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Sex differences in daily life stress and craving in opioid-dependent patients.

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Title: Sex differences in daily life stress and craving in opioid-dependent patients.
Authors: Moran, Landhing M., Kowalczyk, William J., Phillips, Karran A., Vahabzadeh, Massoud, Lin, Jia-Ling, Mezghanni, Mustapha, Epstein, David H., Preston, Kenzie L.
Source: American Journal of Drug & Alcohol Abuse. 2018, Vol. 44 Issue 5, p512-523. 12p.
Subjects: Drug abuse prevention, Opioid abuse, Marijuana abuse, Treatment of addictions, Gender specific care
Abstract: Background: Responses to stress and drug craving differ between men and women. Differences in the momentary experience of stress in relation to craving are less well-understood.Objectives: Using ecological momentary assessment (EMA), we examined sex differences in real-time in two areas: (1) causes and contexts associated with stress, and (2) the extent to which stress and drug cues are associated with craving.Methods: Outpatients on opioid-agonist treatment (135 males, 47 females) reported stress, craving, and behavior on smartphones for 16 weeks. They initiated an entry each time they felt more stressed than usual (stress event) and made randomly prompted entries 3 times/day. In stress-event entries, they identified the causes and context (location, activity, companions), and rated stress and craving severity.Results: The causes reported for stress events did not differ significantly by sex. Women reported arguing and being in a store more often during stress events, and men reported working more often during stress events, compared to base rates (assessed via random prompts). Women showed a greater increase in opioid craving as a function of stress (p < 0.0001) and had higher stress ratings in the presence of both stress and drug cues relative to men (p < 0.01). Similar effects were found for cocaine craving in men (p < 0.0001).Conclusion: EMA methods provide evidence based on real-time activities and moods that opioid-dependent men and women experience similar contexts and causes for stress but differ in stress- and cue-induced craving. These findings support sex-based tailoring of treatment, but because not all participants conformed to the overall pattern of sex differences, any such tailoring should also consider person-level differences. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sex differences in daily life stress and craving in opioid-dependent patients.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Moran%2C+Landhing+M%2E%22&quot;&gt;Moran, Landhing M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kowalczyk%2C+William+J%2E%22&quot;&gt;Kowalczyk, William J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Phillips%2C+Karran+A%2E%22&quot;&gt;Phillips, Karran A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vahabzadeh%2C+Massoud%22&quot;&gt;Vahabzadeh, Massoud&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Jia-Ling%22&quot;&gt;Lin, Jia-Ling&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mezghanni%2C+Mustapha%22&quot;&gt;Mezghanni, Mustapha&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Epstein%2C+David+H%2E%22&quot;&gt;Epstein, David H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Preston%2C+Kenzie+L%2E%22&quot;&gt;Preston, Kenzie L.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22American+Journal+of+Drug+%26+Alcohol+Abuse%22&quot;&gt;American Journal of Drug &amp; Alcohol Abuse&lt;/searchLink&gt;. 2018, Vol. 44 Issue 5, p512-523. 12p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+abuse+prevention%22&quot;&gt;Drug abuse prevention&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Opioid+abuse%22&quot;&gt;Opioid abuse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Marijuana+abuse%22&quot;&gt;Marijuana abuse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Treatment+of+addictions%22&quot;&gt;Treatment of addictions&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gender+specific+care%22&quot;&gt;Gender specific care&lt;/searchLink&gt;
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  Data: &lt;bold&gt;Background: &lt;/bold&gt;Responses to stress and drug craving differ between men and women. Differences in the momentary experience of stress in relation to craving are less well-understood.&lt;bold&gt;Objectives: &lt;/bold&gt;Using ecological momentary assessment (EMA), we examined sex differences in real-time in two areas: (1) causes and contexts associated with stress, and (2) the extent to which stress and drug cues are associated with craving.&lt;bold&gt;Methods: &lt;/bold&gt;Outpatients on opioid-agonist treatment (135 males, 47 females) reported stress, craving, and behavior on smartphones for 16&#160;weeks. They initiated an entry each time they felt more stressed than usual (stress event) and made randomly prompted entries 3 times/day. In stress-event entries, they identified the causes and context (location, activity, companions), and rated stress and craving severity.&lt;bold&gt;Results: &lt;/bold&gt;The causes reported for stress events did not differ significantly by sex. Women reported arguing and being in a store more often during stress events, and men reported working more often during stress events, compared to base rates (assessed via random prompts). Women showed a greater increase in opioid craving as a function of stress (p&#160;&lt;&#160;0.0001) and had higher stress ratings in the presence of both stress and drug cues relative to men (p&#160;&lt;&#160;0.01). Similar effects were found for cocaine craving in men (p&#160;&lt;&#160;0.0001).&lt;bold&gt;Conclusion: &lt;/bold&gt;EMA methods provide evidence based on real-time activities and moods that opioid-dependent men and women experience similar contexts and causes for stress but differ in stress- and cue-induced craving. These findings support sex-based tailoring of treatment, but because not all participants conformed to the overall pattern of sex differences, any such tailoring should also consider person-level differences. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of American Journal of Drug &amp; Alcohol Abuse is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=130934916
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      – Type: doi
        Value: 10.1080/00952990.2018.1454934
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      – Code: eng
        Text: English
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        PageCount: 12
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    Subjects:
      – SubjectFull: Drug abuse prevention
        Type: general
      – SubjectFull: Opioid abuse
        Type: general
      – SubjectFull: Marijuana abuse
        Type: general
      – SubjectFull: Treatment of addictions
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      – SubjectFull: Gender specific care
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      – TitleFull: Sex differences in daily life stress and craving in opioid-dependent patients.
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              Text: 2018
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