View in EDS

Aging, cognition, and the brain: effects of age-related variation in white matter integrity on neuropsychological function.

Saved in:
Bibliographic Details
Title: Aging, cognition, and the brain: effects of age-related variation in white matter integrity on neuropsychological function.
Authors: Fan, Yang-Teng, Fang, Ya-Wen, Chen, Ya-Ping, Leshikar, Eric D., Lin, Ching-Po, Tzeng, Ovid J.L., Huang, Hsu-Wen, Huang, Chih-Mao
Source: Aging & Mental Health. Jul2019, Vol. 23 Issue 7, p831-839. 9p. 1 Color Photograph, 2 Charts, 2 Graphs.
Subjects: Brain anatomy, Aging, Diagnosis of brain abnormalities, Cerebral hemispheres, Cognitive testing, Diencephalon, Frontal lobe, Magnetic resonance imaging, Neuropsychological tests, Psychological vulnerability, White matter (Nerve tissue)
Abstract: Alterations in brain structure are viewed as neurobiological indicators which are closely tied to cognitive changes in healthy human aging. The current study used diffusion tensor imaging (DTI) tractography to investigate the relationship between age, brain variation in white matter (WM) integrity, and cognitive function. Sixteen younger adults (aged 20–28 years) and 18 healthy older adults (aged 60–75 years) underwent DTI scanning and a standardized battery of neuropsychological measures. Behaviorally, older adults exhibited poorer performance on multiple cognitive measures compared to younger adults. At the neural level, the effects of aging on theWM integrity were evident within interhemispheric (the anterior portion of corpus callosum) and transverse (the right uncinate fasciculus) fibers of the frontal regions, and the cingulum-angular fibers. Our correlation results showed that age-related WM differentially influenced cognitive function, with increased fractional anisotropy values in both the anterior corpus callosum and the right cingulum/angular fibers positively correlated with performance on the visuospatial task in older adults. Moreover, mediation analysis further revealed that the WM tract integrity of the frontal interhemspheric fibers was a significant mediator of age–visuospatial performance relation in older adults, but not in younger adults. These findings support the vulnerability of the frontal WM fibers to normal aging and push forward our understanding of cognitive aging by providing a more integrative view of the neural basis of linkages among aging, cognition, and brain. [ABSTRACT FROM AUTHOR]
Copyright of Aging & Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 136414778
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Aging, cognition, and the brain: effects of age-related variation in white matter integrity on neuropsychological function.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Fan%2C+Yang-Teng%22">Fan, Yang-Teng</searchLink><br /><searchLink fieldCode="AR" term="%22Fang%2C+Ya-Wen%22">Fang, Ya-Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Ya-Ping%22">Chen, Ya-Ping</searchLink><br /><searchLink fieldCode="AR" term="%22Leshikar%2C+Eric+D%2E%22">Leshikar, Eric D.</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Ching-Po%22">Lin, Ching-Po</searchLink><br /><searchLink fieldCode="AR" term="%22Tzeng%2C+Ovid+J%2EL%2E%22">Tzeng, Ovid J.L.</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Hsu-Wen%22">Huang, Hsu-Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Chih-Mao%22">Huang, Chih-Mao</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Aging+%26+Mental+Health%22">Aging & Mental Health</searchLink>. Jul2019, Vol. 23 Issue 7, p831-839. 9p. 1 Color Photograph, 2 Charts, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis+of+brain+abnormalities%22">Diagnosis of brain abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+hemispheres%22">Cerebral hemispheres</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+testing%22">Cognitive testing</searchLink><br /><searchLink fieldCode="DE" term="%22Diencephalon%22">Diencephalon</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+vulnerability%22">Psychological vulnerability</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Alterations in brain structure are viewed as neurobiological indicators which are closely tied to cognitive changes in healthy human aging. The current study used diffusion tensor imaging (DTI) tractography to investigate the relationship between age, brain variation in white matter (WM) integrity, and cognitive function. Sixteen younger adults (aged 20–28 years) and 18 healthy older adults (aged 60–75 years) underwent DTI scanning and a standardized battery of neuropsychological measures. Behaviorally, older adults exhibited poorer performance on multiple cognitive measures compared to younger adults. At the neural level, the effects of aging on theWM integrity were evident within interhemispheric (the anterior portion of corpus callosum) and transverse (the right uncinate fasciculus) fibers of the frontal regions, and the cingulum-angular fibers. Our correlation results showed that age-related WM differentially influenced cognitive function, with increased fractional anisotropy values in both the anterior corpus callosum and the right cingulum/angular fibers positively correlated with performance on the visuospatial task in older adults. Moreover, mediation analysis further revealed that the WM tract integrity of the frontal interhemspheric fibers was a significant mediator of age–visuospatial performance relation in older adults, but not in younger adults. These findings support the vulnerability of the frontal WM fibers to normal aging and push forward our understanding of cognitive aging by providing a more integrative view of the neural basis of linkages among aging, cognition, and brain. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Aging & Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=136414778
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/13607863.2018.1455804
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 831
    Subjects:
      – SubjectFull: Brain anatomy
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Diagnosis of brain abnormalities
        Type: general
      – SubjectFull: Cerebral hemispheres
        Type: general
      – SubjectFull: Cognitive testing
        Type: general
      – SubjectFull: Diencephalon
        Type: general
      – SubjectFull: Frontal lobe
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Neuropsychological tests
        Type: general
      – SubjectFull: Psychological vulnerability
        Type: general
      – SubjectFull: White matter (Nerve tissue)
        Type: general
    Titles:
      – TitleFull: Aging, cognition, and the brain: effects of age-related variation in white matter integrity on neuropsychological function.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fan, Yang-Teng
      – PersonEntity:
          Name:
            NameFull: Fang, Ya-Wen
      – PersonEntity:
          Name:
            NameFull: Chen, Ya-Ping
      – PersonEntity:
          Name:
            NameFull: Leshikar, Eric D.
      – PersonEntity:
          Name:
            NameFull: Lin, Ching-Po
      – PersonEntity:
          Name:
            NameFull: Tzeng, Ovid J.L.
      – PersonEntity:
          Name:
            NameFull: Huang, Hsu-Wen
      – PersonEntity:
          Name:
            NameFull: Huang, Chih-Mao
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 13607863
          Numbering:
            – Type: volume
              Value: 23
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Aging & Mental Health
              Type: main
ResultId 1