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Larger right inferior frontal gyrus volume and surface area in participants at genetic risk for bipolar disorders.

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Title: Larger right inferior frontal gyrus volume and surface area in participants at genetic risk for bipolar disorders.
Authors: Slaney, C., Garnham, J., Propper, L., Alda, M., Hajek, T., Drobinin, V., Uher, R.
Source: Psychological Medicine. Jun2019, Vol. 49 Issue 8, p1308-1315. 8p.
Subjects: Genetics of bipolar disorder, Biomarkers, Brain mapping, Frontal lobe, Bipolar disorder, Gray matter (Nerve tissue), Mental illness risk factors
Abstract: Background: Larger grey matter volume of the inferior frontal gyrus (IFG) is among the most replicated biomarkers of genetic risk for bipolar disorders (BD). However, the IFG is a heterogeneous prefrontal region, and volumetric findings can be attributable to changes in cortical thickness (CT), surface area (SA) or gyrification. Here, we investigated the morphometry of IFG in participants at genetic risk for BD. Methods: We quantified the IFG cortical grey matter volume in 29 affected, 32 unaffected relatives of BD probands, and 42 controls. We then examined SA, CT, and cortical folding in subregions of the IFG. Results: We found volumetric group differences in the right IFG, with the largest volumes in unaffected high-risk and smallest in control participants (F 2,192 = 3.07, p = 0.01). The volume alterations were localized to the pars triangularis of the IFG (F 2,97 = 4.05, p = 0.02), with no differences in pars opercularis or pars orbitalis. Pars triangularis volume was highly correlated with its SA [Pearson r (101) = 0.88, p < 0.001], which significantly differed between the groups (F 2,97 = 4.45, p = 0.01). As with volume, the mean SA of the pars triangularis was greater in unaffected (corrected p = 0.02) and affected relatives (corrected p = 0.05) compared with controls. We did not find group differences in pars triangularis CT or gyrification. Conclusions: These findings strengthen prior knowledge about the volumetric findings in this region and provide a new insight into the localization and topology of IFG alterations. The unique nature of rIFG morphology in BD, with larger volume and SA early in the course of illness, could have practical implications for detection of participants at risk for BD. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Larger right inferior frontal gyrus volume and surface area in participants at genetic risk for bipolar disorders.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Slaney%2C+C%2E%22&quot;&gt;Slaney, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Garnham%2C+J%2E%22&quot;&gt;Garnham, J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Propper%2C+L%2E%22&quot;&gt;Propper, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alda%2C+M%2E%22&quot;&gt;Alda, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hajek%2C+T%2E%22&quot;&gt;Hajek, T.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Drobinin%2C+V%2E%22&quot;&gt;Drobinin, V.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Uher%2C+R%2E%22&quot;&gt;Uher, R.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychological+Medicine%22&quot;&gt;Psychological Medicine&lt;/searchLink&gt;. Jun2019, Vol. 49 Issue 8, p1308-1315. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetics+of+bipolar+disorder%22&quot;&gt;Genetics of bipolar disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biomarkers%22&quot;&gt;Biomarkers&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Brain+mapping%22&quot;&gt;Brain mapping&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Frontal+lobe%22&quot;&gt;Frontal lobe&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bipolar+disorder%22&quot;&gt;Bipolar disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gray+matter+%28Nerve+tissue%29%22&quot;&gt;Gray matter (Nerve tissue)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+illness+risk+factors%22&quot;&gt;Mental illness risk factors&lt;/searchLink&gt;
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  Data: Background: Larger grey matter volume of the inferior frontal gyrus (IFG) is among the most replicated biomarkers of genetic risk for bipolar disorders (BD). However, the IFG is a heterogeneous prefrontal region, and volumetric findings can be attributable to changes in cortical thickness (CT), surface area (SA) or gyrification. Here, we investigated the morphometry of IFG in participants at genetic risk for BD. Methods: We quantified the IFG cortical grey matter volume in 29 affected, 32 unaffected relatives of BD probands, and 42 controls. We then examined SA, CT, and cortical folding in subregions of the IFG. Results: We found volumetric group differences in the right IFG, with the largest volumes in unaffected high-risk and smallest in control participants (F 2,192 = 3.07, p = 0.01). The volume alterations were localized to the pars triangularis of the IFG (F 2,97 = 4.05, p = 0.02), with no differences in pars opercularis or pars orbitalis. Pars triangularis volume was highly correlated with its SA [Pearson r (101) = 0.88, p &lt; 0.001], which significantly differed between the groups (F 2,97 = 4.45, p = 0.01). As with volume, the mean SA of the pars triangularis was greater in unaffected (corrected p = 0.02) and affected relatives (corrected p = 0.05) compared with controls. We did not find group differences in pars triangularis CT or gyrification. Conclusions: These findings strengthen prior knowledge about the volumetric findings in this region and provide a new insight into the localization and topology of IFG alterations. The unique nature of rIFG morphology in BD, with larger volume and SA early in the course of illness, could have practical implications for detection of participants at risk for BD. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1017/S0033291718001903
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      – Code: eng
        Text: English
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        PageCount: 8
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    Subjects:
      – SubjectFull: Genetics of bipolar disorder
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Brain mapping
        Type: general
      – SubjectFull: Frontal lobe
        Type: general
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Gray matter (Nerve tissue)
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      – SubjectFull: Mental illness risk factors
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      – TitleFull: Larger right inferior frontal gyrus volume and surface area in participants at genetic risk for bipolar disorders.
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              Text: Jun2019
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              Y: 2019
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