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Rapid molecular evolution of pain insensitivity in multiple African rodents.

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Title: Rapid molecular evolution of pain insensitivity in multiple African rodents.
Authors: Eigenbrod, Ole (AUTHOR), Debus, Karlien Y. (AUTHOR), Reznick, Jane (AUTHOR), Bennett, Nigel C. (AUTHOR), Sánchez-Carranza, Oscar (AUTHOR), Omerbašić, Damir (AUTHOR), Hart, Daniel W. (AUTHOR), Barker, Alison J. (AUTHOR), Zhong, Wei (AUTHOR), Lutermann, Heike (AUTHOR), Katandukila, Jestina V. (AUTHOR), Mgode, Georgies (AUTHOR), Park, Thomas J. (AUTHOR), Lewin, Gary R. (AUTHOR)
Source: Science (pre-March 2025). 5/31/2019, Vol. 364 Issue 6443, p852-859. 8p. 5 Diagrams.
Subjects: Pain tolerance, Molecular evolution, RNA sequencing, Capsaicin, Hydrogen chloride, Isothiocyanates, Rodent evolution
Geographic Terms: Africa
Abstract: Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Nav1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors.These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant.Our study reveals how evolution can be used as a discovery tool to find molecular mechanisms that shut down pain. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Rapid molecular evolution of pain insensitivity in multiple African rodents.
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  Data: <searchLink fieldCode="AR" term="%22Eigenbrod%2C+Ole%22">Eigenbrod, Ole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Debus%2C+Karlien+Y%2E%22">Debus, Karlien Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reznick%2C+Jane%22">Reznick, Jane</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bennett%2C+Nigel+C%2E%22">Bennett, Nigel C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sánchez-Carranza%2C+Oscar%22">Sánchez-Carranza, Oscar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Omerbašić%2C+Damir%22">Omerbašić, Damir</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hart%2C+Daniel+W%2E%22">Hart, Daniel W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barker%2C+Alison+J%2E%22">Barker, Alison J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Wei%22">Zhong, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lutermann%2C+Heike%22">Lutermann, Heike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Katandukila%2C+Jestina+V%2E%22">Katandukila, Jestina V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mgode%2C+Georgies%22">Mgode, Georgies</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Thomas+J%2E%22">Park, Thomas J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewin%2C+Gary+R%2E%22">Lewin, Gary R.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 5/31/2019, Vol. 364 Issue 6443, p852-859. 8p. 5 Diagrams.
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  Data: <searchLink fieldCode="DE" term="%22Pain+tolerance%22">Pain tolerance</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+evolution%22">Molecular evolution</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+sequencing%22">RNA sequencing</searchLink><br /><searchLink fieldCode="DE" term="%22Capsaicin%22">Capsaicin</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen+chloride%22">Hydrogen chloride</searchLink><br /><searchLink fieldCode="DE" term="%22Isothiocyanates%22">Isothiocyanates</searchLink><br /><searchLink fieldCode="DE" term="%22Rodent+evolution%22">Rodent evolution</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Africa%22">Africa</searchLink>
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  Label: Abstract
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  Data: Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Nav1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors.These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant.Our study reveals how evolution can be used as a discovery tool to find molecular mechanisms that shut down pain. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=136815121
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        Value: 10.1126/science.aau0236
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 852
    Subjects:
      – SubjectFull: Pain tolerance
        Type: general
      – SubjectFull: Molecular evolution
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      – SubjectFull: RNA sequencing
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      – SubjectFull: Capsaicin
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      – SubjectFull: Hydrogen chloride
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      – SubjectFull: Isothiocyanates
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      – SubjectFull: Rodent evolution
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      – SubjectFull: Africa
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      – TitleFull: Rapid molecular evolution of pain insensitivity in multiple African rodents.
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              Text: 5/31/2019
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