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Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables.

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Title: Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables.
Authors: Sanchez-Moreno, J., Bonnin, C. M., González-Pinto, A., Amann, B. L., Solé, B., Balanzá-Martinez, V., Arango, C., Jiménez, E., Tabarés-Seisdedos, R., Garcia-Portilla, M. P., Ibáñez, A., Crespo, J. M., Ayuso-Mateos, J. L., Martinez-Aran, A., Torrent, C., Vieta, E.
Source: Acta Psychiatrica Scandinavica. Aug2018, Vol. 138 Issue 2, p145-154. 10p.
Subjects: Multiple correspondence analysis (Statistics), Sociodemographic factors, Mental health services, Bipolar disorder, Therapeutics, Patients
Abstract: Objective: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. Methods: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. Results: The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM-D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. Conclusions: Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables.
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  Data: <searchLink fieldCode="AR" term="%22Sanchez-Moreno%2C+J%2E%22">Sanchez-Moreno, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Bonnin%2C+C%2E+M%2E%22">Bonnin, C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22González-Pinto%2C+A%2E%22">González-Pinto, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Amann%2C+B%2E+L%2E%22">Amann, B. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Solé%2C+B%2E%22">Solé, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Balanzá-Martinez%2C+V%2E%22">Balanzá-Martinez, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Arango%2C+C%2E%22">Arango, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Jiménez%2C+E%2E%22">Jiménez, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Tabarés-Seisdedos%2C+R%2E%22">Tabarés-Seisdedos, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Garcia-Portilla%2C+M%2E+P%2E%22">Garcia-Portilla, M. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Ibáñez%2C+A%2E%22">Ibáñez, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Crespo%2C+J%2E+M%2E%22">Crespo, J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ayuso-Mateos%2C+J%2E+L%2E%22">Ayuso-Mateos, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Martinez-Aran%2C+A%2E%22">Martinez-Aran, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Torrent%2C+C%2E%22">Torrent, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Vieta%2C+E%2E%22">Vieta, E.</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Multiple+correspondence+analysis+%28Statistics%29%22">Multiple correspondence analysis (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Sociodemographic+factors%22">Sociodemographic factors</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+services%22">Mental health services</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Objective: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. Methods: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. Results: The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM-D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. Conclusions: Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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