Features of endothelial dysfunction in early diabetic nephropathy.
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| Title: | Features of endothelial dysfunction in early diabetic nephropathy. |
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| Authors: | Jensen, T (AUTHOR), Bjerre-Knudsen, J (AUTHOR), Feldt-Rasmussen, B (AUTHOR), Deckert, T (AUTHOR) |
| Source: | Lancet. 3/4/1989, Vol. 333 Issue 8637, p461-463. 3p. |
| Abstract: | The release of tissue plasminogen activator (tPA) by vascular endothelial cells during exercise was studied in forty men with insulin-dependent diabetes. Three groups, matched for age and diabetes duration, were defined as: group I (n = 19), normal urinary albumin excretion (less than 30 mg/24 h); group II (n = 11), incipient diabetic nephropathy (30-300 mg albumin excreted per 24 h); and group III (n = 10), clinical diabetic nephropathy (more than 300 mg albumin excreted per 24 h). Nine non-diabetic men served as controls. The rise in tPA antigen with exercise was similar in the controls and group I but significantly smaller in groups II and III (p less than 0.01). The albumin transcapillary escape rate was significantly higher in groups II and III than in group I and normal controls (p less than 0.01). The basal plasma level of von Willebrand factor was higher in groups III (p less than 0.01) and II (difference not significant, p = 0.06) than in group I and normal controls. These findings suggest that insulin-dependent diabetic patients with only slightly raised urinary albumin excretion have general endothelial cell dysfunction or damage. It is not yet clear whether these changes are important in the pathogenesis of thrombosis and atherosclerosis in these patients. [ABSTRACT FROM AUTHOR] |
| Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 136953567 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Features of endothelial dysfunction in early diabetic nephropathy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jensen%2C+T%22">Jensen, T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bjerre-Knudsen%2C+J%22">Bjerre-Knudsen, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feldt-Rasmussen%2C+B%22">Feldt-Rasmussen, B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deckert%2C+T%22">Deckert, T</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/4/1989, Vol. 333 Issue 8637, p461-463. 3p. – Name: Abstract Label: Abstract Group: Ab Data: The release of tissue plasminogen activator (tPA) by vascular endothelial cells during exercise was studied in forty men with insulin-dependent diabetes. Three groups, matched for age and diabetes duration, were defined as: group I (n = 19), normal urinary albumin excretion (less than 30 mg/24 h); group II (n = 11), incipient diabetic nephropathy (30-300 mg albumin excreted per 24 h); and group III (n = 10), clinical diabetic nephropathy (more than 300 mg albumin excreted per 24 h). Nine non-diabetic men served as controls. The rise in tPA antigen with exercise was similar in the controls and group I but significantly smaller in groups II and III (p less than 0.01). The albumin transcapillary escape rate was significantly higher in groups II and III than in group I and normal controls (p less than 0.01). The basal plasma level of von Willebrand factor was higher in groups III (p less than 0.01) and II (difference not significant, p = 0.06) than in group I and normal controls. These findings suggest that insulin-dependent diabetic patients with only slightly raised urinary albumin excretion have general endothelial cell dysfunction or damage. It is not yet clear whether these changes are important in the pathogenesis of thrombosis and atherosclerosis in these patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/s0140-6736(89)91365-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 461 Titles: – TitleFull: Features of endothelial dysfunction in early diabetic nephropathy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jensen, T – PersonEntity: Name: NameFull: Bjerre-Knudsen, J – PersonEntity: Name: NameFull: Feldt-Rasmussen, B – PersonEntity: Name: NameFull: Deckert, T IsPartOfRelationships: – BibEntity: Dates: – D: 04 M: 03 Text: 3/4/1989 Type: published Y: 1989 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 333 – Type: issue Value: 8637 Titles: – TitleFull: Lancet Type: main |
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