizophrenia Type: general – SubjectFull: Age factors in disease Type: general – SubjectFull: Diagnostic errors Type: general – SubjectFull: Reporting of diseases Type: general – SubjectFull: Outpatient services in hospitals Type: general – SubjectFull: Nosology Type: general – SubjectFull: Research evaluation Type: general – SubjectFull: Statistics Type: general – SubjectFull: Inter-observer reliability Type: general – SubjectFull: Denmark Type: general Titles: – TitleFull: Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vernal, Ditte Lammers – PersonEntity: Name: NameFull: Stenstrøm, Anne Dorte – PersonEntity: Name: NameFull: Staal, Nina – PersonEntity: Name: NameFull: Christensen, Anne Marie Raabjerg – PersonEntity: Name: NameFull: Ebbesen, Christine – PersonEntity: Name: NameFull: Pagsberg, Anne Katrine – PersonEntity: Name: NameFull: Correll, Christoph U. – PersonEntity: Name: NameFull: Nielsen, René Ernst – PersonEntity: Name: NameFull: Lauritsen, Marlene Briciet IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 10188827 Numbering: – Type: volume Value: 27 – Type: issue Value: 8 Titles: – TitleFull: European Child & Adolescent Psychiatry Type: main |
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