Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease.
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| Title: | Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. |
|---|---|
| Authors: | Abautret-Daly, Áine, Dempsey, Elaine, Parra-Blanco, Adolfo, Medina, Carlos, Harkin, Andrew |
| Source: | Acta Neuropsychiatrica. Oct2018, Vol. 30 Issue 5, p275-296. 22p. |
| Subjects: | Comorbidity, Inflammatory bowel diseases, Quality of life, Mental depression, Colitis, Anxiety |
| Abstract: | Introduction: Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD. Results: The likely mechanisms underlying the association are discussed with particular reference to communication between the gut and brain. The close bidirectional relationship known as the gut–brain axis includes neural, hormonal and immune communication links. Evidence is provided for a number of interacting factors including activation of the inflammatory response system in the brain, the hypothalamic–pituitary–adrenal axis, and brain areas implicated in altered behaviours, changes in blood brain barrier integrity, and an emerging role for gut microbiota and response to probiotics in IBD. Discussion: The impact of psychological stress in models of IBD remains somewhat conflicted, however, it is weighted in favour of stress or early stressful life events as risk factors in the development of IBD, stress-induced exacerbation of inflammation and relapse. Conclusion: It is recommended that patients with IBD be screened for psychological disturbance and treated accordingly as intervention can improve quality of life and may reduce relapse rates. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 131998033 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Abautret-Daly%2C+Áine%22">Abautret-Daly, Áine</searchLink><br /><searchLink fieldCode="AR" term="%22Dempsey%2C+Elaine%22">Dempsey, Elaine</searchLink><br /><searchLink fieldCode="AR" term="%22Parra-Blanco%2C+Adolfo%22">Parra-Blanco, Adolfo</searchLink><br /><searchLink fieldCode="AR" term="%22Medina%2C+Carlos%22">Medina, Carlos</searchLink><br /><searchLink fieldCode="AR" term="%22Harkin%2C+Andrew%22">Harkin, Andrew</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neuropsychiatrica%22">Acta Neuropsychiatrica</searchLink>. Oct2018, Vol. 30 Issue 5, p275-296. 22p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+bowel+diseases%22">Inflammatory bowel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Colitis%22">Colitis</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD. Results: The likely mechanisms underlying the association are discussed with particular reference to communication between the gut and brain. The close bidirectional relationship known as the gut–brain axis includes neural, hormonal and immune communication links. Evidence is provided for a number of interacting factors including activation of the inflammatory response system in the brain, the hypothalamic–pituitary–adrenal axis, and brain areas implicated in altered behaviours, changes in blood brain barrier integrity, and an emerging role for gut microbiota and response to probiotics in IBD. Discussion: The impact of psychological stress in models of IBD remains somewhat conflicted, however, it is weighted in favour of stress or early stressful life events as risk factors in the development of IBD, stress-induced exacerbation of inflammation and relapse. Conclusion: It is recommended that patients with IBD be screened for psychological disturbance and treated accordingly as intervention can improve quality of life and may reduce relapse rates. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=131998033 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/neu.2017.3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 22 StartPage: 275 Subjects: – SubjectFull: Comorbidity Type: general – SubjectFull: Inflammatory bowel diseases Type: general – SubjectFull: Quality of life Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Colitis Type: general – SubjectFull: Anxiety Type: general Titles: – TitleFull: Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Abautret-Daly, Áine – PersonEntity: Name: NameFull: Dempsey, Elaine – PersonEntity: Name: NameFull: Parra-Blanco, Adolfo – PersonEntity: Name: NameFull: Medina, Carlos – PersonEntity: Name: NameFull: Harkin, Andrew IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 09242708 Numbering: – Type: volume Value: 30 – Type: issue Value: 5 Titles: – TitleFull: Acta Neuropsychiatrica Type: main |
| ResultId | 1 |
