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Homocysteine might increase the risk of recurrence in patients presenting with primary cerebral infarction.

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Title: Homocysteine might increase the risk of recurrence in patients presenting with primary cerebral infarction.
Authors: Anniwaer, Jianati, Liu, Meng-zhuang, Xue, Ke-dong, Maimaiti, Abuduzhayier, Xiamixiding, Aersilan
Source: International Journal of Neuroscience. Jul2019, Vol. 129 Issue 7, p654-659. 6p.
Subjects: Cerebral infarction, Proportional hazards models, Homocysteine, Hypertension
Abstract: Purpose: Although hyperhomocysteinemia (Hhcy) is a risk factor for cerebral infarction, its effect on recurrent cerebral infarction is less-defined. We aimed to investigate the association of Hhcy and increased risk of recurrent cerebral infarct. Materials and methods: From 2011 to 2013, we recruited 231 primary cerebral infarct patients that were divided to a Hhcy group (n = 105) and a control group (n = 126) according to plasma homocysteinemia (Hcy) levels exceeding 15 μmol/L. In this prospective study, risk factors such as gender, age, blood lipid and glucose levels, history of diabetes, high blood pressure, smoking habits and plasma Hhcy levels were determined. A three-year follow-up compared differences in cerebral infarction recurrence rates. Statistical analyses identified whether plasma Hhcy levels were an independent risk factor for recurrent cerebral infarction. Results: Triglyceride and low-density lipoprotein (LDL) levels in the Hhcy group were significantly higher than controls, and cerebral infarct recurrence rates in the Hhcy group exceeded control subject rates through the three-year follow-up (p =.021, p =.036 and p =.025). Cox proportional hazards modeling showed that elevated Hhcy levels (hazard ratio [HR] = 3.062, p <.001), increased age (HR = 1.069, p <.01), circulating triglyceride levels (HR = 1.686, p =.048), and relative National Institutes of Health Stroke (NIHSS) score (HR = 1.068, p =.016) were risk factors for recurrent cerebral infarction. Conclusions: Level of Hhcy was a risk factor for recurrent cerebral infarction. Further, particular demographic and clinical outcomes including age, relative NIHSS scores, and circulating triglyceride levels were markedly associated with the occurrence of cerebral infarction. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Homocysteine might increase the risk of recurrence in patients presenting with primary cerebral infarction.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Neuroscience%22&quot;&gt;International Journal of Neuroscience&lt;/searchLink&gt;. Jul2019, Vol. 129 Issue 7, p654-659. 6p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cerebral+infarction%22&quot;&gt;Cerebral infarction&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Proportional+hazards+models%22&quot;&gt;Proportional hazards models&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Homocysteine%22&quot;&gt;Homocysteine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hypertension%22&quot;&gt;Hypertension&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Although hyperhomocysteinemia (Hhcy) is a risk factor for cerebral infarction, its effect on recurrent cerebral infarction is less-defined. We aimed to investigate the association of Hhcy and increased risk of recurrent cerebral infarct. Materials and methods: From 2011 to 2013, we recruited 231 primary cerebral infarct patients that were divided to a Hhcy group (n = 105) and a control group (n = 126) according to plasma homocysteinemia (Hcy) levels exceeding 15 μmol/L. In this prospective study, risk factors such as gender, age, blood lipid and glucose levels, history of diabetes, high blood pressure, smoking habits and plasma Hhcy levels were determined. A three-year follow-up compared differences in cerebral infarction recurrence rates. Statistical analyses identified whether plasma Hhcy levels were an independent risk factor for recurrent cerebral infarction. Results: Triglyceride and low-density lipoprotein (LDL) levels in the Hhcy group were significantly higher than controls, and cerebral infarct recurrence rates in the Hhcy group exceeded control subject rates through the three-year follow-up (p =.021, p =.036 and p =.025). Cox proportional hazards modeling showed that elevated Hhcy levels (hazard ratio [HR] = 3.062, p &lt;.001), increased age (HR = 1.069, p &lt;.01), circulating triglyceride levels (HR = 1.686, p =.048), and relative National Institutes of Health Stroke (NIHSS) score (HR = 1.068, p =.016) were risk factors for recurrent cerebral infarction. Conclusions: Level of Hhcy was a risk factor for recurrent cerebral infarction. Further, particular demographic and clinical outcomes including age, relative NIHSS scores, and circulating triglyceride levels were markedly associated with the occurrence of cerebral infarction. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of International Journal of Neuroscience is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/00207454.2018.1517762
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 6
        StartPage: 654
    Subjects:
      – SubjectFull: Cerebral infarction
        Type: general
      – SubjectFull: Proportional hazards models
        Type: general
      – SubjectFull: Homocysteine
        Type: general
      – SubjectFull: Hypertension
        Type: general
    Titles:
      – TitleFull: Homocysteine might increase the risk of recurrence in patients presenting with primary cerebral infarction.
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            NameFull: Anniwaer, Jianati
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            NameFull: Liu, Meng-zhuang
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            NameFull: Xue, Ke-dong
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            NameFull: Maimaiti, Abuduzhayier
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            NameFull: Xiamixiding, Aersilan
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              Text: Jul2019
              Type: published
              Y: 2019
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