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Cognitive behavioural therapy for post-stroke fatigue and sleep disturbance: a pilot randomised controlled trial with blind assessment.

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Title: Cognitive behavioural therapy for post-stroke fatigue and sleep disturbance: a pilot randomised controlled trial with blind assessment.
Authors: Nguyen, Sylvia, Wong, Dana, McKay, Adam, Rajaratnam, Shantha M.W., Spitz, Gershon, Williams, Gavin, Mansfield, Darren, Ponsford, Jennie L.
Source: Neuropsychological Rehabilitation. Jun2019, Vol. 29 Issue 5, p723-738. 16p. 1 Diagram, 3 Charts, 1 Graph.
Subjects: Cognitive therapy, Stroke, Insomnia, Rehabilitation, Sleep disorders
Abstract: The objective of this study was to evaluate the effectiveness of individual cognitive behavioural therapy (CBT) for post-stroke fatigue and sleep disturbance compared to treatment as usual (TAU). In a parallel two-group pilot randomised controlled trial of 15 participants, nine were allocated to eight weekly sessions of adapted CBT and six continued usual care rehabilitation. The primary outcome was the Fatigue Severity Scale (FSS-7) at two and four months from baseline. Secondary outcomes included measures of sleep, mood and quality of life. Outcomes were assessed by a rater who was blind to group membership. At the four-month endpoint, the CBT group demonstrated significantly reduced fatigue relative to TAU (FSS-7 mean difference: 1.92, 95% CI: 0.24 to 3.60). Significant group differences also emerged for sleep quality and depression, favouring the CBT group. Insomnia and physical quality of life improved immediately post-therapy but were no longer superior to TAU at follow-up. Overall, CBT is a promising treatment for improving post-stroke fatigue, sleep quality and depression. Gains were maintained for two months after therapy cessation and represented large treatment effects. These findings highlight the feasibility of the intervention and warrant extension to a phase III clinical trial. [ABSTRACT FROM AUTHOR]
Copyright of Neuropsychological Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cognitive behavioural therapy for post-stroke fatigue and sleep disturbance: a pilot randomised controlled trial with blind assessment.
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  Data: <searchLink fieldCode="AR" term="%22Nguyen%2C+Sylvia%22">Nguyen, Sylvia</searchLink><br /><searchLink fieldCode="AR" term="%22Wong%2C+Dana%22">Wong, Dana</searchLink><br /><searchLink fieldCode="AR" term="%22McKay%2C+Adam%22">McKay, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Rajaratnam%2C+Shantha+M%2EW%2E%22">Rajaratnam, Shantha M.W.</searchLink><br /><searchLink fieldCode="AR" term="%22Spitz%2C+Gershon%22">Spitz, Gershon</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Gavin%22">Williams, Gavin</searchLink><br /><searchLink fieldCode="AR" term="%22Mansfield%2C+Darren%22">Mansfield, Darren</searchLink><br /><searchLink fieldCode="AR" term="%22Ponsford%2C+Jennie+L%2E%22">Ponsford, Jennie L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Neuropsychological+Rehabilitation%22">Neuropsychological Rehabilitation</searchLink>. Jun2019, Vol. 29 Issue 5, p723-738. 16p. 1 Diagram, 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Insomnia%22">Insomnia</searchLink><br /><searchLink fieldCode="DE" term="%22Rehabilitation%22">Rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The objective of this study was to evaluate the effectiveness of individual cognitive behavioural therapy (CBT) for post-stroke fatigue and sleep disturbance compared to treatment as usual (TAU). In a parallel two-group pilot randomised controlled trial of 15 participants, nine were allocated to eight weekly sessions of adapted CBT and six continued usual care rehabilitation. The primary outcome was the Fatigue Severity Scale (FSS-7) at two and four months from baseline. Secondary outcomes included measures of sleep, mood and quality of life. Outcomes were assessed by a rater who was blind to group membership. At the four-month endpoint, the CBT group demonstrated significantly reduced fatigue relative to TAU (FSS-7 mean difference: 1.92, 95% CI: 0.24 to 3.60). Significant group differences also emerged for sleep quality and depression, favouring the CBT group. Insomnia and physical quality of life improved immediately post-therapy but were no longer superior to TAU at follow-up. Overall, CBT is a promising treatment for improving post-stroke fatigue, sleep quality and depression. Gains were maintained for two months after therapy cessation and represented large treatment effects. These findings highlight the feasibility of the intervention and warrant extension to a phase III clinical trial. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neuropsychological Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/09602011.2017.1326945
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        Text: English
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        Type: general
      – SubjectFull: Stroke
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      – SubjectFull: Insomnia
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      – SubjectFull: Rehabilitation
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      – SubjectFull: Sleep disorders
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              Text: Jun2019
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              Y: 2019
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