View in EDS HTML Full Text PDF Full Text

Modelling the impact of a national scale‐up of interventions on hepatitis C virus transmission among people who inject drugs in Scotland.

Saved in:
Bibliographic Details
Title: Modelling the impact of a national scale‐up of interventions on hepatitis C virus transmission among people who inject drugs in Scotland.
Authors: Fraser, Hannah, Mukandavire, Christinah, Martin, Natasha K., Goldberg, David, Palmateer, Norah, Munro, Alison, Taylor, Avril, Hickman, Matthew, Hutchinson, Sharon, Vickerman, Peter
Source: Addiction. Nov2018, Vol. 113 Issue 11, p2118-2131. 14p. 2 Charts, 3 Graphs.
Subjects: Intravenous drug abusers, Hepatitis C transmission, Hepatitis C prevention, Methadone treatment programs, Needle exchange programs, Risk-taking behavior, Government aid, Treatment effectiveness
Geographic Terms: Scotland
Abstract: Background and Aims: To reduce hepatitis C virus (HCV) transmission among people who inject drugs (PWID), Scottish Government‐funded national strategies, launched in 2008, promoted scaling‐up opioid substitution therapy (OST) and needle and syringe provision (NSP), with some increases in HCV treatment. We test whether observed decreases in HCV incidence post‐2008 can be attributed to this intervention scale‐up. Design A dynamic HCV transmission model among PWID incorporating intervention scale‐up and observed decreases in behavioural risk, calibrated to Scottish HCV prevalence and incidence data for 2008/09. Setting: Scotland, UK. Participants: PWID. Measurements Model projections from 2008 to 2015 were compared with data to test whether they were consistent with observed decreases in HCV incidence among PWID while incorporating the observed intervention scale‐up, and to determine the impact of scaling‐up interventions on incidence. Findings Without fitting to epidemiological data post‐2008/09, the model incorporating observed intervention scale‐up agreed with observed decreases in HCV incidence among PWID between 2008 and 2015, suggesting that HCV incidence decreased by 61.3% [95% credibility interval (CrI) = 45.1–75.3%] from 14.2/100 person‐years (py) (9.0–20.7) to 5.5/100 py (2.9–9.2). On average, each model fit lay within 84% (10.1/12) of the confidence bounds for the 12 incidence data points against which the model was compared. We estimate that scale‐up of interventions (OST + NSP + HCV treatment) and decreases in high‐risk behaviour from 2008 to 2015 resulted in a 33.9% (23.8–44.6%) decrease in incidence, with the remainder [27.4% (17.6–37.0%)] explained by historical changes in OST + NSP coverage and risk pre‐2008. Projections suggest that scaling‐up of all interventions post‐2008 averted 1492 (657–2646) infections over 7 years, with 1016 (308–1996), 404 (150–836) and 72 (27–137) due to scale‐up of OST + NSP, decreases in high‐risk behaviour and HCV treatment, respectively. Conclusions: Most of the decline in hepatitis C virus (HCV) incidence in Scotland between 2008 and 2015 appears to be attributable to intervention scale‐up (opioid substitution therapy and needle and syringe provision) due to government strategies on HCV and drugs. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 132211577
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Modelling the impact of a national scale‐up of interventions on hepatitis C virus transmission among people who inject drugs in Scotland.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Fraser%2C+Hannah%22">Fraser, Hannah</searchLink><br /><searchLink fieldCode="AR" term="%22Mukandavire%2C+Christinah%22">Mukandavire, Christinah</searchLink><br /><searchLink fieldCode="AR" term="%22Martin%2C+Natasha+K%2E%22">Martin, Natasha K.</searchLink><br /><searchLink fieldCode="AR" term="%22Goldberg%2C+David%22">Goldberg, David</searchLink><br /><searchLink fieldCode="AR" term="%22Palmateer%2C+Norah%22">Palmateer, Norah</searchLink><br /><searchLink fieldCode="AR" term="%22Munro%2C+Alison%22">Munro, Alison</searchLink><br /><searchLink fieldCode="AR" term="%22Taylor%2C+Avril%22">Taylor, Avril</searchLink><br /><searchLink fieldCode="AR" term="%22Hickman%2C+Matthew%22">Hickman, Matthew</searchLink><br /><searchLink fieldCode="AR" term="%22Hutchinson%2C+Sharon%22">Hutchinson, Sharon</searchLink><br /><searchLink fieldCode="AR" term="%22Vickerman%2C+Peter%22">Vickerman, Peter</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Nov2018, Vol. 113 Issue 11, p2118-2131. 