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Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.

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Title: Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
Authors: Akilesh, Holly M., Buechler, Matthew B., Duggan, Jeffrey M., Hahn, William O., Matta, Bharati, Sun, Xizhang, Gessay, Griffin, Whalen, Elizabeth, Mason, Michael, Presnell, Scott R., Elkon, Keith B., Lacy-Hulbert, Adam, Barnes, Betsy J., Pepper, Marion, Hamerman, Jessica A.
Source: Science (pre-March 2025). 1/11/2019, Vol. 363 Issue 6423, p142-142. 1p. 1 Diagram.
Subjects: Blood diseases, Blood cell count, Toll-like receptors, Macrophages, Monocytes, Macrophage activation syndrome
Abstract: A summary is presented on an article published online at http://dx.doi.org/10.1126/science.aao5213 examining how signaling through Toll-like receptors in macrophages and/or monocytes participates in infection- and inflammation-associated cytopenias.It speculates that macrophage activation syndrome, a complication of viral infections associated with acute cytopenias and of rheumatological diseases, could be the result of inflammatory hemophagocytes which also drive severe malarial anemia.
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
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  Data: <searchLink fieldCode="AR" term="%22Akilesh%2C+Holly+M%2E%22">Akilesh, Holly M.</searchLink><br /><searchLink fieldCode="AR" term="%22Buechler%2C+Matthew+B%2E%22">Buechler, Matthew B.</searchLink><br /><searchLink fieldCode="AR" term="%22Duggan%2C+Jeffrey+M%2E%22">Duggan, Jeffrey M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hahn%2C+William+O%2E%22">Hahn, William O.</searchLink><br /><searchLink fieldCode="AR" term="%22Matta%2C+Bharati%22">Matta, Bharati</searchLink><br /><searchLink fieldCode="AR" term="%22Sun%2C+Xizhang%22">Sun, Xizhang</searchLink><br /><searchLink fieldCode="AR" term="%22Gessay%2C+Griffin%22">Gessay, Griffin</searchLink><br /><searchLink fieldCode="AR" term="%22Whalen%2C+Elizabeth%22">Whalen, Elizabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Mason%2C+Michael%22">Mason, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Presnell%2C+Scott+R%2E%22">Presnell, Scott R.</searchLink><br /><searchLink fieldCode="AR" term="%22Elkon%2C+Keith+B%2E%22">Elkon, Keith B.</searchLink><br /><searchLink fieldCode="AR" term="%22Lacy-Hulbert%2C+Adam%22">Lacy-Hulbert, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Barnes%2C+Betsy+J%2E%22">Barnes, Betsy J.</searchLink><br /><searchLink fieldCode="AR" term="%22Pepper%2C+Marion%22">Pepper, Marion</searchLink><br /><searchLink fieldCode="AR" term="%22Hamerman%2C+Jessica+A%2E%22">Hamerman, Jessica A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 1/11/2019, Vol. 363 Issue 6423, p142-142. 1p. 1 Diagram.
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  Data: <searchLink fieldCode="DE" term="%22Blood+diseases%22">Blood diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+cell+count%22">Blood cell count</searchLink><br /><searchLink fieldCode="DE" term="%22Toll-like+receptors%22">Toll-like receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22Monocytes%22">Monocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophage+activation+syndrome%22">Macrophage activation syndrome</searchLink>
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  Data: A summary is presented on an article published online at http://dx.doi.org/10.1126/science.aao5213 examining how signaling through Toll-like receptors in macrophages and/or monocytes participates in infection- and inflammation-associated cytopenias.It speculates that macrophage activation syndrome, a complication of viral infections associated with acute cytopenias and of rheumatological diseases, could be the result of inflammatory hemophagocytes which also drive severe malarial anemia.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=134157748
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        Text: English
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      – SubjectFull: Toll-like receptors
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              Text: 1/11/2019
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              Y: 2019
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