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Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.

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Title: Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.
Authors: Pettersson, E., Lichtenstein, P., Song, J., Larsson, H., Sullivan, P. F., Bulik, C. M., Davis, L. K., Edenberg, H. J., Gelernter, J., Pardiñas, A. F., Walters, J. T. R., Stahl, E., Polderman, T. J. C., Posthuma, D., Agrawal, A., Børglum, A. D., Demontis, D., Grove, J., Walters, R., Daly, M. J.
Source: Psychological Medicine. May2019, Vol. 49 Issue 7, p1166-1173. 8p.
Subjects: Mental illness genetics, Alcoholism, Anorexia nervosa, Attention-deficit hyperactivity disorder, Autism, Siblings, Mental depression, Genetic disorders, Genetics, Bipolar disorder, Obsessive-compulsive disorder, Schizophrenia, Genotypes
Geographic Terms: Sweden
Abstract: Background: Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders. Methods: We assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia. Results: Heritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50. Conclusions: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.
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  Data: <searchLink fieldCode="AR" term="%22Pettersson%2C+E%2E%22">Pettersson, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lichtenstein%2C+P%2E%22">Lichtenstein, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+J%2E%22">Song, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Larsson%2C+H%2E%22">Larsson, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Sullivan%2C+P%2E+F%2E%22">Sullivan, P. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Bulik%2C+C%2E+M%2E%22">Bulik, C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+L%2E+K%2E%22">Davis, L. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Edenberg%2C+H%2E+J%2E%22">Edenberg, H. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Gelernter%2C+J%2E%22">Gelernter, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Pardiñas%2C+A%2E+F%2E%22">Pardiñas, A. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Walters%2C+J%2E+T%2E+R%2E%22">Walters, J. T. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Stahl%2C+E%2E%22">Stahl, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Polderman%2C+T%2E+J%2E+C%2E%22">Polderman, T. J. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Posthuma%2C+D%2E%22">Posthuma, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Agrawal%2C+A%2E%22">Agrawal, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Børglum%2C+A%2E+D%2E%22">Børglum, A. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Demontis%2C+D%2E%22">Demontis, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Grove%2C+J%2E%22">Grove, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Walters%2C+R%2E%22">Walters, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Daly%2C+M%2E+J%2E%22">Daly, M. J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. May2019, Vol. 49 Issue 7, p1166-1173. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Mental+illness+genetics%22">Mental illness genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholism%22">Alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Siblings%22">Siblings</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Sweden%22">Sweden</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders. Methods: We assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia. Results: Heritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50. Conclusions: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/S0033291718002039
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        Text: English
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