View in EDS HTML Full Text PDF Full Text

Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.

Saved in:
Bibliographic Details
Title: Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.
Authors: Kowalczyk, William J., Moran, Landhing M., Bertz, Jeremiah W., Phillips, Karran A., Ghitza, Udi E., Vahabzadeh, Massoud, Lin, Jia-Ling, Epstein, David H., Preston, Kenzie L.
Source: American Journal of Drug & Alcohol Abuse. 2018, Vol. 44 Issue 5, p502-511. 10p.
Subjects: Opioid abuse, Drug abuse prevention, Ecological momentary assessments (Clinical psychology), Marijuana abuse, Treatment of addictions, Clonidine, Buprenorphine
Abstract: Background: In a recent clinical trial (NCT00295308), we demonstrated that clonidine decreased the association between opioid craving and moderate levels of stress and affect in patients receiving buprenorphine-based opioid agonist therapy.Objectives: To examine the relationship between illicit opioid use and craving and affect during the evaluation of clonidine as an adjunct medication in buprenorphine treatment for opioid use disorder. Secondarily, to examine whether those relationships are driven by within- or between-participant factors.Methods: This was a secondary data analysis from our original trial. Participants (N = 108, female: n = 23, male n = 85) receiving buprenorphine were randomized to receive adjunct clonidine or placebo. Participants used portable electronic devices to rate stress, mood, and craving via ecological momentary assessment (EMA) four times randomly each day. To associate the EMA data with illicit opioid use, each EMA report was linked to participants' next urine drug screen (thrice weekly). We used generalized linear mixed models to examine the interaction between treatment group and illicit opioid use, as well as to decompose the analysis into within- and between-participant effects.Results: Craving for opioids and cocaine was increased when participants were using illicit opioids; this effect was greater in the clonidine group. For affect, mood was poorer during periods preceding opioid-positive urines than opioid-negative urines for clonidine-treated participants, whereas there was no difference for placebo participants.Conclusion: This secondary analysis provides evidence that for participants maintained on opioid agonist therapy, clonidine minimized the behavioral impact of moderate levels of negative affect and craving. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 130934915
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kowalczyk%2C+William+J%2E%22">Kowalczyk, William J.</searchLink><br /><searchLink fieldCode="AR" term="%22Moran%2C+Landhing+M%2E%22">Moran, Landhing M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bertz%2C+Jeremiah+W%2E%22">Bertz, Jeremiah W.</searchLink><br /><searchLink fieldCode="AR" term="%22Phillips%2C+Karran+A%2E%22">Phillips, Karran A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ghitza%2C+Udi+E%2E%22">Ghitza, Udi E.</searchLink><br /><searchLink fieldCode="AR" term="%22Vahabzadeh%2C+Massoud%22">Vahabzadeh, Massoud</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Jia-Ling%22">Lin, Jia-Ling</searchLink><br /><searchLink fieldCode="AR" term="%22Epstein%2C+David+H%2E%22">Epstein, David H.</searchLink><br /><searchLink fieldCode="AR" term="%22Preston%2C+Kenzie+L%2E%22">Preston, Kenzie L.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Drug+%26+Alcohol+Abuse%22">American Journal of Drug & Alcohol Abuse</searchLink>. 2018, Vol. 44 Issue 5, p502-511. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Opioid+abuse%22">Opioid abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse+prevention%22">Drug abuse prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Ecological+momentary+assessments+%28Clinical+psychology%29%22">Ecological momentary assessments (Clinical psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Marijuana+abuse%22">Marijuana abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+addictions%22">Treatment of addictions</searchLink><br /><searchLink fieldCode="DE" term="%22Clonidine%22">Clonidine</searchLink><br /><searchLink fieldCode="DE" term="%22Buprenorphine%22">Buprenorphine</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>In a recent clinical trial (NCT00295308), we demonstrated that clonidine decreased the association between opioid craving and moderate levels of stress and affect in patients receiving buprenorphine-based opioid agonist therapy.<bold>Objectives: </bold>To examine the relationship between illicit opioid use and craving and affect during the evaluation of clonidine as an adjunct medication in buprenorphine treatment for opioid use disorder. Secondarily, to examine whether those relationships are driven by within- or between-participant factors.<bold>Methods: </bold>This was a secondary data analysis from our original trial. Participants (N = 108, female: n = 23, male n = 85) receiving buprenorphine were randomized to receive adjunct clonidine or placebo. Participants used portable electronic devices to rate stress, mood, and craving via ecological momentary assessment (EMA) four times randomly each day. To associate the EMA data with illicit opioid use, each EMA report was linked to participants' next urine drug screen (thrice weekly). We used generalized linear mixed models to examine the interaction between treatment group and illicit opioid use, as well as to decompose the analysis into within- and between-participant effects.<bold>Results: </bold>Craving for opioids and cocaine was increased when participants were using illicit opioids; this effect was greater in the clonidine group. For affect, mood was poorer during periods preceding opioid-positive urines than opioid-negative urines for clonidine-treated participants, whereas there was no difference for placebo participants.<bold>Conclusion: </bold>This secondary analysis provides evidence that for participants maintained on opioid agonist therapy, clonidine minimized the behavioral impact of moderate levels of negative affect and craving. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=130934915
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00952990.2018.1454933
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 502
    Subjects:
      – SubjectFull: Opioid abuse
        Type: general
      – SubjectFull: Drug abuse prevention
        Type: general
      – SubjectFull: Ecological momentary assessments (Clinical psychology)
        Type: general
      – SubjectFull: Marijuana abuse
        Type: general
      – SubjectFull: Treatment of addictions
        Type: general
      – SubjectFull: Clonidine
        Type: general
      – SubjectFull: Buprenorphine
        Type: general
    Titles:
      – TitleFull: Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kowalczyk, William J.
      – PersonEntity:
          Name:
            NameFull: Moran, Landhing M.
      – PersonEntity:
          Name:
            NameFull: Bertz, Jeremiah W.
      – PersonEntity:
          Name:
            NameFull: Phillips, Karran A.
      – PersonEntity:
          Name:
            NameFull: Ghitza, Udi E.
      – PersonEntity:
          Name:
            NameFull: Vahabzadeh, Massoud
      – PersonEntity:
          Name:
            NameFull: Lin, Jia-Ling
      – PersonEntity:
          Name:
            NameFull: Epstein, David H.
      – PersonEntity:
          Name:
            NameFull: Preston, Kenzie L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: 2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 00952990
          Numbering:
            – Type: volume
              Value: 44
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: American Journal of Drug & Alcohol Abuse
              Type: main
ResultId 1