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Global, regional, and country‐level estimates of hepatitis C infection among people who have recently injected drugs.

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Title: Global, regional, and country‐level estimates of hepatitis C infection among people who have recently injected drugs.
Authors: Grebely, Jason, Larney, Sarah, Peacock, Amy, Colledge, Samantha, Leung, Janni, Hickman, Matthew, Vickerman, Peter, Blach, Sarah, Cunningham, Evan B., Dumchev, Kostyantyn, Lynskey, Michael, Stone, Jack, Trickey, Adam, Razavi, Homie, Mattick, Richard P., Farrell, Michael, Dore, Gregory J., Degenhardt, Louisa
Source: Addiction. Jan2019, Vol. 114 Issue 1, p150-166. 17p. 3 Charts, 1 Graph, 3 Maps.
Subjects: Hepatitis C prevention, Intravenous drug abuse, Viral antibodies, World health, Disease prevalence
Abstract: Background and Aims: People who have recently injected drugs are a priority population in efforts to achieve hepatitis C virus (HCV) elimination. This study estimated the prevalence and number of people with recent injecting drug use living with HCV, and the proportion of people with recent injecting drug use among all people living with HCV infection at global, regional and country‐levels. Methods: Data from a global systematic review of injecting drug use and HCV antibody prevalence among people with recent (previous year) injecting drug use were used to estimate the prevalence and number of people with recent injecting drug use living with HCV. These data were combined with a systematic review of global HCV prevalence to estimate the proportion of people with recent injecting drug use among all people living with HCV. Results: There are an estimated 6.1 million [95% uncertainty interval (UI) = 3.4–9.2] people with recent injecting drug use aged 15–64 years living with HCV globally (39.2% viraemic prevalence; UI = 31.6–47.0), with the greatest numbers in East and Southeast Asia (1.5 million, UI = 1.0–2.1), eastern Europe (1.5 million, UI = 0.7–2.4) and North America (1.0 million, UI = 0.4–1.7). People with recent injecting drug use comprise an estimated 8.5% (UI = 4.6–13.1) of all HCV infections globally, with the greatest proportions in North America (30.5%, UI = 11.7–56.7), Latin America (22.0%, UI = 15.3–30.4) and eastern Europe (17.9%, UI = 8.2–30.9). Conclusions: Although, globally, 39.2% of people with recent injecting drug use are living with hepatitis C virus (HCV) and 8.5% of all HCV infections occur globally among people with recent injecting drug use, there is wide variation among countries and regions. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Global, regional, and country‐level estimates of hepatitis C infection among people who have recently injected drugs.
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  Data: <searchLink fieldCode="AR" term="%22Grebely%2C+Jason%22">Grebely, Jason</searchLink><br /><searchLink fieldCode="AR" term="%22Larney%2C+Sarah%22">Larney, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Peacock%2C+Amy%22">Peacock, Amy</searchLink><br /><searchLink fieldCode="AR" term="%22Colledge%2C+Samantha%22">Colledge, Samantha</searchLink><br /><searchLink fieldCode="AR" term="%22Leung%2C+Janni%22">Leung, Janni</searchLink><br /><searchLink fieldCode="AR" term="%22Hickman%2C+Matthew%22">Hickman, Matthew</searchLink><br /><searchLink fieldCode="AR" term="%22Vickerman%2C+Peter%22">Vickerman, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Blach%2C+Sarah%22">Blach, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Cunningham%2C+Evan+B%2E%22">Cunningham, Evan B.</searchLink><br /><searchLink fieldCode="AR" term="%22Dumchev%2C+Kostyantyn%22">Dumchev, Kostyantyn</searchLink><br /><searchLink fieldCode="AR" term="%22Lynskey%2C+Michael%22">Lynskey, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Stone%2C+Jack%22">Stone, Jack</searchLink><br /><searchLink fieldCode="AR" term="%22Trickey%2C+Adam%22">Trickey, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Razavi%2C+Homie%22">Razavi, Homie</searchLink><br /><searchLink fieldCode="AR" term="%22Mattick%2C+Richard+P%2E%22">Mattick, Richard P.</searchLink><br /><searchLink fieldCode="AR" term="%22Farrell%2C+Michael%22">Farrell, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Dore%2C+Gregory+J%2E%22">Dore, Gregory J.</searchLink><br /><searchLink fieldCode="AR" term="%22Degenhardt%2C+Louisa%22">Degenhardt, Louisa</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Jan2019, Vol. 114 Issue 1, p150-166. 17p. 3 Charts, 1 Graph, 3 Maps.
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  Data: <searchLink fieldCode="DE" term="%22Hepatitis+C+prevention%22">Hepatitis C prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+drug+abuse%22">Intravenous drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+antibodies%22">Viral antibodies</searchLink><br /><searchLink fieldCode="DE" term="%22World+health%22">World health</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink>
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  Data: Background and Aims: People who have recently injected drugs are a priority population in efforts to achieve hepatitis C virus (HCV) elimination. This study estimated the prevalence and number of people with recent injecting drug use living with HCV, and the proportion of people with recent injecting drug use among all people living with HCV infection at global, regional and country‐levels. Methods: Data from a global systematic review of injecting drug use and HCV antibody prevalence among people with recent (previous year) injecting drug use were used to estimate the prevalence and number of people with recent injecting drug use living with HCV. These data were combined with a systematic review of global HCV prevalence to estimate the proportion of people with recent injecting drug use among all people living with HCV. Results: There are an estimated 6.1 million [95% uncertainty interval (UI) = 3.4–9.2] people with recent injecting drug use aged 15–64 years living with HCV globally (39.2% viraemic prevalence; UI = 31.6–47.0), with the greatest numbers in East and Southeast Asia (1.5 million, UI = 1.0–2.1), eastern Europe (1.5 million, UI = 0.7–2.4) and North America (1.0 million, UI = 0.4–1.7). People with recent injecting drug use comprise an estimated 8.5% (UI = 4.6–13.1) of all HCV infections globally, with the greatest proportions in North America (30.5%, UI = 11.7–56.7), Latin America (22.0%, UI = 15.3–30.4) and eastern Europe (17.9%, UI = 8.2–30.9). Conclusions: Although, globally, 39.2% of people with recent injecting drug use are living with hepatitis C virus (HCV) and 8.5% of all HCV infections occur globally among people with recent injecting drug use, there is wide variation among countries and regions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/add.14393
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      – SubjectFull: Viral antibodies
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