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Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients.

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Title: Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients.
Authors: First, M R (AUTHOR), Schroeder, T J (AUTHOR), Weiskittel, P (AUTHOR), Myre, S A (AUTHOR), Alexander, J W (AUTHOR), Pesce, A J (AUTHOR)
Source: Lancet. 11/18/1989, Vol. 334 Issue 8673, p1198-1201. 4p.
Subjects: Combination drug therapy, Comparative studies, Drug interactions, Drug administration, Clinical drug trials, High performance liquid chromatography, Immunosuppression, Ketoconazole, Kidney transplantation, Longitudinal method, Research methodology, Medical cooperation, Oral drug administration, Reoperation, Research, Cost analysis, Evaluation research, Cyclosporins, Therapeutics
Abstract: 18 renal transplant recipients receiving cyclosporin, prednisone, and azathioprine were given ketoconazole, a potent inhibitor of the cytochrome P-450 enzyme system. Within a month ketoconazole-induced blockade of cyclosporin metabolism allowed a significant reduction (451 vs 106 mg/day; 77%) of the mean dose of cyclosporin without altering cyclosporin whole blood trough levels, although maximum blood levels were almost halved. This dose reduction was maintained in patients followed up for up to 13 months. Renal and hepatic function were unchanged after the addition of ketoconazole. This drug interaction has the potential to reduce dramatically expenditure on cyclosporin in transplant recipients. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients.
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  Data: <searchLink fieldCode="AR" term="%22First%2C+M+R%22">First, M R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schroeder%2C+T+J%22">Schroeder, T J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weiskittel%2C+P%22">Weiskittel, P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Myre%2C+S+A%22">Myre, S A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alexander%2C+J+W%22">Alexander, J W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pesce%2C+A+J%22">Pesce, A J</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 11/18/1989, Vol. 334 Issue 8673, p1198-1201. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Combination+drug+therapy%22">Combination drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+interactions%22">Drug interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+administration%22">Drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+drug+trials%22">Clinical drug trials</searchLink><br /><searchLink fieldCode="DE" term="%22High+performance+liquid+chromatography%22">High performance liquid chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Immunosuppression%22">Immunosuppression</searchLink><br /><searchLink fieldCode="DE" term="%22Ketoconazole%22">Ketoconazole</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+transplantation%22">Kidney transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Oral+drug+administration%22">Oral drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Reoperation%22">Reoperation</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+analysis%22">Cost analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclosporins%22">Cyclosporins</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Data: 18 renal transplant recipients receiving cyclosporin, prednisone, and azathioprine were given ketoconazole, a potent inhibitor of the cytochrome P-450 enzyme system. Within a month ketoconazole-induced blockade of cyclosporin metabolism allowed a significant reduction (451 vs 106 mg/day; 77%) of the mean dose of cyclosporin without altering cyclosporin whole blood trough levels, although maximum blood levels were almost halved. This dose reduction was maintained in patients followed up for up to 13 months. Renal and hepatic function were unchanged after the addition of ketoconazole. This drug interaction has the potential to reduce dramatically expenditure on cyclosporin in transplant recipients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/s0140-6736(89)91802-3
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 4
        StartPage: 1198
    Subjects:
      – SubjectFull: Combination drug therapy
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Drug interactions
        Type: general
      – SubjectFull: Drug administration
        Type: general
      – SubjectFull: Clinical drug trials
        Type: general
      – SubjectFull: High performance liquid chromatography
        Type: general
      – SubjectFull: Immunosuppression
        Type: general
      – SubjectFull: Ketoconazole
        Type: general
      – SubjectFull: Kidney transplantation
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Oral drug administration
        Type: general
      – SubjectFull: Reoperation
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Cost analysis
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Cyclosporins
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients.
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            NameFull: Myre, S A
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            NameFull: Alexander, J W
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            NameFull: Pesce, A J
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            – D: 18
              M: 11
              Text: 11/18/1989
              Type: published
              Y: 1989
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              Value: 334
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              Value: 8673
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