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Effects of Repeated Treatment with Midazolam in SHR and SLA16 Rat Strains in the Triple Test.

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Title: Effects of Repeated Treatment with Midazolam in SHR and SLA16 Rat Strains in the Triple Test.
Authors: Acuña, Lucía Raily, Marchette, Renata Cristina Nunes, Granzotto, Natalli, Dias, Paula Gomes, Corvino, Maria Elisa, Mazur, Fernando Gabriel, Corrêa, Fernanda Junques, Izídio, Geison Souza
Source: Behavior Genetics. Nov2018, Vol. 48 Issue 6, p440-450. 11p.
Subjects: Midazolam, Hypertension, Tranquilizing drugs, Rat behavior, Drug tolerance
Abstract: We exposed male and female rats of SHR (Spontaneously Hypertensive Rats) and SLA16 (SHR.LEW-Anxrr16) strains, in a non-drugged state, for five consecutive days to the Triple Test (experiment 1); or after repeated treatment with midazolam (MDZ), for four consecutive days. The fifth day was performed without treatment (experiment 2). The first experiment showed that males did not avoid and females increased the exploration of the open arms over the days. In experiment 2, SLA16 from both sexes approached more the open arms than SHR rats. The MDZ anxiolytic-like effect was sustained in both strains and sexes over the days. On the fifth day, SLA16 still approached more the open arms than SHR rats. Data suggest an absence of repeated-trial tolerance to MDZ anxiolytic-like effects. Testing the SHR and SLA16 strains, especially females, could be necessary for the future search for the genes and molecular pathways underlying anxiety/emotionality. [ABSTRACT FROM AUTHOR]
Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of Repeated Treatment with Midazolam in SHR and SLA16 Rat Strains in the Triple Test.
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  Data: <searchLink fieldCode="AR" term="%22Acuña%2C+Lucía+Raily%22">Acuña, Lucía Raily</searchLink><br /><searchLink fieldCode="AR" term="%22Marchette%2C+Renata+Cristina+Nunes%22">Marchette, Renata Cristina Nunes</searchLink><br /><searchLink fieldCode="AR" term="%22Granzotto%2C+Natalli%22">Granzotto, Natalli</searchLink><br /><searchLink fieldCode="AR" term="%22Dias%2C+Paula+Gomes%22">Dias, Paula Gomes</searchLink><br /><searchLink fieldCode="AR" term="%22Corvino%2C+Maria+Elisa%22">Corvino, Maria Elisa</searchLink><br /><searchLink fieldCode="AR" term="%22Mazur%2C+Fernando+Gabriel%22">Mazur, Fernando Gabriel</searchLink><br /><searchLink fieldCode="AR" term="%22Corrêa%2C+Fernanda+Junques%22">Corrêa, Fernanda Junques</searchLink><br /><searchLink fieldCode="AR" term="%22Izídio%2C+Geison+Souza%22">Izídio, Geison Souza</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Midazolam%22">Midazolam</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Tranquilizing+drugs%22">Tranquilizing drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Rat+behavior%22">Rat behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+tolerance%22">Drug tolerance</searchLink>
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  Data: We exposed male and female rats of SHR (Spontaneously Hypertensive Rats) and SLA16 (SHR.LEW-Anxrr16) strains, in a non-drugged state, for five consecutive days to the Triple Test (experiment 1); or after repeated treatment with midazolam (MDZ), for four consecutive days. The fifth day was performed without treatment (experiment 2). The first experiment showed that males did not avoid and females increased the exploration of the open arms over the days. In experiment 2, SLA16 from both sexes approached more the open arms than SHR rats. The MDZ anxiolytic-like effect was sustained in both strains and sexes over the days. On the fifth day, SLA16 still approached more the open arms than SHR rats. Data suggest an absence of repeated-trial tolerance to MDZ anxiolytic-like effects. Testing the SHR and SLA16 strains, especially females, could be necessary for the future search for the genes and molecular pathways underlying anxiety/emotionality. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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