Remodeling of the number and structure of dendritic spines in the medial amygdala: From prepubertal sexual dimorphism to puberty and effect of sexual experience in male rats.
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| Title: | Remodeling of the number and structure of dendritic spines in the medial amygdala: From prepubertal sexual dimorphism to puberty and effect of sexual experience in male rats. |
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| Authors: | Zancan, Mariana, da Cunha, Rick Shandler R., Schroeder, Francielle, Xavier, Léder L., Rasia‐Filho, Alberto A. |
| Source: | European Journal of Neuroscience. Jul2018, Vol. 48 Issue 2, p1851-1865. 15p. 1 Color Photograph, 2 Black and White Photographs, 4 Graphs. |
| Subjects: | Sexual dimorphism, Dendritic spines, Amygdaloid body, Confocal microscopy, Rat behavior, Neuroplasticity |
| Abstract: | Abstract: The posterodorsal medial amygdala (MePD) is a sexually dimorphic area and plays a central role in the social behavior network of rats. Dendritic spines modulate synaptic processing and plasticity. Here, we compared the number and structure of dendritic spines in the MePD of prepubertal males and females and postpubertal males with and without sexual experience. Spines were classified and measured after three‐dimensional image reconstruction using DiI fluorescent labeling and confocal microscopy. Significantly differences are as follows: (a) Prepubertal males have more proximal spines, stubby/wide spines with long length and large head diameter and thin and mushroom spines with wide neck and head diameters than prepubertal females, whereas (b) prepubertal females have more mushroom spines with long neck length than age‐matched males. (c) In males, the number of thin spines reduces after puberty and, compared to sexually experienced counterparts, (d) naive males have short stubby/wide spines as well as mushroom spines with reduced neck diameter. In addition, (e) sexually experienced males have an increase in the number of mushroom spines, the length of stubby/wide spines, the head diameter of thin and stubby/wide spines and the neck diameter of thin and mushroom spines. These data indicate that a sexual dimorphism in the MePD dendritic spines is evident before adulthood and a spine‐specific remodeling of number and shape can be brought about by both puberty and sexual experience. These fine‐tuned ontogenetic, hormonally and experience‐dependent changes in the MePD are relevant for plastic synaptic processing and the reproductive behavior of adult rats. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 131115847 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Remodeling of the number and structure of dendritic spines in the medial amygdala: From prepubertal sexual dimorphism to puberty and effect of sexual experience in male rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zancan%2C+Mariana%22">Zancan, Mariana</searchLink><br /><searchLink fieldCode="AR" term="%22da+Cunha%2C+Rick+Shandler+R%2E%22">da Cunha, Rick Shandler R.</searchLink><br /><searchLink fieldCode="AR" term="%22Schroeder%2C+Francielle%22">Schroeder, Francielle</searchLink><br /><searchLink fieldCode="AR" term="%22Xavier%2C+Léder+L%2E%22">Xavier, Léder L.</searchLink><br /><searchLink fieldCode="AR" term="%22Rasia‐Filho%2C+Alberto+A%2E%22">Rasia‐Filho, Alberto A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jul2018, Vol. 48 Issue 2, p1851-1865. 15p. 1 Color Photograph, 2 Black and White Photographs, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Sexual+dimorphism%22">Sexual dimorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Dendritic+spines%22">Dendritic spines</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Confocal+microscopy%22">Confocal microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Rat+behavior%22">Rat behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: The posterodorsal medial amygdala (MePD) is a sexually dimorphic area and plays a central role in the social behavior network of rats. Dendritic spines modulate synaptic processing and plasticity. Here, we compared the number and structure of dendritic spines in the MePD of prepubertal males and females and postpubertal males with and without sexual experience. Spines were classified and measured after three‐dimensional image reconstruction using DiI fluorescent labeling and confocal microscopy. Significantly differences are as follows: (a) Prepubertal males have more proximal spines, stubby/wide spines with long length and large head diameter and thin and mushroom spines with wide neck and head diameters than prepubertal females, whereas (b) prepubertal females have more mushroom spines with long neck length than age‐matched males. (c) In males, the number of thin spines reduces after puberty and, compared to sexually experienced counterparts, (d) naive males have short stubby/wide spines as well as mushroom spines with reduced neck diameter. In addition, (e) sexually experienced males have an increase in the number of mushroom spines, the length of stubby/wide spines, the head diameter of thin and stubby/wide spines and the neck diameter of thin and mushroom spines. These data indicate that a sexual dimorphism in the MePD dendritic spines is evident before adulthood and a spine‐specific remodeling of number and shape can be brought about by both puberty and sexual experience. These fine‐tuned ontogenetic, hormonally and experience‐dependent changes in the MePD are relevant for plastic synaptic processing and the reproductive behavior of adult rats. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.14052 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1851 Subjects: – SubjectFull: Sexual dimorphism Type: general – SubjectFull: Dendritic spines Type: general – SubjectFull: Amygdaloid body Type: general – SubjectFull: Confocal microscopy Type: general – SubjectFull: Rat behavior Type: general – SubjectFull: Neuroplasticity Type: general Titles: – TitleFull: Remodeling of the number and structure of dendritic spines in the medial amygdala: From prepubertal sexual dimorphism to puberty and effect of sexual experience in male rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zancan, Mariana – PersonEntity: Name: NameFull: da Cunha, Rick Shandler R. – PersonEntity: Name: NameFull: Schroeder, Francielle – PersonEntity: Name: NameFull: Xavier, Léder L. – PersonEntity: Name: NameFull: Rasia‐Filho, Alberto A. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 07 Text: Jul2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 48 – Type: issue Value: 2 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
