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Rapidly increasing off‐label use of rituximab in multiple sclerosis in Sweden — Outlier or predecessor?

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Title: Rapidly increasing off‐label use of rituximab in multiple sclerosis in Sweden — Outlier or predecessor?
Authors: Berntsson, S. G., Kristoffersson, A., Boström, I., Feresiadou, A., Burman, J., Landtblom, A. M.
Source: Acta Neurologica Scandinavica. Oct2018, Vol. 138 Issue 4, p327-331. 5p.
Subjects: Multiple sclerosis, Rituximab, Drug efficacy, Demyelination, Medical care
Abstract: Objectives: Off‐label use of rituximab to treat MS patients in Sweden is high, and the need for long‐term safety data may not be met. Our objectives were to assess the rate of rituximab prescription in patients with multiple sclerosis in Sweden and, in addition, to evaluate the safety of rituximab in a single centre for patients with multiple sclerosis. Material and Methods: Review of the Swedish MS register was performed to study the number of MS patients treated with rituximab during the last 6 years. Investigation also included a retrospective review of medical files in search for possible side effects/adverse events in all adult patients with MS treated with rituximab at Uppsala University Hospital. Results: Presently, in Sweden the rate of rituximab prescriptions in relation to other annually started of disease‐ modifying drugs in MS is 53.5%. Conclusions: The share of MS patients in Sweden who are treated with rituximab is very high, and also rapidly increasing. Taken into account the off‐label use, cases with adverse medical conditions that could possibly be related to rituximab use should be reported thoroughly. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Rapidly increasing off‐label use of rituximab in multiple sclerosis in Sweden — Outlier or predecessor?
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  Data: <searchLink fieldCode="AR" term="%22Berntsson%2C+S%2E+G%2E%22">Berntsson, S. G.</searchLink><br /><searchLink fieldCode="AR" term="%22Kristoffersson%2C+A%2E%22">Kristoffersson, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Boström%2C+I%2E%22">Boström, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Feresiadou%2C+A%2E%22">Feresiadou, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Burman%2C+J%2E%22">Burman, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Landtblom%2C+A%2E+M%2E%22">Landtblom, A. M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Oct2018, Vol. 138 Issue 4, p327-331. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Rituximab%22">Rituximab</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Demyelination%22">Demyelination</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care%22">Medical care</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: Off‐label use of rituximab to treat MS patients in Sweden is high, and the need for long‐term safety data may not be met. Our objectives were to assess the rate of rituximab prescription in patients with multiple sclerosis in Sweden and, in addition, to evaluate the safety of rituximab in a single centre for patients with multiple sclerosis. Material and Methods: Review of the Swedish MS register was performed to study the number of MS patients treated with rituximab during the last 6 years. Investigation also included a retrospective review of medical files in search for possible side effects/adverse events in all adult patients with MS treated with rituximab at Uppsala University Hospital. Results: Presently, in Sweden the rate of rituximab prescriptions in relation to other annually started of disease‐ modifying drugs in MS is 53.5%. Conclusions: The share of MS patients in Sweden who are treated with rituximab is very high, and also rapidly increasing. Taken into account the off‐label use, cases with adverse medical conditions that could possibly be related to rituximab use should be reported thoroughly. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ane.12963
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      – Code: eng
        Text: English
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        Type: general
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      – SubjectFull: Drug efficacy
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      – SubjectFull: Demyelination
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      – SubjectFull: Medical care
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              Text: Oct2018
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