Using subjective expectations to model the neural underpinnings of proactive inhibition.
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| Title: | Using subjective expectations to model the neural underpinnings of proactive inhibition. |
|---|---|
| Authors: | Pas, Pascal (AUTHOR), Plessis, Stefan Du (AUTHOR), Munkhof, Hanna E. (AUTHOR), Gladwin, Thomas E. (AUTHOR), Vink, Matthijs (AUTHOR) |
| Source: | European Journal of Neuroscience. Jun2019, Vol. 49 Issue 12, p1575-1586. 12p. 1 Color Photograph, 2 Diagrams, 3 Charts, 1 Graph. |
| Subjects: | Parietal lobe, Brain |
| Abstract: | Proactive inhibition – the anticipation of having to stop a response – relies on objective information contained in cue‐related contingencies in the environment, as well as on the subjective interpretation derived from these cues. To date, most studies of brain areas underlying proactive inhibition have exclusively considered the objective predictive value of environmental cues, by varying the probability of stop‐signals. However, by only taking into account the effect of different cues on brain activation, the subjective component of how cues affect behavior is ignored. We used a modified stop‐signal response task that includes a measurement for subjective expectation, to investigate the effect of this subjective interpretation. After presenting a cue indicating the probability that a stop‐signal will occur, subjects were asked whether they expected a stop‐signal to occur. Furthermore, response time was used to retrospectively model brain activation related to stop‐expectation. We found more activation during the cue period for 50% stop‐signal probability, when contrasting with 0%, in the mid and inferior frontal gyrus, inferior parietal lobe and putamen. When contrasting expected vs. unexpected trials, we found modest effects in the mid frontal gyrus, parietal, and occipital areas. With our third contrast, we modeled brain activation during the cue with trial‐by‐trial variances in response times. This yielded activation in the putamen, inferior parietal lobe, and mid frontal gyrus. Our study is the first to use the behavioral effects of proactive inhibition to identify the underlying brain regions, by employing an unbiased task‐design that temporally separates cue and response. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 137091915 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Using subjective expectations to model the neural underpinnings of proactive inhibition. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pas%2C+Pascal%22">Pas, Pascal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plessis%2C+Stefan+Du%22">Plessis, Stefan Du</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Munkhof%2C+Hanna+E%2E%22">Munkhof, Hanna E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gladwin%2C+Thomas+E%2E%22">Gladwin, Thomas E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vink%2C+Matthijs%22">Vink, Matthijs</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jun2019, Vol. 49 Issue 12, p1575-1586. 12p. 1 Color Photograph, 2 Diagrams, 3 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Parietal+lobe%22">Parietal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Proactive inhibition – the anticipation of having to stop a response – relies on objective information contained in cue‐related contingencies in the environment, as well as on the subjective interpretation derived from these cues. To date, most studies of brain areas underlying proactive inhibition have exclusively considered the objective predictive value of environmental cues, by varying the probability of stop‐signals. However, by only taking into account the effect of different cues on brain activation, the subjective component of how cues affect behavior is ignored. We used a modified stop‐signal response task that includes a measurement for subjective expectation, to investigate the effect of this subjective interpretation. After presenting a cue indicating the probability that a stop‐signal will occur, subjects were asked whether they expected a stop‐signal to occur. Furthermore, response time was used to retrospectively model brain activation related to stop‐expectation. We found more activation during the cue period for 50% stop‐signal probability, when contrasting with 0%, in the mid and inferior frontal gyrus, inferior parietal lobe and putamen. When contrasting expected vs. unexpected trials, we found modest effects in the mid frontal gyrus, parietal, and occipital areas. With our third contrast, we modeled brain activation during the cue with trial‐by‐trial variances in response times. This yielded activation in the putamen, inferior parietal lobe, and mid frontal gyrus. Our study is the first to use the behavioral effects of proactive inhibition to identify the underlying brain regions, by employing an unbiased task‐design that temporally separates cue and response. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=137091915 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.14308 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1575 Subjects: – SubjectFull: Parietal lobe Type: general – SubjectFull: Brain Type: general Titles: – TitleFull: Using subjective expectations to model the neural underpinnings of proactive inhibition. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pas, Pascal – PersonEntity: Name: NameFull: Plessis, Stefan Du – PersonEntity: Name: NameFull: Munkhof, Hanna E. – PersonEntity: Name: NameFull: Gladwin, Thomas E. – PersonEntity: Name: NameFull: Vink, Matthijs IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: Jun2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 49 – Type: issue Value: 12 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
