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Bacterial biofilm in adenoids of children with chronic otitis media. Part I: a case control study of prevalence of biofilms in adenoids, risk factors and middle ear biofilms.

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Title: Bacterial biofilm in adenoids of children with chronic otitis media. Part I: a case control study of prevalence of biofilms in adenoids, risk factors and middle ear biofilms.
Authors: Kania, Romain (AUTHOR), Vironneau, Pierre (AUTHOR), Dang, Huong (AUTHOR), Bercot, Béatrice (AUTHOR), Cambau, Emmanuelle (AUTHOR), Verillaud, Benjamin (AUTHOR), Camous, Domitille (AUTHOR), Lamers, Gerda (AUTHOR), Herman, Philippe (AUTHOR), Vicaut, Eric (AUTHOR), Tessier, Natacha (AUTHOR), Van Den Abbeele, Thierry (AUTHOR)
Source: Acta Oto-Laryngologica. Apr2019, Vol. 139 Issue 4, p345-350. 6p.
Subjects: Otitis media diagnosis, Otitis media with effusion, Adenoidectomy, Adenoids, Antibiotics, Biofilms, Biopsy, Chronic diseases, Hypertrophy, Longitudinal method, Middle ear, Scanning electron microscopy, Middle ear ventilation, Disease prevalence, Case-control method, Children, Diagnosis, Disease risk factors
Abstract (English): Background: Biofilms are communities of bacteria embedded in a self-produced glycocalyx matrix. Adenoids have been shown to harbor bacterial biofilms. Aim/objectives: To compare the prevalence of biofilms in adenoid of children with chronic otitis media (COM) (group1) versus a control group without any COM (group 2) having adenoids removed because of hypertrophy. Material and methods: One hundred and three children were prospectively enrolled in this case-control study, group 1 (n = 52) and group 2 (n = 51). The main outcome measurement was the prevalence of biofilm in adenoidectomy specimens analyzed using confocal laser scanning microscopy. Children in group 1 who had middle ear (ME) effusion and requiring the insertion of a tympanostomy tube underwent biopsy of the ME mucosa and effusion sampling. Results: Biofilms were found in adenoids' specimens of both groups and in the ME biopsy and effusion. The biofilm prevalence in adenoids was 63.5% (33/52) in group 1 and 47.1% (24/51) in group 2. Day nursery and previous antibiotics intake were significantly more frequent in group 1 than in group 2. Conclusions and significance: This case-control study demonstrates that adenoid tissue in children with COM contains more mucosal biofilms than adenoid tissue removed for hypertrophy. Biofilm was seen in ME biopsies and effusion. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 背景：生物膜是自产糖萼基质中的细菌群落。腺样体显示含有细菌生物膜。 目的：与因肥大而切除腺样体的对照组（第2组）进行比较, 研究慢性中耳炎（COM）（第1组）儿童腺样体中生物膜的发生率, 。 材料和方法：本病例对照研究前瞻性地招募了103名儿童, 分为第一组（n = 52）和第二组（n = 51）。主要观察指标是用共聚焦激光扫描显微镜分析腺样体切除术标本中生物膜的发生率。第1组中, 有中耳积液需要插入鼓室导管的儿童接受了鼓室粘膜活检和积液取样。 结果：两组的腺样体标本及ME活检和积液中均发现生物膜。第一组中腺样体生物膜的发生率为63.5%（33/52）, 第二组为47.1%（24/51）。日间托儿和以前的抗生素摄入量在第一组中明显高于第2组。 结论与意义：本项病例对照研究表明, COM患儿的腺样体组织中含有的粘膜生物膜多于因肥大而切除的腺样体组织。在ME活检和积液中发现生物膜。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Bacterial biofilm in adenoids of children with chronic otitis media. Part I: a case control study of prevalence of biofilms in adenoids, risk factors and middle ear biofilms.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Kania%2C+Romain%22">Kania, Romain</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vironneau%2C+Pierre%22">Vironneau, Pierre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dang%2C+Huong%22">Dang, Huong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bercot%2C+Béatrice%22">Bercot, Béatrice</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cambau%2C+Emmanuelle%22">Cambau, Emmanuelle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verillaud%2C+Benjamin%22">Verillaud, Benjamin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Camous%2C+Domitille%22">Camous, Domitille</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lamers%2C+Gerda%22">Lamers, Gerda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Herman%2C+Philippe%22">Herman, Philippe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vicaut%2C+Eric%22">Vicaut, Eric</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tessier%2C+Natacha%22">Tessier, Natacha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Den+Abbeele%2C+Thierry%22">Van Den Abbeele, Thierry</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Apr2019, Vol. 139 Issue 4, p345-350. