View in EDS HTML Full Text PDF Full Text

Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress.

Saved in:
Bibliographic Details
Title: Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress.
Authors: Walker, Sophie E., Wood, Tobias C., Cash, Diana, Mesquita, Michel, Williams, Steven C. R., Sandi, Carmen
Source: European Journal of Neuroscience. Jul2018, Vol. 48 Issue 2, p1818-1832. 15p. 1 Diagram, 4 Charts, 4 Graphs.
Subjects: Animal aggression, Effect of stress on animals, Magnetic resonance imaging of the brain, Rat behavior, Laboratory rats
Abstract: Abstract: Exposure to early adversity is implicated in the development of aggressive behaviour later in life in some but not all individuals. The reasons for the variability in response to such experiences are not clear but may relate to pre‐existing individual differences that influence their downstream effects. Applying structural magnetic resonance imaging (MRI) to a rat model of abnormal aggression induced by peripubertal stress, we examined whether individual differences in the development of an aggressive phenotype following stress exposure were underpinned by variation in the structure of aggression‐associated, corticolimbic brain regions. We also assessed whether responsiveness of the hypothalamic–pituitary–adrenal axis to stress was associated with neurobehavioural outcome following adversity. A subset of the rats exposed to peripubertal stress developed an aggressive phenotype, while the remaining rats were affected in other behavioural domains, such as increased anxiety‐like behaviours and reduced sociability. Peripubertal stress led to changes in tissue microstructure within prefrontal cortex, amygdala and hippocampal formation only in those individuals displaying an aggressive phenotype. Attenuated glucocorticoid response to stress during juvenility predicted the subsequent development of an aggressive phenotype in peripubertal stress‐exposed rats. Our study establishes a link between peripubertal stress exposure in rats and structural deviations in brain regions linked to abnormal aggression and points towards low glucocorticoid responsiveness to stress as a potential underlying mechanism. We additionally highlight the importance of considering individual differences in behavioural response to stress when determining neurobiological correlates. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 131115852
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Walker%2C+Sophie+E%2E%22">Walker, Sophie E.</searchLink><br /><searchLink fieldCode="AR" term="%22Wood%2C+Tobias+C%2E%22">Wood, Tobias C.</searchLink><br /><searchLink fieldCode="AR" term="%22Cash%2C+Diana%22">Cash, Diana</searchLink><br /><searchLink fieldCode="AR" term="%22Mesquita%2C+Michel%22">Mesquita, Michel</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Steven+C%2E+R%2E%22">Williams, Steven C. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Sandi%2C+Carmen%22">Sandi, Carmen</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jul2018, Vol. 48 Issue 2, p1818-1832. 15p. 1 Diagram, 4 Charts, 4 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Animal+aggression%22">Animal aggression</searchLink><br /><searchLink fieldCode="DE" term="%22Effect+of+stress+on+animals%22">Effect of stress on animals</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging+of+the+brain%22">Magnetic resonance imaging of the brain</searchLink><br /><searchLink fieldCode="DE" term="%22Rat+behavior%22">Rat behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Exposure to early adversity is implicated in the development of aggressive behaviour later in life in some but not all individuals. The reasons for the variability in response to such experiences are not clear but may relate to pre‐existing individual differences that influence their downstream effects. Applying structural magnetic resonance imaging (MRI) to a rat model of abnormal aggression induced by peripubertal stress, we examined whether individual differences in the development of an aggressive phenotype following stress exposure were underpinned by variation in the structure of aggression‐associated, corticolimbic brain regions. We also assessed whether responsiveness of the hypothalamic–pituitary–adrenal axis to stress was associated with neurobehavioural outcome following adversity. A subset of the rats exposed to peripubertal stress developed an aggressive phenotype, while the remaining rats were affected in other behavioural domains, such as increased anxiety‐like behaviours and reduced sociability. Peripubertal stress led to changes in tissue microstructure within prefrontal cortex, amygdala and hippocampal formation only in those individuals displaying an aggressive phenotype. Attenuated glucocorticoid response to stress during juvenility predicted the subsequent development of an aggressive phenotype in peripubertal stress‐exposed rats. Our study establishes a link between peripubertal stress exposure in rats and structural deviations in brain regions linked to abnormal aggression and points towards low glucocorticoid responsiveness to stress as a potential underlying mechanism. We additionally highlight the importance of considering individual differences in behavioural response to stress when determining neurobiological correlates. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=131115852
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.14061
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 1818
    Subjects:
      – SubjectFull: Animal aggression
        Type: general
      – SubjectFull: Effect of stress on animals
        Type: general
      – SubjectFull: Magnetic resonance imaging of the brain
        Type: general
      – SubjectFull: Rat behavior
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
    Titles:
      – TitleFull: Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Walker, Sophie E.
      – PersonEntity:
          Name:
            NameFull: Wood, Tobias C.
      – PersonEntity:
          Name:
            NameFull: Cash, Diana
      – PersonEntity:
          Name:
            NameFull: Mesquita, Michel
      – PersonEntity:
          Name:
            NameFull: Williams, Steven C. R.
      – PersonEntity:
          Name:
            NameFull: Sandi, Carmen
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 07
              Text: Jul2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 48
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1