View in EDS

Neurocognition and adaptive functioning in a genetic high risk model of schizophrenia.

Saved in:
Bibliographic Details
Title: Neurocognition and adaptive functioning in a genetic high risk model of schizophrenia.
Authors: Fiksinski, A. M., Breetvelt, E. J., Lee, Y. J., Boot, E., Butcher, N., Palmer, L., Chow, E. W. C., Kahn, R. S., Vorstman, J. A. S., Bassett, A. S.
Source: Psychological Medicine. Apr2019, Vol. 49 Issue 6, p1047-1054. 8p.
Subjects: Genetics of schizophrenia, Schizophrenia risk factors, Adaptability (Personality), Age distribution, Cognitive testing, Factor analysis, Health status indicators, Life skills, Mathematical models, Neuropsychological tests, Memory, Psychology of movement, Psychology, Psychoses, Regression analysis, 22q11 deletion syndrome
Abstract: Background: Identifying factors that influence the functional outcome is an important goal in schizophrenia research. The 22q11.2 deletion syndrome (22q11DS) is a unique genetic model with high risk (20–25%) for schizophrenia. This study aimed to identify potentially targetable domains of neurocognitive functioning associated with functional outcome in adults with 22q11DS. Methods: We used comprehensive neurocognitive test data available for 99 adults with 22q11DS (n = 43 with schizophrenia) and principal component analysis to derive four domains of neurocognition (Verbal Memory, Visual and Logical Memory, Motor Performance, and Executive Performance). We then investigated the association of these neurocognitive domains with adaptive functioning using Vineland Adaptive Behavior Scales data and a linear regression model that accounted for the effects of schizophrenia status and overall intellectual level. Results: The regression model explained 46.8% of the variance in functional outcome (p < 0.0001). Executive Performance was significantly associated with functional outcome (p = 0.048). Age and schizophrenia were also significant factors. The effects of Executive Performance on functioning did not significantly differ between those with and without psychotic illness. Conclusion: The findings provide the impetus for further studies to examine the potential of directed (early) interventions targeting Executive Performance to improve long-term adaptive functional outcome in individuals with, or at high risk for, schizophrenia. Moreover, the neurocognitive test profiles may benefit caregivers and clinicians by providing insight into the relative strengths and weaknesses of individuals with 22q11DS, with and without psychotic illness. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 135430222
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neurocognition and adaptive functioning in a genetic high risk model of schizophrenia.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fiksinski%2C+A%2E+M%2E%22&quot;&gt;Fiksinski, A. M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Breetvelt%2C+E%2E+J%2E%22&quot;&gt;Breetvelt, E. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lee%2C+Y%2E+J%2E%22&quot;&gt;Lee, Y. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Boot%2C+E%2E%22&quot;&gt;Boot, E.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Butcher%2C+N%2E%22&quot;&gt;Butcher, N.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Palmer%2C+L%2E%22&quot;&gt;Palmer, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chow%2C+E%2E+W%2E+C%2E%22&quot;&gt;Chow, E. W. C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kahn%2C+R%2E+S%2E%22&quot;&gt;Kahn, R. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vorstman%2C+J%2E+A%2E+S%2E%22&quot;&gt;Vorstman, J. A. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bassett%2C+A%2E+S%2E%22&quot;&gt;Bassett, A. S.&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychological+Medicine%22&quot;&gt;Psychological Medicine&lt;/searchLink&gt;. Apr2019, Vol. 49 Issue 6, p1047-1054. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetics+of+schizophrenia%22&quot;&gt;Genetics of schizophrenia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Schizophrenia+risk+factors%22&quot;&gt;Schizophrenia risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adaptability+%28Personality%29%22&quot;&gt;Adaptability (Personality)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Age+distribution%22&quot;&gt;Age distribution&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognitive+testing%22&quot;&gt;Cognitive testing&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Factor+analysis%22&quot;&gt;Factor analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Health+status+indicators%22&quot;&gt;Health status indicators&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Life+skills%22&quot;&gt;Life skills&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mathematical+models%22&quot;&gt;Mathematical models&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neuropsychological+tests%22&quot;&gt;Neuropsychological tests&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Memory%22&quot;&gt;Memory&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychology+of+movement%22&quot;&gt;Psychology of movement&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychology%22&quot;&gt;Psychology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychoses%22&quot;&gt;Psychoses&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Regression+analysis%22&quot;&gt;Regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%2222q11+deletion+syndrome%22&quot;&gt;22q11 deletion syndrome&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Identifying factors that influence the functional outcome is an important goal in schizophrenia research. The 22q11.2 deletion syndrome (22q11DS) is a unique genetic model with high risk (20–25%) for schizophrenia. This study aimed to identify potentially targetable domains of neurocognitive functioning associated with functional outcome in adults with 22q11DS. Methods: We used comprehensive neurocognitive test data available for 99 adults with 22q11DS (n = 43 with schizophrenia) and principal component analysis to derive four domains of neurocognition (Verbal Memory, Visual and Logical Memory, Motor Performance, and Executive Performance). We then investigated the association of these neurocognitive domains with adaptive functioning using Vineland Adaptive Behavior Scales data and a linear regression model that accounted for the effects of schizophrenia status and overall intellectual level. Results: The regression model explained 46.8% of the variance in functional outcome (p &lt; 0.0001). Executive Performance was significantly associated with functional outcome (p = 0.048). Age and schizophrenia were also significant factors. The effects of Executive Performance on functioning did not significantly differ between those with and without psychotic illness. Conclusion: The findings provide the impetus for further studies to examine the potential of directed (early) interventions targeting Executive Performance to improve long-term adaptive functional outcome in individuals with, or at high risk for, schizophrenia. Moreover, the neurocognitive test profiles may benefit caregivers and clinicians by providing insight into the relative strengths and weaknesses of individuals with 22q11DS, with and without psychotic illness. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=135430222
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291718001824
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1047
    Subjects:
      – SubjectFull: Genetics of schizophrenia
        Type: general
      – SubjectFull: Schizophrenia risk factors
        Type: general
      – SubjectFull: Adaptability (Personality)
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Cognitive testing
        Type: general
      – SubjectFull: Factor analysis
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Life skills
        Type: general
      – SubjectFull: Mathematical models
        Type: general
      – SubjectFull: Neuropsychological tests
        Type: general
      – SubjectFull: Memory
        Type: general
      – SubjectFull: Psychology of movement
        Type: general
      – SubjectFull: Psychology
        Type: general
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: 22q11 deletion syndrome
        Type: general
    Titles:
      – TitleFull: Neurocognition and adaptive functioning in a genetic high risk model of schizophrenia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fiksinski, A. M.
      – PersonEntity:
          Name:
            NameFull: Breetvelt, E. J.
      – PersonEntity:
          Name:
            NameFull: Lee, Y. J.
      – PersonEntity:
          Name:
            NameFull: Boot, E.
      – PersonEntity:
          Name:
            NameFull: Butcher, N.
      – PersonEntity:
          Name:
            NameFull: Palmer, L.
      – PersonEntity:
          Name:
            NameFull: Chow, E. W. C.
      – PersonEntity:
          Name:
            NameFull: Kahn, R. S.
      – PersonEntity:
          Name:
            NameFull: Vorstman, J. A. S.
      – PersonEntity:
          Name:
            NameFull: Bassett, A. S.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 04
              Text: Apr2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 00332917
          Numbering:
            – Type: volume
              Value: 49
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Psychological Medicine
              Type: main
ResultId 1