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Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder.

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Title: Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder.
Authors: Chen, Lyon W., Sun, Delin, Davis, Sarah L., Haswell, Courtney C., Dennis, Emily L., Swanson, Chelsea A., Whelan, Christopher D., Gutman, Boris, Jahanshad, Neda, Iglesias, Juan Eugenio, Thompson, Paul, Wagner, H. Ryan, Saemann, Philipp, LaBar, Kevin S., Morey, Rajendra A., Mid-Atlantic MIRECC Workgroup
Source: Depression & Anxiety (1091-4269). Nov2018, Vol. 35 Issue 11, p1018-1029. 12p. 3 Color Photographs, 4 Charts, 1 Graph.
Subjects: Post-traumatic stress disorder, Hippocampus (Brain), Amygdaloid body, Emotional trauma, Mental depression, Anxiety disorders, Mental health of veterans, Psychological stress
Abstract: Background: Smaller hippocampal volume in patients with posttraumatic stress disorder (PTSD) represents the most consistently reported structural alteration in the brain. Subfields of the hippocampus play distinct roles in encoding and processing of memories, which are disrupted in PTSD. We examined PTSD-associated alterations in 12 hippocampal subfields in relation to global hippocampal shape, and clinical features.Methods: Case-control cross-sectional studies of U.S. military veterans (n = 282) from the Iraq and Afghanistan era were grouped into PTSD (n = 142) and trauma-exposed controls (n = 140). Participants underwent clinical evaluation for PTSD and associated clinical parameters followed by MRI at 3 T. Segmentation with FreeSurfer v6.0 produced hippocampal subfield volumes for the left and right CA1, CA3, CA4, DG, fimbria, fissure, hippocampus-amygdala transition area, molecular layer, parasubiculum, presubiculum, subiculum, and tail, as well as hippocampal meshes. Covariates included age, gender, trauma exposure, alcohol use, depressive symptoms, antidepressant medication use, total hippocampal volume, and MRI scanner model.Results: Significantly lower subfield volumes were associated with PTSD in left CA1 (P = 0.01; d = 0.21; uncorrected), CA3 (P = 0.04; d = 0.08; uncorrected), and right CA3 (P = 0.02; d = 0.07; uncorrected) only if ipsilateral whole hippocampal volume was included as a covariate. A trend level association of L-CA1 with PTSD (F4, 221  = 3.32, P = 0.07) is present and the other subfield findings are nonsignificant if ipsilateral whole hippocampal volume is not included as a covariate. PTSD-associated differences in global hippocampal shape were nonsignificant.Conclusions: The present finding of smaller hippocampal CA1 in PTSD is consistent with model systems in rodents that exhibit increased anxiety-like behavior from repeated exposure to acute stress. Behavioral correlations with hippocampal subfield volume differences in PTSD will elucidate their relevance to PTSD, particularly behaviors of associative fear learning, extinction training, and formation of false memories. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Lyon+W%2E%22">Chen, Lyon W.</searchLink><br /><searchLink fieldCode="AR" term="%22Sun%2C+Delin%22">Sun, Delin</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+Sarah+L%2E%22">Davis, Sarah L.</searchLink><br /><searchLink fieldCode="AR" term="%22Haswell%2C+Courtney+C%2E%22">Haswell, Courtney C.</searchLink><br /><searchLink fieldCode="AR" term="%22Dennis%2C+Emily+L%2E%22">Dennis, Emily L.</searchLink><br /><searchLink fieldCode="AR" term="%22Swanson%2C+Chelsea+A%2E%22">Swanson, Chelsea A.</searchLink><br /><searchLink fieldCode="AR" term="%22Whelan%2C+Christopher+D%2E%22">Whelan, Christopher D.</searchLink><br /><searchLink fieldCode="AR" term="%22Gutman%2C+Boris%22">Gutman, Boris</searchLink><br /><searchLink fieldCode="AR" term="%22Jahanshad%2C+Neda%22">Jahanshad, Neda</searchLink><br /><searchLink fieldCode="AR" term="%22Iglesias%2C+Juan+Eugenio%22">Iglesias, Juan Eugenio</searchLink><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Paul%22">Thompson, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Wagner%2C+H%2E+Ryan%22">Wagner, H. Ryan</searchLink><br /><searchLink fieldCode="AR" term="%22Saemann%2C+Philipp%22">Saemann, Philipp</searchLink><br /><searchLink fieldCode="AR" term="%22LaBar%2C+Kevin+S%2E%22">LaBar, Kevin S.</searchLink><br /><searchLink fieldCode="AR" term="%22Morey%2C+Rajendra+A%2E%22">Morey, Rajendra A.</searchLink><br /><searchLink fieldCode="AR" term="%22Mid-Atlantic+MIRECC+Workgroup%22">Mid-Atlantic MIRECC Workgroup</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Nov2018, Vol. 35 Issue 11, p1018-1029. 12p. 3 Color Photographs, 4 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Emotional+trauma%22">Emotional trauma</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+of+veterans%22">Mental health of veterans</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>Smaller hippocampal volume in patients with posttraumatic stress disorder (PTSD) represents the most consistently reported structural alteration in the brain. Subfields of the hippocampus play distinct roles in encoding and processing of memories, which are disrupted in PTSD. We examined PTSD-associated alterations in 12 hippocampal subfields in relation to global hippocampal shape, and clinical features.<bold>Methods: </bold>Case-control cross-sectional studies of U.S. military veterans (n = 282) from the Iraq and Afghanistan era were grouped into PTSD (n = 142) and trauma-exposed controls (n = 140). Participants underwent clinical evaluation for PTSD and associated clinical parameters followed by MRI at 3 T. Segmentation with FreeSurfer v6.0 produced hippocampal subfield volumes for the left and right CA1, CA3, CA4, DG, fimbria, fissure, hippocampus-amygdala transition area, molecular layer, parasubiculum, presubiculum, subiculum, and tail, as well as hippocampal meshes. Covariates included age, gender, trauma exposure, alcohol use, depressive symptoms, antidepressant medication use, total hippocampal volume, and MRI scanner model.<bold>Results: </bold>Significantly lower subfield volumes were associated with PTSD in left CA1 (P = 0.01; d = 0.21; uncorrected), CA3 (P = 0.04; d = 0.08; uncorrected), and right CA3 (P = 0.02; d = 0.07; uncorrected) only if ipsilateral whole hippocampal volume was included as a covariate. A trend level association of L-CA1 with PTSD (F4, 221  = 3.32, P = 0.07) is present and the other subfield findings are nonsignificant if ipsilateral whole hippocampal volume is not included as a covariate. PTSD-associated differences in global hippocampal shape were nonsignificant.<bold>Conclusions: </bold>The present finding of smaller hippocampal CA1 in PTSD is consistent with model systems in rodents that exhibit increased anxiety-like behavior from repeated exposure to acute stress. Behavioral correlations with hippocampal subfield volume differences in PTSD will elucidate their relevance to PTSD, particularly behaviors of associative fear learning, extinction training, and formation of false memories. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/da.22833
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        Text: English
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      – SubjectFull: Post-traumatic stress disorder
        Type: general
      – SubjectFull: Hippocampus (Brain)
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      – SubjectFull: Amygdaloid body
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      – SubjectFull: Emotional trauma
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      – SubjectFull: Mental depression
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      – SubjectFull: Anxiety disorders
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      – SubjectFull: Mental health of veterans
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      – SubjectFull: Psychological stress
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              Text: Nov2018
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