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Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.

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Title: Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.
Authors: Hongbing Wang, Ferguson, Gregory D., Pineda, Victor V., Cundiff, Paige E., Storm, Daniel R.
Source: Nature Neuroscience. Jun2004, Vol. 7 Issue 6, p635-642. 8p.
Subjects: Adenylate cyclase, Animal models in research, Recognition (Psychology), Memory, Hippocampus (Brain), Protein kinases, Mitogens
Abstract: Cyclic AMP is a positive regulator of synaptic plasticity and is required for several forms of hippocampus-dependent memory including recognition memory. The type I adenylyl cyclase, Adcy1 (also known as AC1), is crucial in memory formation because it couples Ca2+ to cyclic AMP increases in the hippocampus. Because Adcy1 is neurospecific, it is a potential pharmacological target for increasing cAMP specifically in the brain and for improving memory. We have generated transgenic mice that overexpress Adcy1 in the forebrain using the Camk2a (also known as a-CaMKII) promoter. These mice showed elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory. The increase in recognition memory and lower rates of contextual memory extinction may be due to enhanced extracellular signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling, which is elevated in mice that overexpress Adcy1. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.
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  Data: <searchLink fieldCode="AR" term="%22Hongbing+Wang%22">Hongbing Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Ferguson%2C+Gregory+D%2E%22">Ferguson, Gregory D.</searchLink><br /><searchLink fieldCode="AR" term="%22Pineda%2C+Victor+V%2E%22">Pineda, Victor V.</searchLink><br /><searchLink fieldCode="AR" term="%22Cundiff%2C+Paige+E%2E%22">Cundiff, Paige E.</searchLink><br /><searchLink fieldCode="AR" term="%22Storm%2C+Daniel+R%2E%22">Storm, Daniel R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Jun2004, Vol. 7 Issue 6, p635-642. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Adenylate+cyclase%22">Adenylate cyclase</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink><br /><searchLink fieldCode="DE" term="%22Recognition+%28Psychology%29%22">Recognition (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Mitogens%22">Mitogens</searchLink>
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  Data: Cyclic AMP is a positive regulator of synaptic plasticity and is required for several forms of hippocampus-dependent memory including recognition memory. The type I adenylyl cyclase, Adcy1 (also known as AC1), is crucial in memory formation because it couples Ca2+ to cyclic AMP increases in the hippocampus. Because Adcy1 is neurospecific, it is a potential pharmacological target for increasing cAMP specifically in the brain and for improving memory. We have generated transgenic mice that overexpress Adcy1 in the forebrain using the Camk2a (also known as a-CaMKII) promoter. These mice showed elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory. The increase in recognition memory and lower rates of contextual memory extinction may be due to enhanced extracellular signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling, which is elevated in mice that overexpress Adcy1. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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