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Impaired cocaine‐induced behavioral plasticity in the male offspring of cocaine‐experienced sires.

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Title: Impaired cocaine‐induced behavioral plasticity in the male offspring of cocaine‐experienced sires.
Authors: Wimmer, Mathieu E. (AUTHOR), Vassoler, Fair M. (AUTHOR), White, Samantha L. (AUTHOR), Schmidt, Heath D. (AUTHOR), Sidoli, Simone (AUTHOR), Han, Yumiao (AUTHOR), Garcia, Benjamin A. (AUTHOR), Pierce, R. Christopher (AUTHOR)
Source: European Journal of Neuroscience. May2019, Vol. 49 Issue 9, p1115-1126. 12p. 1 Chart, 5 Graphs.
Subjects: Drug-seeking behavior, Post-translational modification, Nucleus accumbens, Neuroplasticity, Gene expression, Human behavior models
Abstract: Our previous work indicated that male, but not female, offspring of cocaine‐experienced sires display blunted cocaine self‐administration. We extended this line of investigation to examine behavioral sensitization, a commonly used model of cocaine‐induced behavioral and neuronal plasticity. Results indicated that male, but not female, offspring of cocaine‐taking sires showed deficits in the ability of repeated systemic cocaine injections to induce augmented locomotor activity. The reduced cocaine sensitization phenotype in male progeny was associated with changes in histone post‐translational modifications, epigenetic processes that regulate gene expression by controlling the accessibility of genes to transcriptional machinery, in the nucleus accumbens of first‐generation male progeny. Thus, five histone post‐translational modifications were significantly altered in the male progeny of cocaine‐exposed sires. In contrast, self‐administration of nicotine was unaltered in male and female offspring suggesting that the intergenerational effects of paternal cocaine taking may be drug‐specific. Interestingly, the reduced sensitivity to cocaine previously observed in the male offspring of cocaine‐taking sires dissipated in the grand‐offspring. Both male and female grand‐progeny of cocaine‐exposed sires showed unaltered cocaine‐induced behavioral sensitization and cocaine self‐administration. Taken together, these findings indicate that paternal cocaine taking produces changes in multiple cocaine addiction‐related behaviors in male progeny, which do not persist beyond the first generation of offspring. Moreover, the altered sensitivity to cocaine in first‐generation male progeny of cocaine‐sired male offspring was associated with epigenetic modifications in the nucleus accumbens, a nucleus that plays a critical role in cocaine‐associated behavioral plasticity. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Impaired cocaine‐induced behavioral plasticity in the male offspring of cocaine‐experienced sires.
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  Data: <searchLink fieldCode="AR" term="%22Wimmer%2C+Mathieu+E%2E%22">Wimmer, Mathieu E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vassoler%2C+Fair+M%2E%22">Vassoler, Fair M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22White%2C+Samantha+L%2E%22">White, Samantha L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmidt%2C+Heath+D%2E%22">Schmidt, Heath D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sidoli%2C+Simone%22">Sidoli, Simone</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Yumiao%22">Han, Yumiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garcia%2C+Benjamin+A%2E%22">Garcia, Benjamin A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pierce%2C+R%2E+Christopher%22">Pierce, R. Christopher</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2019, Vol. 49 Issue 9, p1115-1126. 12p. 1 Chart, 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Drug-seeking+behavior%22">Drug-seeking behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Post-translational+modification%22">Post-translational modification</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleus+accumbens%22">Nucleus accumbens</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Human+behavior+models%22">Human behavior models</searchLink>
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  Data: Our previous work indicated that male, but not female, offspring of cocaine‐experienced sires display blunted cocaine self‐administration. We extended this line of investigation to examine behavioral sensitization, a commonly used model of cocaine‐induced behavioral and neuronal plasticity. Results indicated that male, but not female, offspring of cocaine‐taking sires showed deficits in the ability of repeated systemic cocaine injections to induce augmented locomotor activity. The reduced cocaine sensitization phenotype in male progeny was associated with changes in histone post‐translational modifications, epigenetic processes that regulate gene expression by controlling the accessibility of genes to transcriptional machinery, in the nucleus accumbens of first‐generation male progeny. Thus, five histone post‐translational modifications were significantly altered in the male progeny of cocaine‐exposed sires. In contrast, self‐administration of nicotine was unaltered in male and female offspring suggesting that the intergenerational effects of paternal cocaine taking may be drug‐specific. Interestingly, the reduced sensitivity to cocaine previously observed in the male offspring of cocaine‐taking sires dissipated in the grand‐offspring. Both male and female grand‐progeny of cocaine‐exposed sires showed unaltered cocaine‐induced behavioral sensitization and cocaine self‐administration. Taken together, these findings indicate that paternal cocaine taking produces changes in multiple cocaine addiction‐related behaviors in male progeny, which do not persist beyond the first generation of offspring. Moreover, the altered sensitivity to cocaine in first‐generation male progeny of cocaine‐sired male offspring was associated with epigenetic modifications in the nucleus accumbens, a nucleus that plays a critical role in cocaine‐associated behavioral plasticity. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Type: general
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              Text: May2019
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