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Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients.

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Title: Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients.
Authors: Pinter, D., Enzinger, C., Gattringer, T., Eppinger, S., Niederkorn, K., Horner, S., Fandler, S., Kneihsl, M., Krenn, K., Bachmaier, G., Fazekas, F.
Source: European Journal of Neurology. May2019, Vol. 26 Issue 5, p727-732. 6p. 3 Charts, 1 Graph.
Subjects: Stroke patients, Multi-infarct dementia, Unilateral neglect, Standard deviations, Disease prevalence, Hospital admission & discharge
Abstract: Background and purpose: Information on the prevalence and course of post‐stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample of acute young ischaemic stroke patients (18–55 years) for the presence and development of neuropsychological deficits. Methods: Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first 3 weeks after hospital admission (median assessment at day 6) and at a 3 months' follow‐up (FU). Cognitive dysfunction was defined in comparison to age‐standardized published norms. Results: At baseline (N = 114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N = 87). In most domains, cognitive performance improved within 3 months, except for word fluency. However, in about one‐third of patients, cognitive deficits (as defined by 1.5 standard deviations below the standardized mean) were still present 3 months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention. Conclusions: The high prevalence of cognitive deficits in acute young patients with ischaemic stroke highlights the importance of early post‐stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients.
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  Data: <searchLink fieldCode="AR" term="%22Pinter%2C+D%2E%22">Pinter, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Enzinger%2C+C%2E%22">Enzinger, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Gattringer%2C+T%2E%22">Gattringer, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Eppinger%2C+S%2E%22">Eppinger, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Niederkorn%2C+K%2E%22">Niederkorn, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Horner%2C+S%2E%22">Horner, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Fandler%2C+S%2E%22">Fandler, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Kneihsl%2C+M%2E%22">Kneihsl, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Krenn%2C+K%2E%22">Krenn, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Bachmaier%2C+G%2E%22">Bachmaier, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Fazekas%2C+F%2E%22">Fazekas, F.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. May2019, Vol. 26 Issue 5, p727-732. 6p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Stroke+patients%22">Stroke patients</searchLink><br /><searchLink fieldCode="DE" term="%22Multi-infarct+dementia%22">Multi-infarct dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Unilateral+neglect%22">Unilateral neglect</searchLink><br /><searchLink fieldCode="DE" term="%22Standard+deviations%22">Standard deviations</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+admission+%26+discharge%22">Hospital admission & discharge</searchLink>
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  Data: Background and purpose: Information on the prevalence and course of post‐stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample of acute young ischaemic stroke patients (18–55 years) for the presence and development of neuropsychological deficits. Methods: Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first 3 weeks after hospital admission (median assessment at day 6) and at a 3 months' follow‐up (FU). Cognitive dysfunction was defined in comparison to age‐standardized published norms. Results: At baseline (N = 114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N = 87). In most domains, cognitive performance improved within 3 months, except for word fluency. However, in about one‐third of patients, cognitive deficits (as defined by 1.5 standard deviations below the standardized mean) were still present 3 months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention. Conclusions: The high prevalence of cognitive deficits in acute young patients with ischaemic stroke highlights the importance of early post‐stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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