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Setting Priorities for Genomic Research.

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Title: Setting Priorities for Genomic Research.
Authors: Berrettini, Wade, Bierut, Laura, Crowley, Thomas J., Cubells, Joseph F., Frascella, Joseph, Gelernter, Joel, Hewttt, John K., Kreek, Mary Jeanne, Lachman, Herb, Leppert, Mark, Li, Ming D., Madden, Pamela, Miner, Cindy, Pollock, Jonathan D., Pomerleau, Ovide, Rice, John P., Rutter, Joni L, Shurtleff, David, Swan, Gary E., Tischfeld, Jay A.
Source: Science (pre-March 2025). 6/4/2004, Vol. 304 Issue 5676, p1445-1446. 2p.
Subjects: Genomics, Genetic disorders, Substance abuse, Vaccines, Opioid receptors, Polymorphism (Zoology)
Abstract: K. R. Merikangas and N. Risen propose that diseases appearing to be highly amenable to environmental modification should take low priority in genomic research. Their conclusions ignore the large public health burden of complex genetic diseases like alcohol, nicotine and other substance abuse disorders, which cost society over $500 billion per year. Twin studies consistently show that genetic contributions for substance dependence account for half the disease variance. The A118G μ-opioid receptor polymorphism shows a preliminary association with therapeutic response to naltrexone treatment for alcoholism, implicating targeted treatment for alcoholics carrying 118G.
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 13455797
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Setting Priorities for Genomic Research.
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  Data: <searchLink fieldCode="AR" term="%22Berrettini%2C+Wade%22">Berrettini, Wade</searchLink><br /><searchLink fieldCode="AR" term="%22Bierut%2C+Laura%22">Bierut, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Crowley%2C+Thomas+J%2E%22">Crowley, Thomas J.</searchLink><br /><searchLink fieldCode="AR" term="%22Cubells%2C+Joseph+F%2E%22">Cubells, Joseph F.</searchLink><br /><searchLink fieldCode="AR" term="%22Frascella%2C+Joseph%22">Frascella, Joseph</searchLink><br /><searchLink fieldCode="AR" term="%22Gelernter%2C+Joel%22">Gelernter, Joel</searchLink><br /><searchLink fieldCode="AR" term="%22Hewttt%2C+John+K%2E%22">Hewttt, John K.</searchLink><br /><searchLink fieldCode="AR" term="%22Kreek%2C+Mary+Jeanne%22">Kreek, Mary Jeanne</searchLink><br /><searchLink fieldCode="AR" term="%22Lachman%2C+Herb%22">Lachman, Herb</searchLink><br /><searchLink fieldCode="AR" term="%22Leppert%2C+Mark%22">Leppert, Mark</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Ming+D%2E%22">Li, Ming D.</searchLink><br /><searchLink fieldCode="AR" term="%22Madden%2C+Pamela%22">Madden, Pamela</searchLink><br /><searchLink fieldCode="AR" term="%22Miner%2C+Cindy%22">Miner, Cindy</searchLink><br /><searchLink fieldCode="AR" term="%22Pollock%2C+Jonathan+D%2E%22">Pollock, Jonathan D.</searchLink><br /><searchLink fieldCode="AR" term="%22Pomerleau%2C+Ovide%22">Pomerleau, Ovide</searchLink><br /><searchLink fieldCode="AR" term="%22Rice%2C+John+P%2E%22">Rice, John P.</searchLink><br /><searchLink fieldCode="AR" term="%22Rutter%2C+Joni+L%22">Rutter, Joni L</searchLink><br /><searchLink fieldCode="AR" term="%22Shurtleff%2C+David%22">Shurtleff, David</searchLink><br /><searchLink fieldCode="AR" term="%22Swan%2C+Gary+E%2E%22">Swan, Gary E.</searchLink><br /><searchLink fieldCode="AR" term="%22Tischfeld%2C+Jay+A%2E%22">Tischfeld, Jay A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/4/2004, Vol. 304 Issue 5676, p1445-1446. 2p.
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  Data: <searchLink fieldCode="DE" term="%22Genomics%22">Genomics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccines%22">Vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Opioid+receptors%22">Opioid receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism+%28Zoology%29%22">Polymorphism (Zoology)</searchLink>
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  Label: Abstract
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  Data: K. R. Merikangas and N. Risen propose that diseases appearing to be highly amenable to environmental modification should take low priority in genomic research. Their conclusions ignore the large public health burden of complex genetic diseases like alcohol, nicotine and other substance abuse disorders, which cost society over $500 billion per year. Twin studies consistently show that genetic contributions for substance dependence account for half the disease variance. The A118G μ-opioid receptor polymorphism shows a preliminary association with therapeutic response to naltrexone treatment for alcoholism, implicating targeted treatment for alcoholics carrying 118G.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=13455797
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      – SubjectFull: Substance abuse
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      – SubjectFull: Vaccines
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      – SubjectFull: Opioid receptors
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      – SubjectFull: Polymorphism (Zoology)
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              Text: 6/4/2004
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