Early‐morning OFF and levodopa dose failures in patients with Parkinson's disease attending a routine clinical appointment using Time‐to‐ON Questionnaire.
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| Title: | Early‐morning OFF and levodopa dose failures in patients with Parkinson's disease attending a routine clinical appointment using Time‐to‐ON Questionnaire. |
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| Authors: | Stocchi, F., Coletti, C., Bonassi, S., Radicati, F. G., Vacca, L. |
| Source: | European Journal of Neurology. May2019, Vol. 26 Issue 5, p821-826. 6p. 3 Charts, 1 Graph. |
| Subjects: | Parkinson's disease, Dyskinesias |
| Abstract: | Background and purpose: In patients with Parkinson's disease (PD) with motor fluctuations, total daily OFF time is comprised of both end‐of‐dose time and the time taken to turn ON with medication. However, little is known about the impact of delays in ON time. Methods: This was a single‐visit pilot study of fluctuating patients with PD attending a routine appointment. During a single visit, adult patients with idiopathic PD who were treated with levodopa for at least 1 year completed a questionnaire evaluating the time waiting for ON and the symptoms experienced while waiting to turn ON. Patients then completed a 5‐day home time‐to‐ON diary, where they documented how long it took to turn ON following their first morning dose of levodopa in 5‐min increments. Results: A total of 151 consecutive patients completed the study survey, of whom 97 (64.2%) experienced motor fluctuations. Of the patients experiencing motor fluctuations, 54 (56%) reported delays in ON time (latency >30 min) following their first morning dose of levodopa. Half (51%) reported that they had experienced delayed ON at least once in the previous week and 21% reported having delayed ON during all seven mornings of the previous week. In addition, 10% of patients reported having dose failures on four or more mornings during the previous week. The most common symptoms experienced while waiting for ON were slowness (94.8%), fatigue (87.6%), reduced dexterity (82.5%), problems in walking (66.0%) and problems with balance (59.8%). Conclusion: Early‐morning OFF problems such as delays in time to ON and dose failures are common in levodopa‐treated patients with PD. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 135876704 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Early‐morning OFF and levodopa dose failures in patients with Parkinson's disease attending a routine clinical appointment using Time‐to‐ON Questionnaire. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Stocchi%2C+F%2E%22">Stocchi, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Coletti%2C+C%2E%22">Coletti, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Bonassi%2C+S%2E%22">Bonassi, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Radicati%2C+F%2E+G%2E%22">Radicati, F. G.</searchLink><br /><searchLink fieldCode="AR" term="%22Vacca%2C+L%2E%22">Vacca, L.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. May2019, Vol. 26 Issue 5, p821-826. 6p. 3 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Dyskinesias%22">Dyskinesias</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose: In patients with Parkinson's disease (PD) with motor fluctuations, total daily OFF time is comprised of both end‐of‐dose time and the time taken to turn ON with medication. However, little is known about the impact of delays in ON time. Methods: This was a single‐visit pilot study of fluctuating patients with PD attending a routine appointment. During a single visit, adult patients with idiopathic PD who were treated with levodopa for at least 1 year completed a questionnaire evaluating the time waiting for ON and the symptoms experienced while waiting to turn ON. Patients then completed a 5‐day home time‐to‐ON diary, where they documented how long it took to turn ON following their first morning dose of levodopa in 5‐min increments. Results: A total of 151 consecutive patients completed the study survey, of whom 97 (64.2%) experienced motor fluctuations. Of the patients experiencing motor fluctuations, 54 (56%) reported delays in ON time (latency >30 min) following their first morning dose of levodopa. Half (51%) reported that they had experienced delayed ON at least once in the previous week and 21% reported having delayed ON during all seven mornings of the previous week. In addition, 10% of patients reported having dose failures on four or more mornings during the previous week. The most common symptoms experienced while waiting for ON were slowness (94.8%), fatigue (87.6%), reduced dexterity (82.5%), problems in walking (66.0%) and problems with balance (59.8%). Conclusion: Early‐morning OFF problems such as delays in time to ON and dose failures are common in levodopa‐treated patients with PD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.13895 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 821 Subjects: – SubjectFull: Parkinson's disease Type: general – SubjectFull: Dyskinesias Type: general Titles: – TitleFull: Early‐morning OFF and levodopa dose failures in patients with Parkinson's disease attending a routine clinical appointment using Time‐to‐ON Questionnaire. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Stocchi, F. – PersonEntity: Name: NameFull: Coletti, C. – PersonEntity: Name: NameFull: Bonassi, S. – PersonEntity: Name: NameFull: Radicati, F. G. – PersonEntity: Name: NameFull: Vacca, L. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 26 – Type: issue Value: 5 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
