Serum vitamin D deficiency in subjects with severe acquired brain injury and relationship with functional severity.
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| Title: | Serum vitamin D deficiency in subjects with severe acquired brain injury and relationship with functional severity. |
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| Authors: | Intiso, D., Fontana, A., Copetti, M., Di Rienzo, F. |
| Source: | Brain Injury. 2018, Vol. 32 Issue 13/14, p1817-1823. 7p. |
| Subjects: | Brain injuries, Hospital wards, Hospital admission & discharge, Inflammation, Longitudinal method, Neurology, Patients, Rehabilitation centers, Vitamin D deficiency, Cross-sectional method, Severity of illness index, Diagnosis, Functional assessment |
| Abstract: | Background: Vitamin D may be important for the development and function of the nervous system. Low serum vitamin D levels have been detected in several neurological diseases. Objective: To ascertain the relationship between 25(OH)D serum level and disability in subjects with severe acquired brain injury (sABI). Design: Prospective cross-sectional study Methods: Consecutive subjects with sABI admitted to neuro-rehabilitation were enrolled. A sample of subjects from the neurological ward was considered the control group. Vitamin D serum levels and blood parameters were measured at admission. Disability Rating Scale (DRS), Glasgow Outcome Scale (GOS), and Level of Cognitive Functioning (LCF) were used in assessing disability. Results: A total of 104 subjects (34 F, 70 M; mean age 53.9 ± 15.2 years) were enrolled: 54 (19 F, 35 M) with sABI and 50 (15 F, 35 M) subjects as control group. Deficient mean serum levels of vitamin D (19.2 ± 9.4 ng/mL) were detected in the subjects with sABI and a significant inverse correlation between vitamin D serum levels and DRS score was detected (p = 0.04). Conclusion: Subjects with sABI showed vitamin D deficiency that might correlate to disability severity. The reason is unclear and might represent a secondary phenomenon resulting from the inflammatory process. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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