Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
Saved in:
| Title: | Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes. |
|---|---|
| Authors: | Akilesh, Holly M., Buechler, Matthew B., Duggan, Jeffrey M., Hahn, William O., Matta, Bharati, Sun, Xizhang, Gessay, Griffin, Whalen, Elizabeth, Mason, Michael, Presnell, Scott R., Elkon, Keith B., Lacy-Hulbert, Adam, Barnes, Betsy J., Pepper, Marion, Hamerman, Jessica A. |
| Source: | Science (pre-March 2025). 1/11/2019, Vol. 363 Issue 6423, p142-142. 1p. 1 Diagram. |
| Subjects: | Blood diseases, Blood cell count, Toll-like receptors, Macrophages, Monocytes, Macrophage activation syndrome |
| Abstract: | A summary is presented on an article published online at http://dx.doi.org/10.1126/science.aao5213 examining how signaling through Toll-like receptors in macrophages and/or monocytes participates in infection- and inflammation-associated cytopenias.It speculates that macrophage activation syndrome, a complication of viral infections associated with acute cytopenias and of rheumatological diseases, could be the result of inflammatory hemophagocytes which also drive severe malarial anemia. |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | A summary is presented on an article published online at http://dx.doi.org/10.1126/science.aao5213 examining how signaling through Toll-like receptors in macrophages and/or monocytes participates in infection- and inflammation-associated cytopenias.It speculates that macrophage activation syndrome, a complication of viral infections associated with acute cytopenias and of rheumatological diseases, could be the result of inflammatory hemophagocytes which also drive severe malarial anemia. |
|---|---|
| ISSN: | 00368075 |
| DOI: | 10.1126/science.aao5213 |
