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Oxytocin modulates social value representations in the amygdala.

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Title: Oxytocin modulates social value representations in the amygdala.
Authors: Liu, Yunzhe (AUTHOR), Li, Shiyi (AUTHOR), Lin, Wanjun (AUTHOR), Li, Wenxin (AUTHOR), Yan, Xinyuan (AUTHOR), Wang, Xuena (AUTHOR), Pan, Xinyue (AUTHOR), Rutledge, Robb B. (AUTHOR), Ma, Yina (AUTHOR)
Source: Nature Neuroscience. Apr2019, Vol. 22 Issue 4, p633-641. 9p. 4 Graphs.
Abstract: Humans exhibit considerable variation in how they value their own interest relative to the interests of others. Deciphering the neural codes representing potential rewards for self and others is crucial for understanding social decision-making. Here we integrate computational modeling with functional magnetic resonance imaging to investigate the neural representation of social value and the modulation by oxytocin, a nine-amino acid neuropeptide, in participants evaluating monetary allocations to self and other (self–other allocations). We found that an individual's preferred self–other allocation serves as a reference point for computing the value of potential self–other allocations. In more prosocial participants, amygdala activity encoded a social-value-distance signal; that is, the value dissimilarity between potential and preferred allocations. Intranasal oxytocin administration amplified this amygdala representation and increased prosocial behavior in more individualistic participants but not in more prosocial ones. Our results reveal a neurocomputational mechanism underlying social-value representations and suggest that oxytocin may promote prosociality by modulating social-value representations in the amygdala. Using a behaviorally obtained reference point to compute social value, Ma et al. show that social-value distance is encoded by the amygdala in prosocials. Oxytocin amplifies this amygdala representation and increases prosociality in individualists. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Oxytocin modulates social value representations in the amygdala.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Yunzhe%22">Liu, Yunzhe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Shiyi%22">Li, Shiyi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Wanjun%22">Lin, Wanjun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Wenxin%22">Li, Wenxin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Xinyuan%22">Yan, Xinyuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Xuena%22">Wang, Xuena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pan%2C+Xinyue%22">Pan, Xinyue</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rutledge%2C+Robb+B%2E%22">Rutledge, Robb B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Yina%22">Ma, Yina</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Apr2019, Vol. 22 Issue 4, p633-641. 9p. 4 Graphs.
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  Label: Abstract
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  Data: Humans exhibit considerable variation in how they value their own interest relative to the interests of others. Deciphering the neural codes representing potential rewards for self and others is crucial for understanding social decision-making. Here we integrate computational modeling with functional magnetic resonance imaging to investigate the neural representation of social value and the modulation by oxytocin, a nine-amino acid neuropeptide, in participants evaluating monetary allocations to self and other (self–other allocations). We found that an individual's preferred self–other allocation serves as a reference point for computing the value of potential self–other allocations. In more prosocial participants, amygdala activity encoded a social-value-distance signal; that is, the value dissimilarity between potential and preferred allocations. Intranasal oxytocin administration amplified this amygdala representation and increased prosocial behavior in more individualistic participants but not in more prosocial ones. Our results reveal a neurocomputational mechanism underlying social-value representations and suggest that oxytocin may promote prosociality by modulating social-value representations in the amygdala. Using a behaviorally obtained reference point to compute social value, Ma et al. show that social-value distance is encoded by the amygdala in prosocials. Oxytocin amplifies this amygdala representation and increases prosociality in individualists. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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