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Muscle ciliary neurotrophic factor receptor α contributes to motor neuron STAT3 activation following peripheral nerve lesion.

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Title: Muscle ciliary neurotrophic factor receptor α contributes to motor neuron STAT3 activation following peripheral nerve lesion.
Authors: Lee, Nancy (AUTHOR), Spearry, Rachel P. (AUTHOR), Rydyznski, Carolyn E. (AUTHOR), MacLennan, A. John (AUTHOR)
Source: European Journal of Neuroscience. May2019, Vol. 49 Issue 9, p1084-1090. 7p. 1 Diagram, 3 Graphs.
Subjects: Motor neurons, Peripheral nervous system, Nervous system regeneration, Muscles, Ligand binding (Biochemistry)
Abstract: Expression of the ciliary neurotrophic factor (CNTF) receptor essential ligand binding subunit, CNTF receptor α (CNTFRα), is induced in motor neurons and skeletal muscle following peripheral nerve lesion. We previously found muscle CNTFRα promotes motor neuron axon regeneration post‐lesion. Both nerve lesion and CNTF administration activate motor neuron signal transducer and activator of transcription 3 (STAT3), a transcription factor implicated in axon growth, suggesting CNTF receptors may contribute to the lesion‐induced STAT3 activation. However, many receptor types signal through STAT3, and if CNTF receptors contribute, motor neuron receptors seemed most likely to regulate motor neuron STAT3. To determine the role played by muscle CNTFRα, we used in vivo, muscle‐specific CNTFRα depletion in mice and report here that this selectively impairs the second phase, sustained motor neuron STAT3 activation post‐lesion. Thus, muscle CNTFRα makes an essential contribution to motor neuron STAT3 activation during axon regeneration and may thereby promote axon regeneration through such signaling. We also report CNTFRα quantitative PCR suggesting involvement of many denervated muscle types, as well as muscle damaged at the lesion site. The present data add to the evidence suggesting that enhancing muscle CNTFRα expression may promote motor neuron regeneration in trauma and disease. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Muscle ciliary neurotrophic factor receptor α contributes to motor neuron STAT3 activation following peripheral nerve lesion.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Lee%2C+Nancy%22">Lee, Nancy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spearry%2C+Rachel+P%2E%22">Spearry, Rachel P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rydyznski%2C+Carolyn+E%2E%22">Rydyznski, Carolyn E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MacLennan%2C+A%2E+John%22">MacLennan, A. John</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2019, Vol. 49 Issue 9, p1084-1090. 7p. 1 Diagram, 3 Graphs.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Motor+neurons%22">Motor neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+nervous+system%22">Peripheral nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+regeneration%22">Nervous system regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Muscles%22">Muscles</searchLink><br /><searchLink fieldCode="DE" term="%22Ligand+binding+%28Biochemistry%29%22">Ligand binding (Biochemistry)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Expression of the ciliary neurotrophic factor (CNTF) receptor essential ligand binding subunit, CNTF receptor α (CNTFRα), is induced in motor neurons and skeletal muscle following peripheral nerve lesion. We previously found muscle CNTFRα promotes motor neuron axon regeneration post‐lesion. Both nerve lesion and CNTF administration activate motor neuron signal transducer and activator of transcription 3 (STAT3), a transcription factor implicated in axon growth, suggesting CNTF receptors may contribute to the lesion‐induced STAT3 activation. However, many receptor types signal through STAT3, and if CNTF receptors contribute, motor neuron receptors seemed most likely to regulate motor neuron STAT3. To determine the role played by muscle CNTFRα, we used in vivo, muscle‐specific CNTFRα depletion in mice and report here that this selectively impairs the second phase, sustained motor neuron STAT3 activation post‐lesion. Thus, muscle CNTFRα makes an essential contribution to motor neuron STAT3 activation during axon regeneration and may thereby promote axon regeneration through such signaling. We also report CNTFRα quantitative PCR suggesting involvement of many denervated muscle types, as well as muscle damaged at the lesion site. The present data add to the evidence suggesting that enhancing muscle CNTFRα expression may promote motor neuron regeneration in trauma and disease. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.14304
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 1084
    Subjects:
      – SubjectFull: Motor neurons
        Type: general
      – SubjectFull: Peripheral nervous system
        Type: general
      – SubjectFull: Nervous system regeneration
        Type: general
      – SubjectFull: Muscles
        Type: general
      – SubjectFull: Ligand binding (Biochemistry)
        Type: general
    Titles:
      – TitleFull: Muscle ciliary neurotrophic factor receptor α contributes to motor neuron STAT3 activation following peripheral nerve lesion.
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            NameFull: Lee, Nancy
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            NameFull: Spearry, Rachel P.
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            NameFull: Rydyznski, Carolyn E.
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            NameFull: MacLennan, A. John
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            – D: 01
              M: 05
              Text: May2019
              Type: published
              Y: 2019
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              Value: 49
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