Case-control study of serum immunoglobulin-E antibodies reactive with soybean in epidemic asthma.
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| Title: | Case-control study of serum immunoglobulin-E antibodies reactive with soybean in epidemic asthma. |
|---|---|
| Authors: | Sunyer, J (AUTHOR), Antó, J M (AUTHOR), Rodrigo, M J (AUTHOR), Morell, F (AUTHOR) |
| Source: | Lancet. 1/28/1989, Vol. 333 Issue 8632, p179-182. 4p. |
| Subjects: | Immunoglobulin analysis, Asthma, Comparative studies, Dust, Epidemics, Research methodology, Medical cooperation, Medical emergencies, Research, Soybean, Disease relapse, Evaluation research |
| Geographic Terms: | Spain |
| Abstract: | Since 1981, twenty-six asthma outbreaks have been identified in Barcelona, all coinciding with the unloading of soybean in the harbour. Serum from patients with epidemic asthma and individually matched controls with non-epidemic asthma was assayed for immunoglobulin-E (IgE) antibodies against soybean antigens by means of a radioallergosorbent test. In 64 of 86 cases (74.4%) there was a reaction with commercial soybean antigen extracts, compared with only 4 of the 86 controls (4.6%) (odds ratio = 61; lower 95% confidence limit = 8.1). The statistical significance was greater for reactions with extracts of soybean dust taken from Barcelona harbour (odds ratio, unquantifiably high; lower 95% confidence limit = 11.7). No other serological covariate (total serum IgE levels or specific IgE levels against the commonest airborne allergens or legumes) confounded the association between serum anti-soybean IgE antibodies and epidemic asthma. These results support a causal relation between the release of dust during unloading of soybean at the harbour and the occurrence of asthma outbreaks, suggesting an underlying allergic mechanism. [ABSTRACT FROM AUTHOR] |
| Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 136953328 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Case-control study of serum immunoglobulin-E antibodies reactive with soybean in epidemic asthma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sunyer%2C+J%22">Sunyer, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Antó%2C+J+M%22">Antó, J M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigo%2C+M+J%22">Rodrigo, M J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morell%2C+F%22">Morell, F</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 1/28/1989, Vol. 333 Issue 8632, p179-182. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Immunoglobulin+analysis%22">Immunoglobulin analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Dust%22">Dust</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemics%22">Epidemics</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+emergencies%22">Medical emergencies</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Soybean%22">Soybean</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Spain%22">Spain</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Since 1981, twenty-six asthma outbreaks have been identified in Barcelona, all coinciding with the unloading of soybean in the harbour. Serum from patients with epidemic asthma and individually matched controls with non-epidemic asthma was assayed for immunoglobulin-E (IgE) antibodies against soybean antigens by means of a radioallergosorbent test. In 64 of 86 cases (74.4%) there was a reaction with commercial soybean antigen extracts, compared with only 4 of the 86 controls (4.6%) (odds ratio = 61; lower 95% confidence limit = 8.1). The statistical significance was greater for reactions with extracts of soybean dust taken from Barcelona harbour (odds ratio, unquantifiably high; lower 95% confidence limit = 11.7). No other serological covariate (total serum IgE levels or specific IgE levels against the commonest airborne allergens or legumes) confounded the association between serum anti-soybean IgE antibodies and epidemic asthma. These results support a causal relation between the release of dust during unloading of soybean at the harbour and the occurrence of asthma outbreaks, suggesting an underlying allergic mechanism. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=136953328 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/s0140-6736(89)91201-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 179 Subjects: – SubjectFull: Immunoglobulin analysis Type: general – SubjectFull: Asthma Type: general – SubjectFull: Comparative studies Type: general – SubjectFull: Dust Type: general – SubjectFull: Epidemics Type: general – SubjectFull: Research methodology Type: general – SubjectFull: Medical cooperation Type: general – SubjectFull: Medical emergencies Type: general – SubjectFull: Research Type: general – SubjectFull: Soybean Type: general – SubjectFull: Disease relapse Type: general – SubjectFull: Evaluation research Type: general – SubjectFull: Spain Type: general Titles: – TitleFull: Case-control study of serum immunoglobulin-E antibodies reactive with soybean in epidemic asthma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sunyer, J – PersonEntity: Name: NameFull: Antó, J M – PersonEntity: Name: NameFull: Rodrigo, M J – PersonEntity: Name: NameFull: Morell, F IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 01 Text: 1/28/1989 Type: published Y: 1989 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 333 – Type: issue Value: 8632 Titles: – TitleFull: Lancet Type: main |
| ResultId | 1 |
