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Long-term cardiovascular safety of psychostimulants in children with attention deficit hyperactivity disorder.

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Title: Long-term cardiovascular safety of psychostimulants in children with attention deficit hyperactivity disorder.
Authors: Conzelmann, Annette, Müller, Stefan, Jans, Thomas, Trott, Götz-Erik, Keil, Thomas, Gerlach, Manfred, Renner, Tobias J.
Source: International Journal of Psychiatry in Clinical Practice. Jun2019, Vol. 23 Issue 2, p157-159. 3p.
Subjects: Attention-deficit hyperactivity disorder, Blood pressure, Cardiovascular system, Heart beat, Patient safety, Sex distribution, Body mass index, Treatment effectiveness, Central nervous system stimulants, Children
Abstract: Objective: Side effects are a concern during psychostimulant treatment. Unfortunately, many previous studies only investigated short-term effects of psychostimulants in laboratory settings which lack clinical daily routines. Methods: We examined 1042 patient records of patients with attention deficit hyperactivity disorder (ADHD) who were referred to a pediatric-psychiatry practice over 12 years. Data analysis was based on 466 children with ADHD who were newly treated with psychostimulants and who were not in treatment for elevated blood pressure. We analysed blood pressure percentiles, heart rate and BMI percentiles. Results: There was a decrease in systolic and diastolic blood pressure percentiles. Heart rate was not affected. BMI slightly declined in girls. Conclusions: In general psychostimulants were safe. To further elucidate negative effects of psychostimulants, long-term controlled and randomized studies in naturalistic settings are of interest. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Long-term cardiovascular safety of psychostimulants in children with attention deficit hyperactivity disorder.
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  Data: <searchLink fieldCode="AR" term="%22Conzelmann%2C+Annette%22">Conzelmann, Annette</searchLink><br /><searchLink fieldCode="AR" term="%22Müller%2C+Stefan%22">Müller, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Jans%2C+Thomas%22">Jans, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Trott%2C+Götz-Erik%22">Trott, Götz-Erik</searchLink><br /><searchLink fieldCode="AR" term="%22Keil%2C+Thomas%22">Keil, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Gerlach%2C+Manfred%22">Gerlach, Manfred</searchLink><br /><searchLink fieldCode="AR" term="%22Renner%2C+Tobias+J%2E%22">Renner, Tobias J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Psychiatry+in+Clinical+Practice%22">International Journal of Psychiatry in Clinical Practice</searchLink>. Jun2019, Vol. 23 Issue 2, p157-159. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+system%22">Cardiovascular system</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system+stimulants%22">Central nervous system stimulants</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
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  Label: Abstract
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  Data: Objective: Side effects are a concern during psychostimulant treatment. Unfortunately, many previous studies only investigated short-term effects of psychostimulants in laboratory settings which lack clinical daily routines. Methods: We examined 1042 patient records of patients with attention deficit hyperactivity disorder (ADHD) who were referred to a pediatric-psychiatry practice over 12 years. Data analysis was based on 466 children with ADHD who were newly treated with psychostimulants and who were not in treatment for elevated blood pressure. We analysed blood pressure percentiles, heart rate and BMI percentiles. Results: There was a decrease in systolic and diastolic blood pressure percentiles. Heart rate was not affected. BMI slightly declined in girls. Conclusions: In general psychostimulants were safe. To further elucidate negative effects of psychostimulants, long-term controlled and randomized studies in naturalistic settings are of interest. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2019
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