Effects of Repeated Treatment with Midazolam in SHR and SLA16 Rat Strains in the Triple Test.

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Bibliographic Details
Title:	Effects of Repeated Treatment with Midazolam in SHR and SLA16 Rat Strains in the Triple Test.
Authors:	Acuña, Lucía Raily, Marchette, Renata Cristina Nunes, Granzotto, Natalli, Dias, Paula Gomes, Corvino, Maria Elisa, Mazur, Fernando Gabriel, Corrêa, Fernanda Junques, Izídio, Geison Souza
Source:	Behavior Genetics. Nov2018, Vol. 48 Issue 6, p440-450. 11p.
Subjects:	Midazolam, Hypertension, Tranquilizing drugs, Rat behavior, Drug tolerance
Abstract:	We exposed male and female rats of SHR (Spontaneously Hypertensive Rats) and SLA16 (SHR.LEW-Anxrr16) strains, in a non-drugged state, for five consecutive days to the Triple Test (experiment 1); or after repeated treatment with midazolam (MDZ), for four consecutive days. The fifth day was performed without treatment (experiment 2). The first experiment showed that males did not avoid and females increased the exploration of the open arms over the days. In experiment 2, SLA16 from both sexes approached more the open arms than SHR rats. The MDZ anxiolytic-like effect was sustained in both strains and sexes over the days. On the fifth day, SLA16 still approached more the open arms than SHR rats. Data suggest an absence of repeated-trial tolerance to MDZ anxiolytic-like effects. Testing the SHR and SLA16 strains, especially females, could be necessary for the future search for the genes and molecular pathways underlying anxiety/emotionality. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	We exposed male and female rats of SHR (Spontaneously Hypertensive Rats) and SLA16 (SHR.LEW-Anxrr16) strains, in a non-drugged state, for five consecutive days to the Triple Test (experiment 1); or after repeated treatment with midazolam (MDZ), for four consecutive days. The fifth day was performed without treatment (experiment 2). The first experiment showed that males did not avoid and females increased the exploration of the open arms over the days. In experiment 2, SLA16 from both sexes approached more the open arms than SHR rats. The MDZ anxiolytic-like effect was sustained in both strains and sexes over the days. On the fifth day, SLA16 still approached more the open arms than SHR rats. Data suggest an absence of repeated-trial tolerance to MDZ anxiolytic-like effects. Testing the SHR and SLA16 strains, especially females, could be necessary for the future search for the genes and molecular pathways underlying anxiety/emotionality. [ABSTRACT FROM AUTHOR]
ISSN:	00018244
DOI:	10.1007/s10519-018-9922-2