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Uric acid level may not be reduced in essential tremor.

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Title: Uric acid level may not be reduced in essential tremor.
Authors: Lee, Chae Young, Yoon, Jung Han, Park, Jeong-Ho, Hong, Jin Yong, Sunwoo, Mun Kyung, Kang, Suk Yun
Source: International Journal of Neuroscience. Dec2018, Vol. 128 Issue 12, p1163-1167. 5p.
Subjects: Essential tremor, Uric acid
Abstract: Background: Essential tremor is very common, but characterization is difficult because of its heterogeneity. Neuropathology is important to elucidate the characteristics of neurological disorders. However, pathological findings in essential tremor have been inconsistent among studies. Uric acid is a strong antioxidant and might be a biomarker in neurodegenerative process. We hypothesized that uric acid level would be reduced if essential tremor is a neurodegenerative disease. Our aim was to compare uric acid level between essential tremor patients and healthy individuals. Methods: This was a prospective, case-control, multicenter study with 92 essential tremor patients and 77 healthy subjects. For homogeneity, the essential tremor group was subdivided into two groups (hereditary and sporadic). Clinical and laboratory findings were compared among the essential tremor and healthy groups. Results: The demographic characteristics were comparable among the groups. The uric acid level was lower in the essential tremor group than in healthy subjects, but the difference did not reach statistical significance. There was a negative correlation between uric acid level and disease duration in the hereditary group (p = .046) and between uric acid level and age at onset in the sporadic group (p = .012). The mean values of total cholesterol were significantly lower in the sporadic group than in the other groups (p = .011). Total cholesterol was positively correlated with age at onset in the hereditary essential tremor group (p = .010). Conclusions: We did not find any evidence that uric acid levels suggested essential tremor is a neurodegenerative disease. However, further research with more patients might be needed given the negative correlations of disease duration and age at onset with uric acid level. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Uric acid level may not be reduced in essential tremor.
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  Data: <searchLink fieldCode="AR" term="%22Lee%2C+Chae+Young%22">Lee, Chae Young</searchLink><br /><searchLink fieldCode="AR" term="%22Yoon%2C+Jung+Han%22">Yoon, Jung Han</searchLink><br /><searchLink fieldCode="AR" term="%22Park%2C+Jeong-Ho%22">Park, Jeong-Ho</searchLink><br /><searchLink fieldCode="AR" term="%22Hong%2C+Jin+Yong%22">Hong, Jin Yong</searchLink><br /><searchLink fieldCode="AR" term="%22Sunwoo%2C+Mun+Kyung%22">Sunwoo, Mun Kyung</searchLink><br /><searchLink fieldCode="AR" term="%22Kang%2C+Suk+Yun%22">Kang, Suk Yun</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec2018, Vol. 128 Issue 12, p1163-1167. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Essential+tremor%22">Essential tremor</searchLink><br /><searchLink fieldCode="DE" term="%22Uric+acid%22">Uric acid</searchLink>
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  Label: Abstract
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  Data: Background: Essential tremor is very common, but characterization is difficult because of its heterogeneity. Neuropathology is important to elucidate the characteristics of neurological disorders. However, pathological findings in essential tremor have been inconsistent among studies. Uric acid is a strong antioxidant and might be a biomarker in neurodegenerative process. We hypothesized that uric acid level would be reduced if essential tremor is a neurodegenerative disease. Our aim was to compare uric acid level between essential tremor patients and healthy individuals. Methods: This was a prospective, case-control, multicenter study with 92 essential tremor patients and 77 healthy subjects. For homogeneity, the essential tremor group was subdivided into two groups (hereditary and sporadic). Clinical and laboratory findings were compared among the essential tremor and healthy groups. Results: The demographic characteristics were comparable among the groups. The uric acid level was lower in the essential tremor group than in healthy subjects, but the difference did not reach statistical significance. There was a negative correlation between uric acid level and disease duration in the hereditary group (p = .046) and between uric acid level and age at onset in the sporadic group (p = .012). The mean values of total cholesterol were significantly lower in the sporadic group than in the other groups (p = .011). Total cholesterol was positively correlated with age at onset in the hereditary essential tremor group (p = .010). Conclusions: We did not find any evidence that uric acid levels suggested essential tremor is a neurodegenerative disease. However, further research with more patients might be needed given the negative correlations of disease duration and age at onset with uric acid level. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00207454.2018.1492574
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              Text: Dec2018
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