Complication Burden Index—A tool for comprehensive evaluation of the effect of complications on functional outcome after status epilepticus.
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| Title: | Complication Burden Index—A tool for comprehensive evaluation of the effect of complications on functional outcome after status epilepticus. |
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| Authors: | Kämppi, Leena, Ritvanen, Jaakko, Strbian, Daniel, Mustonen, Harri, Soinila, Seppo |
| Source: | Epilepsia (Series 4). Oct2018 Supplement S2, Vol. 59 Issue 2, p176-181. 6p. |
| Subjects: | Status epilepticus, Musculoskeletal system, Hyperglycemia, Intubation |
| Abstract: | Summary: Systemic complications are common in status epilepticus. We have no tools to evaluate total burden of complications and its effect on the outcome of status epilepticus. For Complication Burden Index (CBI) a patient is assessed for 13 complication categories: respiratory, cardiovascular, nervous, renal, hepatic, coagulation, gastrointestinal and musculoskeletal systems, electrolyte/acid‐base balance, infection, hypo‐/hyperglycemia, skin/allergic reactions, and mental condition. Maximum CBI is 13. CBI was internally validated in a retrospective cohort of 70 consecutive adult patients with generalized convulsive status epilepticus (GCSE) treated in a tertiary hospital over a period of 2 years. Functional outcome at discharge was defined Poor for Glascow Outcome Scale (GOS) 1‐3 or worse‐than‐baseline condition and Good for GOS >3 or return to baseline condition. Relative risks (RRs) and receiver‐operating characteristic (ROC) ‐curves were calculated to obtain optimal cutoff. Functional outcome was poor in 40% and worse‐than‐baseline in 59%. In‐hospital mortality was 7%. Average CBI was 3.8 (range 0‐10, median 3). Cutoff value predicting poor functional outcome was a CBI >3 (GOS 1‐3 RR 1.84, P = .045, 95% confidence interval [CI 1.01‐3.33; ROC‐AUC [area under the curve] 0.687, P = .008, sensitivity 64%, specificity 61%; worse‐than‐baseline condition RR 1.52, P = .04, 95% CI 1.02‐2.26; ROC‐AUC 0.662, P = .022, sensitivity 56%, specificity 69%). CBI with cutoff >3 and as a continuous variable was associated with GOS1‐3 (P = .046, P = .002) and with worse‐than‐baseline condition (P = .041, P = .004). CBI is a novel tool for comprehensive assessment of status epilepticus complications predicting poor/worse‐than‐baseline functional outcome with cutoff >3. [ABSTRACT FROM AUTHOR] |
| Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 132162146 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Complication Burden Index—A tool for comprehensive evaluation of the effect of complications on functional outcome after status epilepticus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kämppi%2C+Leena%22">Kämppi, Leena</searchLink><br /><searchLink fieldCode="AR" term="%22Ritvanen%2C+Jaakko%22">Ritvanen, Jaakko</searchLink><br /><searchLink fieldCode="AR" term="%22Strbian%2C+Daniel%22">Strbian, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Mustonen%2C+Harri%22">Mustonen, Harri</searchLink><br /><searchLink fieldCode="AR" term="%22Soinila%2C+Seppo%22">Soinila, Seppo</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Oct2018 Supplement S2, Vol. 59 Issue 2, p176-181. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Status+epilepticus%22">Status epilepticus</searchLink><br /><searchLink fieldCode="DE" term="%22Musculoskeletal+system%22">Musculoskeletal system</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperglycemia%22">Hyperglycemia</searchLink><br /><searchLink fieldCode="DE" term="%22Intubation%22">Intubation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Summary: Systemic complications are common in status epilepticus. We have no tools to evaluate total burden of complications and its effect on the outcome of status epilepticus. For Complication Burden Index (CBI) a patient is assessed for 13 complication categories: respiratory, cardiovascular, nervous, renal, hepatic, coagulation, gastrointestinal and musculoskeletal systems, electrolyte/acid‐base balance, infection, hypo‐/hyperglycemia, skin/allergic reactions, and mental condition. Maximum CBI is 13. CBI was internally validated in a retrospective cohort of 70 consecutive adult patients with generalized convulsive status epilepticus (GCSE) treated in a tertiary hospital over a period of 2 years. Functional outcome at discharge was defined Poor for Glascow Outcome Scale (GOS) 1‐3 or worse‐than‐baseline condition and Good for GOS >3 or return to baseline condition. Relative risks (RRs) and receiver‐operating characteristic (ROC) ‐curves were calculated to obtain optimal cutoff. Functional outcome was poor in 40% and worse‐than‐baseline in 59%. In‐hospital mortality was 7%. Average CBI was 3.8 (range 0‐10, median 3). Cutoff value predicting poor functional outcome was a CBI >3 (GOS 1‐3 RR 1.84, P = .045, 95% confidence interval [CI 1.01‐3.33; ROC‐AUC [area under the curve] 0.687, P = .008, sensitivity 64%, specificity 61%; worse‐than‐baseline condition RR 1.52, P = .04, 95% CI 1.02‐2.26; ROC‐AUC 0.662, P = .022, sensitivity 56%, specificity 69%). CBI with cutoff >3 and as a continuous variable was associated with GOS1‐3 (P = .046, P = .002) and with worse‐than‐baseline condition (P = .041, P = .004). CBI is a novel tool for comprehensive assessment of status epilepticus complications predicting poor/worse‐than‐baseline functional outcome with cutoff >3. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/epi.14491 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 176 Subjects: – SubjectFull: Status epilepticus Type: general – SubjectFull: Musculoskeletal system Type: general – SubjectFull: Hyperglycemia Type: general – SubjectFull: Intubation Type: general Titles: – TitleFull: Complication Burden Index—A tool for comprehensive evaluation of the effect of complications on functional outcome after status epilepticus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kämppi, Leena – PersonEntity: Name: NameFull: Ritvanen, Jaakko – PersonEntity: Name: NameFull: Strbian, Daniel – PersonEntity: Name: NameFull: Mustonen, Harri – PersonEntity: Name: NameFull: Soinila, Seppo IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 10 Text: Oct2018 Supplement S2 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 00139580 Numbering: – Type: volume Value: 59 – Type: issue Value: 2 Titles: – TitleFull: Epilepsia (Series 4) Type: main |
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