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Otitis+media+diagnosis%22">Otitis media diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Otitis+media+with+effusion%22">Otitis media with effusion</searchLink><br /><searchLink fieldCode="DE" term="%22Adenoidectomy%22">Adenoidectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Adenoids%22">Adenoids</searchLink><br /><searchLink fieldCode="DE" term="%22Antibiotics%22">Antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Biofilms%22">Biofilms</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertrophy%22">Hypertrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+ear%22">Middle ear</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+ear+ventilation%22">Middle ear ventilation</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Biofilms are communities of bacteria embedded in a self-produced glycocalyx matrix. Adenoids have been shown to harbor bacterial biofilms. Aim/objectives: To compare the prevalence of biofilms in adenoid of children with chronic otitis media (COM) (group1) versus a control group without any COM (group 2) having adenoids removed because of hypertrophy. Material and methods: One hundred and three children were prospectively enrolled in this case-control study, group 1 (n = 52) and group 2 (n = 51). The main outcome measurement was the prevalence of biofilm in adenoidectomy specimens analyzed using confocal laser scanning microscopy. Children in group 1 who had middle ear (ME) effusion and requiring the insertion of a tympanostomy tube underwent biopsy of the ME mucosa and effusion sampling. Results: Biofilms were found in adenoids' specimens of both groups and in the ME biopsy and effusion. The biofilm prevalence in adenoids was 63.5% (33/52) in group 1 and 47.1% (24/51) in group 2. Day nursery and previous antibiotics intake were significantly more frequent in group 1 than in group 2. Conclusions and significance: This case-control study demonstrates that adenoid tissue in children with COM contains more mucosal biofilms than adenoid tissue removed for hypertrophy. Biofilm was seen in ME biopsies and effusion. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 背景：生物膜是自产糖萼基质中的细菌群落。腺样体显示含有细菌生物膜。 目的：与因肥大而切除腺样体的对照组（第2组）进行比较, 研究慢性中耳炎（COM）（第1组）儿童腺样体中生物膜的发生率, 。 材料和方法：本病例对照研究前瞻性地招募了103名儿童, 分为第一组（n = 52）和第二组（n = 51）。主要观察指标是用共聚焦激光扫描显微镜分析腺样体切除术标本中生物膜的发生率。第1组中, 有中耳积液需要插入鼓室导管的儿童接受了鼓室粘膜活检和积液取样。 结果：两组的腺样体标本及ME活检和积液中均发现生物膜。第一组中腺样体生物膜的发生率为63.5%（33/52）, 第二组为47.1%（24/51）。日间托儿和以前的抗生素摄入量在第一组中明显高于第2组。 结论与意义：本项病例对照研究表明, COM患儿的腺样体组织中含有的粘膜生物膜多于因肥大而切除的腺样体组织。在ME活检和积液中发现生物膜。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2019.1571282
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Otitis media diagnosis
        Type: general
      – SubjectFull: Otitis media with effusion
        Type: general
      – SubjectFull: Adenoidectomy
        Type: general
      – SubjectFull: Adenoids
        Type: general
      – SubjectFull: Antibiotics
        Type: general
      – SubjectFull: Biofilms
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      – SubjectFull: Biopsy
        Type: general
      – SubjectFull: Chronic diseases
        Type: general
      – SubjectFull: Hypertrophy
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Middle ear
        Type: general
      – SubjectFull: Scanning electron microscopy
        Type: general
      – SubjectFull: Middle ear ventilation
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      – SubjectFull: Disease prevalence
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      – SubjectFull: Case-control method
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      – SubjectFull: Children
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      – SubjectFull: Disease risk factors
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