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Hemostasis biomarkers in multiple sclerosis.

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Title: Hemostasis biomarkers in multiple sclerosis.
Authors: Bernardi, F., Baroni, M., Ziliotto, N., Jakimovski, D., Bergsland, N., Ramasamy, D. P., Schweser, F., Zivadinov, R., Marchetti, G., Weinstock‐Guttman, B., Zamboni, P., Ramanathan, M.
Source: European Journal of Neurology. Sep2018, Vol. 25 Issue 9, p1169-1176. 8p. 1 Diagram, 3 Charts, 1 Graph.
Subjects: Hemostasis, Biological tags, Multiple sclerosis, Magnetic resonance imaging, Blood coagulation factors, Thrombospondin-1, Plasminogen activator inhibitors
Abstract: Background and purpose: The aim was to investigate the plasma levels of hemostasis components in multiple sclerosis (MS) and their association with clinical and magnetic resonance imaging (MRI) outcomes. Methods: In all, 138 MS patients [85 with relapsing–remitting MS (RR‐MS) and 53 with progressive MS (P‐MS) with a mean age of 54 years; 72.5% female; median Expanded Disability Status Scale 3.5; mean disease duration 21 years] and 42 age‐ and sex‐matched healthy individuals (HI) were studied. All subjects were examined with 3 T MRI and clinical examinations. Plasma levels of hemostasis factors [procoagulant, factor XII (FXII)] and inhibitors [tissue factor pathway inhibitor (TFPI), thrombomodulin, heparin cofactor II, a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and plasminogen activator inhibitor 1 (PAI‐1)] were evaluated by magnetic Luminex assays and enzyme‐linked immunosorbent assay. Associations between hemostasis plasma levels and clinical and MRI outcomes were assessed. Results: Lower ADAMTS13 levels were found in MS patients compared to HI (P = 0.008) and in MS patients presenting with cerebral microbleeds compared to those without (P = 0.034). Higher PAI‐1 levels were found in MS patients compared to HI (P = 0.02). TFPI levels were higher in the P‐MS subgroup compared to RR‐MS patients (P = 0.011) and compared to HI (P = 0.002). No significant associations between hemostasis plasma levels and clinical or MRI outcomes were found. Conclusions: Decreased ADAMTS13, particularly in MS patients with cerebral microbleeds, which deserves further investigation, and increased PAI‐1 and TFPI levels were observed in MS patients, which deserves further investigation. No relationship between hemostasis plasma levels and measures of disease severity was detected. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Hemostasis biomarkers in multiple sclerosis.
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  Data: <searchLink fieldCode="AR" term="%22Bernardi%2C+F%2E%22">Bernardi, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Baroni%2C+M%2E%22">Baroni, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ziliotto%2C+N%2E%22">Ziliotto, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Jakimovski%2C+D%2E%22">Jakimovski, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Bergsland%2C+N%2E%22">Bergsland, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Ramasamy%2C+D%2E+P%2E%22">Ramasamy, D. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Schweser%2C+F%2E%22">Schweser, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Zivadinov%2C+R%2E%22">Zivadinov, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Marchetti%2C+G%2E%22">Marchetti, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Weinstock‐Guttman%2C+B%2E%22">Weinstock‐Guttman, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Zamboni%2C+P%2E%22">Zamboni, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Ramanathan%2C+M%2E%22">Ramanathan, M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Sep2018, Vol. 25 Issue 9, p1169-1176. 8p. 1 Diagram, 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Hemostasis%22">Hemostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+tags%22">Biological tags</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation+factors%22">Blood coagulation factors</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombospondin-1%22">Thrombospondin-1</searchLink><br /><searchLink fieldCode="DE" term="%22Plasminogen+activator+inhibitors%22">Plasminogen activator inhibitors</searchLink>
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  Data: Background and purpose: The aim was to investigate the plasma levels of hemostasis components in multiple sclerosis (MS) and their association with clinical and magnetic resonance imaging (MRI) outcomes. Methods: In all, 138 MS patients [85 with relapsing–remitting MS (RR‐MS) and 53 with progressive MS (P‐MS) with a mean age of 54 years; 72.5% female; median Expanded Disability Status Scale 3.5; mean disease duration 21 years] and 42 age‐ and sex‐matched healthy individuals (HI) were studied. All subjects were examined with 3 T MRI and clinical examinations. Plasma levels of hemostasis factors [procoagulant, factor XII (FXII)] and inhibitors [tissue factor pathway inhibitor (TFPI), thrombomodulin, heparin cofactor II, a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and plasminogen activator inhibitor 1 (PAI‐1)] were evaluated by magnetic Luminex assays and enzyme‐linked immunosorbent assay. Associations between hemostasis plasma levels and clinical and MRI outcomes were assessed. Results: Lower ADAMTS13 levels were found in MS patients compared to HI (P = 0.008) and in MS patients presenting with cerebral microbleeds compared to those without (P = 0.034). Higher PAI‐1 levels were found in MS patients compared to HI (P = 0.02). TFPI levels were higher in the P‐MS subgroup compared to RR‐MS patients (P = 0.011) and compared to HI (P = 0.002). No significant associations between hemostasis plasma levels and clinical or MRI outcomes were found. Conclusions: Decreased ADAMTS13, particularly in MS patients with cerebral microbleeds, which deserves further investigation, and increased PAI‐1 and TFPI levels were observed in MS patients, which deserves further investigation. No relationship between hemostasis plasma levels and measures of disease severity was detected. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ene.13681
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        Text: English
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      – SubjectFull: Hemostasis
        Type: general
      – SubjectFull: Biological tags
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      – SubjectFull: Multiple sclerosis
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