Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients.
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| Title: | Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients. |
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| Authors: | First, M R (AUTHOR), Schroeder, T J (AUTHOR), Weiskittel, P (AUTHOR), Myre, S A (AUTHOR), Alexander, J W (AUTHOR), Pesce, A J (AUTHOR) |
| Source: | Lancet. 11/18/1989, Vol. 334 Issue 8673, p1198-1201. 4p. |
| Subjects: | Combination drug therapy, Comparative studies, Drug interactions, Drug administration, Clinical drug trials, High performance liquid chromatography, Immunosuppression, Ketoconazole, Kidney transplantation, Longitudinal method, Research methodology, Medical cooperation, Oral drug administration, Reoperation, Research, Cost analysis, Evaluation research, Cyclosporins, Therapeutics |
| Abstract: | 18 renal transplant recipients receiving cyclosporin, prednisone, and azathioprine were given ketoconazole, a potent inhibitor of the cytochrome P-450 enzyme system. Within a month ketoconazole-induced blockade of cyclosporin metabolism allowed a significant reduction (451 vs 106 mg/day; 77%) of the mean dose of cyclosporin without altering cyclosporin whole blood trough levels, although maximum blood levels were almost halved. This dose reduction was maintained in patients followed up for up to 13 months. Renal and hepatic function were unchanged after the addition of ketoconazole. This drug interaction has the potential to reduce dramatically expenditure on cyclosporin in transplant recipients. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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