14p. 2 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Intravenous+drug+abusers%22">Intravenous drug abusers</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+C+transmission%22">Hepatitis C transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+C+prevention%22">Hepatitis C prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Methadone+treatment+programs%22">Methadone treatment programs</searchLink><br /><searchLink fieldCode="DE" term="%22Needle+exchange+programs%22">Needle exchange programs</searchLink><br /><searchLink fieldCode="DE" term="%22Risk-taking+behavior%22">Risk-taking behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Government+aid%22">Government aid</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Scotland%22">Scotland</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and Aims: To reduce hepatitis C virus (HCV) transmission among people who inject drugs (PWID), Scottish Government‐funded national strategies, launched in 2008, promoted scaling‐up opioid substitution therapy (OST) and needle and syringe provision (NSP), with some increases in HCV treatment. We test whether observed decreases in HCV incidence post‐2008 can be attributed to this intervention scale‐up. Design A dynamic HCV transmission model among PWID incorporating intervention scale‐up and observed decreases in behavioural risk, calibrated to Scottish HCV prevalence and incidence data for 2008/09. Setting: Scotland, UK. Participants: PWID. Measurements Model projections from 2008 to 2015 were compared with data to test whether they were consistent with observed decreases in HCV incidence among PWID while incorporating the observed intervention scale‐up, and to determine the impact of scaling‐up interventions on incidence. Findings Without fitting to epidemiological data post‐2008/09, the model incorporating observed intervention scale‐up agreed with observed decreases in HCV incidence among PWID between 2008 and 2015, suggesting that HCV incidence decreased by 61.3% [95% credibility interval (CrI) = 45.1–75.3%] from 14.2/100 person‐years (py) (9.0–20.7) to 5.5/100 py (2.9–9.2). On average, each model fit lay within 84% (10.1/12) of the confidence bounds for the 12 incidence data points against which the model was compared. We estimate that scale‐up of interventions (OST + NSP + HCV treatment) and decreases in high‐risk behaviour from 2008 to 2015 resulted in a 33.9% (23.8–44.6%) decrease in incidence, with the remainder [27.4% (17.6–37.0%)] explained by historical changes in OST + NSP coverage and risk pre‐2008. Projections suggest that scaling‐up of all interventions post‐2008 averted 1492 (657–2646) infections over 7 years, with 1016 (308–1996), 404 (150–836) and 72 (27–137) due to scale‐up of OST + NSP, decreases in high‐risk behaviour and HCV treatment, respectively. Conclusions: Most of the decline in hepatitis C virus (HCV) incidence in Scotland between 2008 and 2015 appears to be attributable to intervention scale‐up (opioid substitution therapy and needle and syringe provision) due to government strategies on HCV and drugs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=132211577
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/add.14267
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 2118
    Subjects:
      – SubjectFull: Intravenous drug abusers
        Type: general
      – SubjectFull: Hepatitis C transmission
        Type: general
      – SubjectFull: Hepatitis C prevention
        Type: general
      – SubjectFull: Methadone treatment programs
        Type: general
      – SubjectFull: Needle exchange programs
        Type: general
      – SubjectFull: Risk-taking behavior
        Type: general
      – SubjectFull: Government aid
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Scotland
        Type: general
    Titles:
      – TitleFull: Modelling the impact of a national scale‐up of interventions on hepatitis C virus transmission among people who inject drugs in Scotland.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fraser, Hannah
      – PersonEntity:
          Name:
            NameFull: Mukandavire, Christinah
      – PersonEntity:
          Name:
            NameFull: Martin, Natasha K.
      – PersonEntity:
          Name:
            NameFull: Goldberg, David
      – PersonEntity:
          Name:
            NameFull: Palmateer, Norah
      – PersonEntity:
          Name:
            NameFull: Munro, Alison
      – PersonEntity:
          Name:
            NameFull: Taylor, Avril
      – PersonEntity:
          Name:
            NameFull: Hickman, Matthew
      – PersonEntity:
          Name:
            NameFull: Hutchinson, Sharon
      – PersonEntity:
          Name:
            NameFull: Vickerman, Peter
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 09652140
          Numbering:
            – Type: volume
              Value: 113
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Addiction
              Type: main
ResultId 1