Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula.
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| Title: | Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula. |
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| Authors: | Saga, Yosuke (AUTHOR), Ruff, Christian C. (AUTHOR), Tremblay, Léon (AUTHOR) |
| Source: | European Journal of Neuroscience. Mar2019, Vol. 49 Issue 5, p687-700. 14p. 1 Diagram, 1 Chart, 5 Graphs. |
| Subjects: | Basal ganglia, Primate behavior, Aversive stimuli, Thalamic nuclei, Cell nuclei, Globus pallidus, Approach behavior, Action theory (Psychology) |
| Abstract: | The basal ganglia (BG) are involved in motivation and goal‐directed behavior. Recent studies suggest that limbic territories of BG not only support reward seeking (appetitive approach) but also the encoding of aversive conditioned stimuli (CS) and the production of aversive‐related behaviors (avoidance or escape). This study aimed to identify inside two BG nuclei, the striatum and pallidum, the territories involved in aversive behaviors and to compare the effects of stimulating these territories to those resulting from stimulation of the anterior Insula (aIns), a region that is well‐known to be involved in aversive encoding and associated behaviors. Two monkeys performed an approach/avoidance task in which they had to choose a behavior (approach or avoidance) in an appetitive (reward) or aversive (air‐puff) context. During this task, either one (single‐cue) or two (dual‐cue) CS provided essential information about which context‐adapted behavior should be selected. Microstimulation was applied during the CS presentation. Stimulation generally reduced approaches in the appetitive contexts and increased escape behaviors (premature responses) and/or passive avoidance (noninitiated action) in aversive context. These effects were more pronounced in ventral parts of all examined structures, with significant differences observed between stimulated structures. Thresholds to induce effects were lowest in the pallidum. Striatal stimulation led to the largest diversity of effects, with a subregion even leading to enhanced active avoidance. Finally, aIns stimulations produced stronger effects in the dual‐cue context. These results provide causal evidence that limbic territories of BG, like aIns, play crucial roles in the selection of context‐motivated behaviors. Microstimulation was applied in basal ganglia and anterior Insula of monkeys performing an approach‐avoidance task. Stimulation of ventral parts of all structures reduced approach behavior and increased aversive behavior. The pallidum was the most effective site for inducing aversive behavior and the ventral striatum the only site improving avoidance. This provides causal evidence that BG limbic territories and aIns play crucial roles in both aversive and appetitive behavior. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 135444765 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Saga%2C+Yosuke%22">Saga, Yosuke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruff%2C+Christian+C%2E%22">Ruff, Christian C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tremblay%2C+Léon%22">Tremblay, Léon</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2019, Vol. 49 Issue 5, p687-700. 14p. 1 Diagram, 1 Chart, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Basal+ganglia%22">Basal ganglia</searchLink><br /><searchLink fieldCode="DE" term="%22Primate+behavior%22">Primate behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Aversive+stimuli%22">Aversive stimuli</searchLink><br /><searchLink fieldCode="DE" term="%22Thalamic+nuclei%22">Thalamic nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+nuclei%22">Cell nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Globus+pallidus%22">Globus pallidus</searchLink><br /><searchLink fieldCode="DE" term="%22Approach+behavior%22">Approach behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Action+theory+%28Psychology%29%22">Action theory (Psychology)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The basal ganglia (BG) are involved in motivation and goal‐directed behavior. Recent studies suggest that limbic territories of BG not only support reward seeking (appetitive approach) but also the encoding of aversive conditioned stimuli (CS) and the production of aversive‐related behaviors (avoidance or escape). This study aimed to identify inside two BG nuclei, the striatum and pallidum, the territories involved in aversive behaviors and to compare the effects of stimulating these territories to those resulting from stimulation of the anterior Insula (aIns), a region that is well‐known to be involved in aversive encoding and associated behaviors. Two monkeys performed an approach/avoidance task in which they had to choose a behavior (approach or avoidance) in an appetitive (reward) or aversive (air‐puff) context. During this task, either one (single‐cue) or two (dual‐cue) CS provided essential information about which context‐adapted behavior should be selected. Microstimulation was applied during the CS presentation. Stimulation generally reduced approaches in the appetitive contexts and increased escape behaviors (premature responses) and/or passive avoidance (noninitiated action) in aversive context. These effects were more pronounced in ventral parts of all examined structures, with significant differences observed between stimulated structures. Thresholds to induce effects were lowest in the pallidum. Striatal stimulation led to the largest diversity of effects, with a subregion even leading to enhanced active avoidance. Finally, aIns stimulations produced stronger effects in the dual‐cue context. These results provide causal evidence that limbic territories of BG, like aIns, play crucial roles in the selection of context‐motivated behaviors. Microstimulation was applied in basal ganglia and anterior Insula of monkeys performing an approach‐avoidance task. Stimulation of ventral parts of all structures reduced approach behavior and increased aversive behavior. The pallidum was the most effective site for inducing aversive behavior and the ventral striatum the only site improving avoidance. This provides causal evidence that BG limbic territories and aIns play crucial roles in both aversive and appetitive behavior. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.14201 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 687 Subjects: – SubjectFull: Basal ganglia Type: general – SubjectFull: Primate behavior Type: general – SubjectFull: Aversive stimuli Type: general – SubjectFull: Thalamic nuclei Type: general – SubjectFull: Cell nuclei Type: general – SubjectFull: Globus pallidus Type: general – SubjectFull: Approach behavior Type: general – SubjectFull: Action theory (Psychology) Type: general Titles: – TitleFull: Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Saga, Yosuke – PersonEntity: Name: NameFull: Ruff, Christian C. – PersonEntity: Name: NameFull: Tremblay, Léon IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 49 – Type: issue Value: 5 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
