Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing.
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| Title: | Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing. |
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| Authors: | Hochgerner, Hannah, Zeisel, Amit, Lönnerberg, Peter, Linnarsson, Sten |
| Source: | Nature Neuroscience. Feb2018, Vol. 21 Issue 2, p290-299. 10p. 6 Graphs. |
| Abstract: | The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into adulthood; however, the relationship between developmental and adult dentate gyrus neurogenesis has not been examined in detail. Here we used single-cell RNA sequencing to reveal the molecular dynamics and diversity of dentate gyrus cell types in perinatal, juvenile, and adult mice. We found distinct quiescent and proliferating progenitor cell types, linked by transient intermediate states to neuroblast stages and fully mature granule cells. We observed shifts in the molecular identity of quiescent and proliferating radial glia and granule cells during the postnatal period that were then maintained through adult stages. In contrast, intermediate progenitor cells, neuroblasts, and immature granule cells were nearly indistinguishable at all ages. These findings demonstrate the fundamental similarity of postnatal and adult neurogenesis in the hippocampus and pinpoint the early postnatal transformation of radial glia from embryonic progenitors to adult quiescent stem cells. Using single-cell RNA-seq, the authors show that early developmental neurogenesis in the dentate gyrus of the hippocampus is largely conserved in the adult, but with a perinatal transformation of stem cells to an adult type. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 131022699 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hochgerner%2C+Hannah%22">Hochgerner, Hannah</searchLink><br /><searchLink fieldCode="AR" term="%22Zeisel%2C+Amit%22">Zeisel, Amit</searchLink><br /><searchLink fieldCode="AR" term="%22Lönnerberg%2C+Peter%22">Lönnerberg, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Linnarsson%2C+Sten%22">Linnarsson, Sten</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Feb2018, Vol. 21 Issue 2, p290-299. 10p. 6 Graphs. – Name: Abstract Label: Abstract Group: Ab Data: The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into adulthood; however, the relationship between developmental and adult dentate gyrus neurogenesis has not been examined in detail. Here we used single-cell RNA sequencing to reveal the molecular dynamics and diversity of dentate gyrus cell types in perinatal, juvenile, and adult mice. We found distinct quiescent and proliferating progenitor cell types, linked by transient intermediate states to neuroblast stages and fully mature granule cells. We observed shifts in the molecular identity of quiescent and proliferating radial glia and granule cells during the postnatal period that were then maintained through adult stages. In contrast, intermediate progenitor cells, neuroblasts, and immature granule cells were nearly indistinguishable at all ages. These findings demonstrate the fundamental similarity of postnatal and adult neurogenesis in the hippocampus and pinpoint the early postnatal transformation of radial glia from embryonic progenitors to adult quiescent stem cells. Using single-cell RNA-seq, the authors show that early developmental neurogenesis in the dentate gyrus of the hippocampus is largely conserved in the adult, but with a perinatal transformation of stem cells to an adult type. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41593-017-0056-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 290 Titles: – TitleFull: Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hochgerner, Hannah – PersonEntity: Name: NameFull: Zeisel, Amit – PersonEntity: Name: NameFull: Lönnerberg, Peter – PersonEntity: Name: NameFull: Linnarsson, Sten IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 21 – Type: issue Value: 2 Titles: – TitleFull: Nature Neuroscience Type: main |
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