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Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.

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Title: Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.
Authors: Levi, S (AUTHOR), Goodlad, R A (AUTHOR), Lee, C Y (AUTHOR), Stamp, G (AUTHOR), Walport, M J (AUTHOR), Wright, N A (AUTHOR), Hodgson, H J (AUTHOR)
Source: Lancet. 10/6/1990, Vol. 336 Issue 8719, p840-843. 4p.
Subjects: Animal experimentation, Cell division, Comparative studies, Gastric mucosa, Gastrointestinal agents, Indomethacin, Research methodology, Medical cooperation, Nonsteroidal anti-inflammatory agents, Peptic ulcer, Rats, Research, Stains & staining (Microscopy), Time, Vasodilators, Wound healing, Evaluation research, Misoprostol, Pharmacodynamics
Abstract: To find out whether non-steroidial anti-inflammatory drugs (NSAIDs) inhibit the proliferation of mucosal cells that normally leads to healing of gastric ulcers a microdissection technique was used to quantify mitosis in gastric glands at the ulcer edge in relation to that in the adjacent mucosa. The regeneration index thus obtained of the ulcer edge was greater in the 9 subjects with gastric ulcers not taking NSAIDs (mean index 3.1 [SEM 0.61]) than that in the 8 patients taking NSAIDs (index 1.49 [0.16]). In rats in which gastric ulcers were produced with a cryoprobe, the ulcers were larger and slower to heal in those receiving indomethacin than in controls; also, immunohistochemical staining indicated significantly fewer mitotic cells in glands adjacent to the ulcer in indomethacin-treated rats (8 mitoses [SEM 3]) than in control animals (25 [5]). The prostaglandin E1 analogue misoprostol reversed the inhibition of healing and substantially restored the proliferative rate in the animals. Inhibition of epithelial cell division normally involved in gastric ulcer healing would contribute to the high prevalence of gastric ulcer during NSAID therapy. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Data: Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.
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  Data: <searchLink fieldCode="AR" term="%22Levi%2C+S%22">Levi, S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goodlad%2C+R+A%22">Goodlad, R A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+C+Y%22">Lee, C Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stamp%2C+G%22">Stamp, G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walport%2C+M+J%22">Walport, M J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wright%2C+N+A%22">Wright, N A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hodgson%2C+H+J%22">Hodgson, H J</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 10/6/1990, Vol. 336 Issue 8719, p840-843. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+division%22">Cell division</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Gastric+mucosa%22">Gastric mucosa</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+agents%22">Gastrointestinal agents</searchLink><br /><searchLink fieldCode="DE" term="%22Indomethacin%22">Indomethacin</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Nonsteroidal+anti-inflammatory+agents%22">Nonsteroidal anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Peptic+ulcer%22">Peptic ulcer</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Stains+%26+staining+%28Microscopy%29%22">Stains & staining (Microscopy)</searchLink><br /><searchLink fieldCode="DE" term="%22Time%22">Time</searchLink><br /><searchLink fieldCode="DE" term="%22Vasodilators%22">Vasodilators</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Misoprostol%22">Misoprostol</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: To find out whether non-steroidial anti-inflammatory drugs (NSAIDs) inhibit the proliferation of mucosal cells that normally leads to healing of gastric ulcers a microdissection technique was used to quantify mitosis in gastric glands at the ulcer edge in relation to that in the adjacent mucosa. The regeneration index thus obtained of the ulcer edge was greater in the 9 subjects with gastric ulcers not taking NSAIDs (mean index 3.1 [SEM 0.61]) than that in the 8 patients taking NSAIDs (index 1.49 [0.16]). In rats in which gastric ulcers were produced with a cryoprobe, the ulcers were larger and slower to heal in those receiving indomethacin than in controls; also, immunohistochemical staining indicated significantly fewer mitotic cells in glands adjacent to the ulcer in indomethacin-treated rats (8 mitoses [SEM 3]) than in control animals (25 [5]). The prostaglandin E1 analogue misoprostol reversed the inhibition of healing and substantially restored the proliferative rate in the animals. Inhibition of epithelial cell division normally involved in gastric ulcer healing would contribute to the high prevalence of gastric ulcer during NSAID therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/0140-6736(90)92341-e
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 840
    Subjects:
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Cell division
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Gastric mucosa
        Type: general
      – SubjectFull: Gastrointestinal agents
        Type: general
      – SubjectFull: Indomethacin
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Nonsteroidal anti-inflammatory agents
        Type: general
      – SubjectFull: Peptic ulcer
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Stains & staining (Microscopy)
        Type: general
      – SubjectFull: Time
        Type: general
      – SubjectFull: Vasodilators
        Type: general
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Misoprostol
        Type: general
      – SubjectFull: Pharmacodynamics
        Type: general
    Titles:
      – TitleFull: Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.
        Type: main
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            NameFull: Levi, S
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            NameFull: Goodlad, R A
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            NameFull: Lee, C Y
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            NameFull: Stamp, G
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            NameFull: Walport, M J
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            NameFull: Wright, N A
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            – D: 06
              M: 10
              Text: 10/6/1990
              Type: published
              Y: 1990
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              Value: 01406736
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              Value: 336
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              Value: 8719
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