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Different cutoffs of the reflux finding score for diagnosing laryngopharyngeal reflux disease should be used for different genders.

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Title: Different cutoffs of the reflux finding score for diagnosing laryngopharyngeal reflux disease should be used for different genders.
Authors: Cheng-Kai Gao, Yan-Fei Li, Lu Wang, Xiao-Yan Han, Ting Wu, Fang-Fang Zeng, Xiang-Ping Li
Source: Acta Oto-Laryngologica (Supplement). Sep2018, Vol. 138 Issue 9, p848-854. 7p. 5 Charts, 2 Graphs.
Subjects: Gastroesophageal reflux diagnosis, Fiber optics, Laryngoscopy, Reliability (Personality trait), Sex distribution, Symptoms, Receiver operating characteristic curves, Intraclass correlation
Abstract: Objectives: To assess the differences in Reflux Finding Score (RFS) between the genders and determine the suitable RFS threshold for diagnosing laryngopharyngeal reflux disease (LPRD) in each gender. Methods: Asymptomatic volunteers and patients with LPRD, confirmed with an oropharyngeal Dx-pH monitoring system, were included. All study subjects underwent transnasal flexible fiber-optic video laryngoscopy. Reliability was assessed with intra-class correlation coefficients (ICCs) and Bland-Altman plots. The RFS cutoffs for determining the presence and absence of LPRD between the two genders were examined by receiver operating characteristic (ROC) analysis. Results: One hundred seven asymptomatic volunteers and fifty-five LPRD patients were recruited. The mean RFS for LPRD subjects (9.4±3.2) was significantly higher than that for control subjects (7.1 ±2.6; p<0.001). The mean RFS for asymptomatic females (6.1 ±2.7) was significantly lower than that for males (7.7 ±2.5; p < 0.001). The mean RFS for female subjects with LPRD (7.8 ±2.6) was lower than that for males (11.0±2.8; p<0.001). According to ROC analysis, the best cutoffs were 9.0 for males and 6.0 for females. Conclusions: There was a significant difference in the RFS cutoff between the genders. For male subjects, we recommend a cutoff of 9.0 for diagnosing LPRD, and for female subjects, we recommend a cutoff of 6.0. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Different cutoffs of the reflux finding score for diagnosing laryngopharyngeal reflux disease should be used for different genders.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cheng-Kai+Gao%22&quot;&gt;Cheng-Kai Gao&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yan-Fei+Li%22&quot;&gt;Yan-Fei Li&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lu+Wang%22&quot;&gt;Lu Wang&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xiao-Yan+Han%22&quot;&gt;Xiao-Yan Han&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ting+Wu%22&quot;&gt;Ting Wu&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fang-Fang+Zeng%22&quot;&gt;Fang-Fang Zeng&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xiang-Ping+Li%22&quot;&gt;Xiang-Ping Li&lt;/searchLink&gt;
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  Data: Objectives: To assess the differences in Reflux Finding Score (RFS) between the genders and determine the suitable RFS threshold for diagnosing laryngopharyngeal reflux disease (LPRD) in each gender. Methods: Asymptomatic volunteers and patients with LPRD, confirmed with an oropharyngeal Dx-pH monitoring system, were included. All study subjects underwent transnasal flexible fiber-optic video laryngoscopy. Reliability was assessed with intra-class correlation coefficients (ICCs) and Bland-Altman plots. The RFS cutoffs for determining the presence and absence of LPRD between the two genders were examined by receiver operating characteristic (ROC) analysis. Results: One hundred seven asymptomatic volunteers and fifty-five LPRD patients were recruited. The mean RFS for LPRD subjects (9.4&#177;3.2) was significantly higher than that for control subjects (7.1 &#177;2.6; p&lt;0.001). The mean RFS for asymptomatic females (6.1 &#177;2.7) was significantly lower than that for males (7.7 &#177;2.5; p &lt; 0.001). The mean RFS for female subjects with LPRD (7.8 &#177;2.6) was lower than that for males (11.0&#177;2.8; p&lt;0.001). According to ROC analysis, the best cutoffs were 9.0 for males and 6.0 for females. Conclusions: There was a significant difference in the RFS cutoff between the genders. For male subjects, we recommend a cutoff of 9.0 for diagnosing LPRD, and for female subjects, we recommend a cutoff of 6.0. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Acta Oto-Laryngologica (Supplement) is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/00016489.2018.1473642
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      – Code: eng
        Text: English
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        PageCount: 7
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      – SubjectFull: Gastroesophageal reflux diagnosis
        Type: general
      – SubjectFull: Fiber optics
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      – SubjectFull: Laryngoscopy
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      – SubjectFull: Reliability (Personality trait)
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      – SubjectFull: Sex distribution
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      – SubjectFull: Symptoms
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      – SubjectFull: Receiver operating characteristic curves
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      – SubjectFull: Intraclass correlation
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      – TitleFull: Different cutoffs of the reflux finding score for diagnosing laryngopharyngeal reflux disease should be used for different genders.
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            NameFull: Cheng-Kai Gao
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              Text: Sep2018
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